Evaluation of efficacy and safety of coenzyme Q10 in pediatric hemodialysis patients: a randomized controlled trial by Salma A. Rahman Sharaf, Sarah Farid Fahmy, Heba M. Adel Abou Zaghla, Ahmed Hussein Hassan, Sara Mahmoud Zaki

“…Further research is needed to determine whether coenzyme Q10 treatment improves clinical outcomes such as infection, hospitalization, cardiovascular events, and mortality in pediatric hemodialysis patients. …”
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Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…Prior FMT treatment in the context of ETEC infection indicated a potential protective role, as evidenced by a significant shift in microbial diversity and metabolomic compositions and decreased diarrhea severity even though no effect on pathogen shedding was evident. …”
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RESISTANCE TO THE BLAST AGENT AND THE MORPHOBIOLOGICALFEATURES OF GENOTYPES IN THE Oryza sativa L. COLLECTION FROM VARIOUS ECOLOGICAL AND GEOGRAPHICAL GROUPS IN CONDITIONS OF КUBAN... by T. L. Korotenko, O. A. Bragina, I. I. Suprun, Zh. M. Mukhina, Yu. V. Epifanovich, A. A. Petrukhnenko, T. А. Khorina

“…The results of the comparison of germplasm of domestic and foreign varieties according to the degree of resistance to the pathogen in conditions of natural infection in the field experiment for five years are presented. …”
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Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides by Christina M. Homer, Elena Ochoa, Mark Voorhies, Anita Sil

“…Together, our data reveal multiple strategies to optimize in vitro spherulation growth, enabling characterization of this virulence-relevant morphology.IMPORTANCECoccidioides spp. are thermally dimorphic fungal pathogens found in the Southwest United States, Mexico, Central America, and South America. Coccidioides can infect both immunocompetent and immunocompromised people and can cause a devastating disseminated infection, including meningitis, with 30% mortality despite all currently available treatments. …”
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Within-hospital Temporal Clustering of Postoperative Complications and Implications for Safety Monitoring and Benchmarking Using ACS-NSQIP Data by Mark E. Cohen, PhD, Yaoming Liu, PhD, Clifford Y. Ko, MD, MS, MSHS, FACS, Bruce L. Hall, MD, PhD, MBA, FACS

“…Hospital-specific Cox proportional hazards regression was used to estimate the incidence of mortality, morbidity, and surgical site infection (SSI) over a 30-day postoperative period, with risk adjustment for patient and procedure and with additional adjustments for linear trend, day-of-week, and season. …”
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Incidence and Associated Factors of Laryngospasm among Pediatric Patients Who Underwent Surgery under General Anesthesia, in University of Gondar Compressive Specialized Hospital,... by Wubie Birlie Chekol, Debas Yaregal Melesse

“…In multivariable analysis, airway anomalies (AOR: 14.64, 95% CI: 1.71, 125.04), secretion (AOR: 2.45, 95% CI: 1.19, 5.06), attempts of airway devices (AOR: 2.47, 95% CI: 1.16, 5.22), upper respiratory tract infection (AOR: 2.91, 95% CI: 1.008, 8.41), and inadequate depth of anesthesia (AOR: 7.92, 95% CI: 2.7, 23.22) were significantly associated with incidence of laryngospasm. …”
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Characteristics of virulence of Puccinia triticina populations and the potential of the Lr24, Lr25, LrSp genes for spring common wheat breeding in the Southern Ural by V. A. Tyunin, E. R. Shreyder, E. I. Gultyaeva, E. L. Shaydayuk

“…The aim of this work was analysis of Puccinia triticina populations in the Chelyabinsk region for virulence and studying the effectiveness of Lr-genes at the field for improving and stabilization of genetic protection from wheat leaf rust in the Southern Urals. Infection materials were collected in the experimental field of the Сhelyabinsk Research Institute of Agriculture from breeding lines, commercial and perspective wheat varieties in 2014–2016. …”
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Role of outer membrane vesicles of hypervirulent Klebsiella pneumoniae isolated from bovine uterine discharge in pro-inflammatory dysregulation by A. F. Daham, A. H. Jaber, A. Neamah, H. Al-Karagoly

“…Notably, incubating THP-1 cells with high con-centrations of hvKP OMVs inhibited IL-1β and TNF responses, indicating that these OMVs may not only facilitate the internalisation of the bacterium by THP-1 cells but also suppress the cells’ innate immune response to hvKP infection. This ability of hvKP OMVs to evade the immune system and modulate host responses contributes significantly to the bacterium’s pathogenicity.…”

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…Oral administration of the GZNL-P36 results in significantly improved survival and notable reductions in lung viral loads and lesions in SARS-CoV-2 infection mouse model, consistent with RNA-seq data analysis. …”
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Effectiveness of sacral neuromodulation with 3D-printing and ultrasound localization for treating neurogenic bladder in patients with pelvic structural anomalies by Runze Liu, Yuxuan Zhou, Qiang Hao, Yaoguang Zhang, Peng Zhang, Guoqing Chen, Yong Zhang

