High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study by Raul D. Bernabe-Dones, Maria Gonzalez-Pons, Alejandro Villar-Prados, Mercedes Lacourt-Ventura, Heriberto Rodríguez-Arroyo, Sharon Fonseca-Williams, Francisco E. Velazquez, Yaritza Diaz-Algorri, Sofia M. Lopez-Diaz, Nayra Rodríguez, Yasuhiro Yamamura, Marcia Cruz-Correa

“…This is the first report showing the high prevalence of HPV infections in Caribbean Hispanic colorectal tumors. …”
Get full text

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

“…Results We identified SAVs at infected wound sites, linking them to delayed healing of wounds. …”
Get full text

Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients by Maria Martinez-Urbistondo, Alberto Mora-Vargas, Esther Expósito-Palomo, Raquel Castejón, M. Jesús Citores, Silvia Rosado, Carmen de Mendoza, Isolina Baños, Ana Fernández-Cruz, Lidia Daimiel, Rodrigo San-Cristóbal, Juan Antonio Vargas, J. Alfredo Martinez

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” …”
Get full text

Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis by Najeeha Talat Iqbal, Hana Khan, Aqsa Khalid, Syed Faisal Mahmood, Nosheen Nasir, Iffat Khanum, Isadora de Siqueira, Wes Van Voorhis

“…Most studies define Long COVID, through symptoms like fatigue, brain fog, joint pain, and headache prevailing four or more weeks post-initial infection. Global variations in Long COVID presentation and symptoms make it challenging to standardize features of Long COVID. …”
Get full text

Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories by Kurayi G. Mahachi, Marie Ozanne, Patrick Bourdeau, Juliana Sarquis, Eric Kontowicz, Laia Solano-Gallego, Luis Cardoso, Gaetano Oliva, Gad Baneth, Maria Grazia Pennisi, Angela M. Toepp, Guadalupe Miró, Margaret Carrel, Christine A. Petersen

“…To assure consistent and accurate surveillance of canine infection and prevent transmission to people, consistent diagnosis of canine L. infantum infection across this region is essential for protecting both human and animal health. …”
Get full text

In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…Compounds such as cinanserin, nelfinavir, baicalin, baicalein, candesartan cilexetil, chloroquine, dipyridamole, and hydroxychloroquine have the ability to prevent SARS-CoV-2 Mpro from facilitating COVID 19 infection; thus, they treat COVID 19. However, these drugs majorly act to reduce the symptoms of the disease. …”
Get full text

Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases by Mohamed Elbadawy, Nagisa Saito, Yuki Kato, Kimika Hayashi, Amira Abugomaa, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Masahiro Kaneda, Hideyuki Yamawaki, Kazuaki Sasaki, Tatsuya Usui, Tsutomu Omatsu

“…The respiratory tract is one of the primary routes of viral infection, and the establishment of bat lung organoids (BLO) is necessary to study the viral susceptibility in bats. …”
Get full text

Characterisation of internal tremors and vibration symptoms by Harlan M Krumholz, Mitsuaki Sawano, Richa Sharma, Tianna Zhou, Dorothy Massey, Anna D Baker, Diana Berrent Güthe, Nick Güthe, Suzanne Pincus Shidlovsky, Liza Fisher, Connor B Grady, Cesar Caraballo

“…Among the responses, many described symptoms that varied in location, timing and triggers, occurred soon after their COVID-19 infection, and were markedly debilitating. There were often frustrating experiences with the healthcare system.Conclusions This study describes key themes and experiences among a group of people reporting long COVID and having a prolonged and debilitating symptom complex that prominently features internal tremors and vibrations.…”
Get full text

Adverse drug events (ADEs) risk signal mining related to eculizumab based on the FARES database by Xi-Feng Wang, Lu-Ri Bao, Ta-La Hu, Rui-Feng Xu, Wu-Niri Gao, Jing-Yuan Wang, Jian-Rong Zhao, Zhen-Li Fu, Shu-Fang Wang, Yan Meng

“…These PTs reported adverse reactions consistent with the specifications, such as fatigue, nasopharyngitis, meningococcal infection, fever, and anemia. Some PTs, such as aplastic anemia, gene mutation, mastication disorder, kidney fibrosis, BK virus infection, abnormal neutrophil count, C3 glomerulopathy, neuroblastoma, and glomerulonephritis membranoproliferative, were also detected outside the instructions. …”
Get full text

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…Furthermore, COVID-19 infection significantly increases the likelihood of developing these sequelae compared to uninfected individuals. …”
Get full text

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice by Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang

“…Here, we assessed the pathogenicity of SARS-CoV-2 (WA1/2020) containing mutations from the Omicron BA.1 variant in K18-hACE2 mice. At an infection dose of 104 plaque-forming units (PFU), WA1 virus carrying Omicron BA.1 Nsp14(I42V), E(T9I), M(D3G/Q19E/A63T), but not Nsp6(Δ105–107, I189V), substitutions showed significant reduction in lethality. …”
Get full text

Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC by Dakshinya M, Anitha P, A.S. Smiline Girija, Paramasivam A, Vijayashree Priyadharsini J

“…Further investigations are warranted to confirm the functional role of these genes in establishing the cancer phenotype in patients with chronic infection with Pg.…”
Get full text

Residual transmission of schistosomiasis in Ndikinimeki Health District (Centre Region, Cameroon) despite implementation of complementary control strategies: Prospects for eliminat... by Hervé Kengne Fogang, Hugues C. Nana Djeunga, Alvine C. Kengne-Fokam, Murielle C. Tchami Mbagnia, Flobert Njiokou, Dickson S. Nsagha, Emmanuel Yenshu, Joseph Kamgno

“…The assessment of the impact of this package of interventions revealed that only a few individuals were still infected with Schistosoma mansoni. This study, therefore, aimed to investigate whether schistosomiasis transmission has been interrupted in the Ndikinimeki Health District by assessing the infection among the population of snails, intermediate hosts of schistosomiasis. …”
Get full text

Analysis of the dynamics of transition from non-colonization to colonization and Staphylococcus aureus bacteremia in hemodialysis patients using Markov models. [version 3; peer rev... by Difariney González-Gómez, J Natalia Jiménez, Johanna M Vanegas, Daniela Montoya-Urrego

“…In the 3-state model, it was found that patients colonized were more likely to develop S. aureus infection (13.9%). Conclusion A more likely transition from non-colonization to colonization was found, which increases with factors such as previous infection. …”
Get full text

Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) by V. T. Ivashkin, I. V. Maev, D. N. Andreev, O. V. Goloshchapov, A. A. Derinov, O. Yu. Zolnikova, K. V. Ivashkin, O. Yu. Kiseleva, A. P. Kiryukhin, O. S. Lyashenko, E. A. Poluektova, A. S. Tertychnyy, A. S. Trukhmanov, A. I. Ulyanin, A. A. Sheptulin, O. S. Shifrin

“…If drug treatment is ineffective or the patient has recurrent clostridial infection, fecal microbiota transplantation should be considered. …”
Get full text

Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii by Alban Hay, Willy Aucher, Romain Pigeault, Joanne Bertaux, Alexandre Crépin, Quentin Blancart Remaury, Yann Héchard, Ascel Samba-Louaka, Romain Villéger

“…We also explored the metabolome of A. castellanii infected or not with L. pneumophila. Among the 617 metabolites identified, four with reduced abundances during infection may be involved in antioxidant responses. …”
Get full text

Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15 by Syh-Jae Lin, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Wen-I Lee, Ji-Yih Chen, Jing-Long Huang

“…Natural killer cells and NKT-like cells are the first line immune defense against tumor and virus infection. Deficient NK and NKT-like cell effector function may contribute to increased susceptibility to infection in SLE patients. …”
Get full text

Korelasi antara Latent Membrane Protein-1 Virus Epstein-Barr dengan P53 pada Karsinoma Nasofaring (Penelitian Lanjutan) by Yenita ., Aswiyanti Asri

“…In endemic region, the causes of the NPC related to EBV infection. Latent and persistent EBV infection on NPC show tipe II latent pattern which showed by EBNA-1, LMP-1, 2 and EBER expression. …”
Get full text

Assessment of the application of the FA280—a fully automated fecal analyzer for diagnosing clonorchiasis: a mixed-method study by Si-Yue Huang, Qing-Sheng Zeng, Xin-Fu Shi, Yun-Ting He, Yue-Yi Fang, Ying-Si Lai

“…The agreement rate for positive results between the two methods was significantly higher in the high infection intensity group compared to the low infection intensity group (P < 0.05). …”
Get full text

Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Plasmodium falciparum Clinical Samples from Saudi Arabia by Saad M. Bin Dajem, Md Atique Ahmed, Marie Fe F Bohol, Syeda Wasfeea Wazid, Mohammed I. Shafeai, Fuad H. Rudiny, Ali M. Motaen, Kareem Morsy, Hani Alothaid, Ahmed A. Al-Qahtani

“…Plasmodium falciparum knob-associated histidine-rich proteins (PfKAHRPs) play an important role in cerebral malaria pathophysiology as well as pathogenesis of P. falciparum infections. The repeat region of PfKAHRP C-terminal interaction domain has been found to bind to the infected red blood cells and the vascular endothelium. …”
Get full text