“…Metrics compared included the number of punctures, average puncture duration, intraoperative SNS tuning time, effective initial voltage, postoperative testing duration, phase two conversion rates, and the incidence of bleeding and infection. Results: The study group experienced significantly fewer punctures compared to the control group (2.21 ± 0.92 vs 9.29 ± 4.37) (P < 0.01), had a shorter average puncture duration (5.71 ± 2.69 min vs. 28.60 ± 9.69 min) (P < 0.01), and required a lower effective initial voltage (0.87 ± 0.23v vs. 1.38 ± 0.52v) (P < 0.01). …”
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Is <i>Punica granatum</i> Efficient Against Sepsis? A Comparative Study of Amifostine Versus Pomegranate by Kazim Sahin, Sena Sahin Aktura, Ilkay Bahceci, Tolga Mercantepe, Levent Tumkaya, Atilla Topcu, Filiz Mercantepe, Omer Faruk Duran, Huseyin Avni Uydu, Zihni Acar Yazici

“…Sepsis is a clinical condition causing tissue damage as a result of infection and an exaggerated immune response. Sepsis causes 11 million deaths annually, a third of which are associated with acute lung injury (ALI). …”
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Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching by Amit Adlakha, Thomas J. Williams, Xinxin Shou, Anna K. Reed, Boris Lenhard, Darius Armstrong-James

“…Summary: Invasive pulmonary aspergillosis is a lethal opportunistic fungal infection in transplant recipients receiving calcineurin inhibitors. …”
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Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases by Soumaya Touzani, Abderrahim El Bouazzaoui, Fatima Bouyarmane, Kaoutar Faraj, Nawfal Houari, Brahim Boukatta, Nabil Kanjaa

“…Severe acute cholangitis is a life-threatening biliary infection, leading to organ dysfunction, septic shock, and naturally death. …”
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Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans by Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl

“…Furthermore, Perforin-2 was dispensable for antifungal immunity during C. albicans bloodstream infection. These results suggest that Perforin-2 is not essential for host defense against fungal infections in otherwise immune-competent mice.IMPORTANCEHumans encounter fungal pathogens daily and rely on innate immune cells to clear Aspergillus fumigatus, the leading cause of mold pneumonia worldwide, and Candida albicans, the most common cause of fungal bloodstream infections. …”
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ULSOSEAL Technique: A Unique Technique to Achieve Hemostasis Using ExoSeal in High-Risk Patients after Common Femoral Artery Puncture by Yohsuke Honda, Shinsuke Mori, Tomoya Fukagawa, Toshihiko Kishida, Takahide Nakano, Shigemitsu Shirai, Masafumi Mizusawa, Kenji Makino, Masakazu Tsutsumi, Norihiro Kobayashi, Masahiro Yamawaki, Yoshiaki Ito

“…There was no incidence of vessel occlusion, pseudoaneurysm, arteriovenous fistula, infection, and secondary bleeding. One patient developed a hematoma (>5 cm in size); however, it occurred before the use of ExoSeal due to side leakage from the inserted sheath. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…The causal organism is Fasciolopsis buski, a giant intestinal fluke that infects humans and causes diarrhoea, fever, ascites, and intestinal blockage. …”
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Presence of dengue virus RNA in urine and oral fluid of laboratory-confirmed dengue patients: Implications for wastewater surveillance by Christine Stauber, Leile Camila Jacob-Nascimento, Caroline Grosch, Moisés da Silva Sousa, Moyra M. Portilho, Rosângela O. Anjos, Margo A. Brinton, Uriel Kitron, Mitermayer G. Reis, Guilherme S. Ribeiro

“…Patients with RT-qPCR-positive urine had a lower frequency of DENV IgG in acute-phase serum (a proxy for secondary infection) (57 % vs. 74 %) and a lower median serum RT-qPCR cycle threshold than those with negative urine (21.8 vs. 23.9). …”
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Nasal Carriage of Methicillin-Resistant Staphylococcus aureus among Health Care Workers in Tertiary and Regional Hospitals in Dar es Salam, Tanzania by Agricola Joachim, Sabrina J. Moyo, Lillian Nkinda, Mtebe Majigo, Sima Rugarabamu, Elizabeth G. Mkashabani, Elia J. Mmbaga, Naboth Mbembati, Said Aboud, Eligius F. Lyamuya

“…In conclusion, we found a high nasal carriage of MRSA and resistance to commonly prescribed antimicrobial agents among HCWs. Implementation of infection control measures including contact precautions, urgent reporting of MRSA laboratory results, and routine MRSA screening of HCWs is highly needed to reduce MRSA spreading.…”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

“…SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein family in mice, is synthesized primarily as an acute phase reactant in response to infection, inflammation and trauma. An increasing number of evidence suggests that SAA3 exerts a vital role in the fibrotic process, even though the underlying mechanisms are not yet fully comprehended. …”
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Adverse events following immunization surveillance on two types of enterovirus 71 vaccines: A real-world comparative study in China by Yiqing Zhu, Yihan Wang, Jinghui Wang, Yafei Wang, Li Sun, Shiheng Cui, Jing Li, Yu Guo

“…The EV71 vaccine is advisable recommend to the appropriate age children to prevent EV7l infection. Both the EV71-Vero and EV71-H2 vaccines have good safety profiles. …”
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