Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…The GAS M1UK lineage has contributed significantly to the recently reported increases in scarlet fever and invasive infections. However, the basis for its evolutionary success is not yet fully understood. …”
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Comparing Campylobacter jejuni to three other enteric pathogens in OligoMM12 mice reveals pathogen-specific host and microbiota responses by Mathias K.-M. Herzog, Audrey Peters, Nizar Shayya, Monica Cazzaniga, Kardokh Kaka Bra, Trisha Arora, Manja Barthel, Ersin Gül, Luca Maurer, Patrick Kiefer, Philipp Christen, Katharina Endhardt, Julia A. Vorholt, Gad Frankel, Markus M. Heimesaat, Stefan Bereswill, Cormac G. M. Gahan, Marcus J. Claesson, Xavier Domingo-Almenara, Wolf-Dietrich Hardt

“…In this study, we applied the standardized gnotobiotic OligoMM12 microbiota mouse model and compared the infections in the same facility. We provide evidence of robust colonization and significant pathological changes in OligoMM12 mice following infection with these pathogens. …”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

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Construction and Pathogenicity Analysis of a GFPuv-labeled Peanut Ralstonia solanacearum Strain by Jinling HUANG, Yushuang WU, Huiquan TANG, Minyi HUANG, Ruixue YANG, Qiang WANG, Yong YANG, Xiaodan TAN

“…【Objective】The study aimed to construct a GFPuv-labeled peanut Ralstonia solanacearum, which was used to observe the infection pathway in host plants in real-time. Meanwhile, genomic integration sites suitable for exogenous gene were identified.…”
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CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against Escherichia coli by Thushari Gunawardana, Khawaja Ashfaque Ahmed, Kalhari Goonewardene, Shelly Popowich, Shanika Kurukulasuriya, Ruwani Karunarathana, Lisanework E. Ayalew, Ashish Gupta, Betty Lockerbie, Marianna Foldvari, Suresh K. Tikoo, Philip Willson, Susantha Gomis

“…We found that both 25 μg and 50 μg of CpG-ODN provided significant protection and reduced clinical scores compared to saline controls against E. coli infection. Overall, the present study revealed that CpG-ODNs orchestrate immunological niches in neonatal chickens in a dose-dependent manner that resulted in differential protection against E. coli infection, thus supporting a cause and effect relationship between CpG-ODN-induced immune enrichment and the antibacterial immunity.…”
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MANIFESTATION OF COVID-19 IN THE SECOND TRIMESTER OF PREGNANCY: FEATURES OF GESTATION, OBSTETRIC AND PERINATAL OUTCOMES by Людмила Станиславовна Ищенко, Екатерина Евгеньевна Воропаева, Элла Алексеевна Казачкова, Евгений Леонидович Казачков, Татьяна Николаевна Шамаева, Елена Романовна Вейсенборн, Юлия Сергеевна Ищенко

“…Information continues to accumulate about the characteristics of the course and outcomes of pregnancy and childbirth during the manifestation of the new coronavirus infection COVID-19. Most studies focus on the third trimester of gestation. …”
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The mechanism-specific injury mortality burden associated with heatwave in China in a warming world by Jianxiong Hu, Shaoli Huang, Yulin Zhuo, Jianhua Zhang, Weiwei Gong, Guanhao He, Maigeng Zhou, Fangfang Zeng, Ruilin Meng, Tao Liu, Chunliang Zhou, Yize Xiao, Min Yu, Biao Huang, Guoxia Bai, Hua Guo, Wenjun Ma

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Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

“…The organoid-based HRV-C infection model can be extended for developing antiviral strategies. …”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…The results from animal experiments indicated that PPR exhibited significant efficacy in a mouse enteritis model caused by ST infection, increasing the survival rate of mice infected with a lethal dose by 50%, reducing spleen colonization in infected mice, and alleviating tissue damage resulting from ST infection. …”
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Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of infected Balb/c WT and Balb/c IL-4−/− as well as its histopathological repercussions. …”
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Initial Presentation of Disseminated Coccidioidomycosis with Ocular Lesions by Edward J. Quinlan, Veenu Gill

“…Ocular involvement with disseminated coccidiodal infection is rare. Even rarer is a patient presenting with symptomatic chorioretinitis first, followed weeks later by systemic symptoms of disseminated coccidioidomycosis. …”
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Prevalence and Association of Malaria With the Blood Group on Febrile Patients at Woldia Comprehensive Specialized Hospital, Northeast Ethiopia by Wagaw Abebe, Fasikaw Wudu, Gebreeyesus Derib, Foziaya Fentie, Agenagnew Ashagre

“…Based on the findings of this study, we recommend that additional studies investigate the probable relationship between the ABO blood group phenotype and malaria infection.…”
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L’espace russe face au VIH by Daniel Mathieu

“…A special focus lies on HIV infection geography and on highly marked regional inequalities. …”
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Acute Obstructive Suppurative Pancreatic Ductitis in an Asymptomatic Patient by Eisha Wali, Patrick Koo, Clifford D. Packer

“…We present the first case of AOSPD in an asymptomatic patient with a polymicrobial infection and review the literature on this rare clinical entity.…”
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Human dirofilariasis – Unforeseen lesion in subcutaneous nodules: Case series from a tertiary care hospital, Wayanad by M M Gitanjali, Prasannakumar G Konapur, Hasaf Kolakkadan, K Nabeel Azeez

“…Human dirofilariasis is a type of zoonotic infection caused by the Dirofilarial species. It is a type of roundworm which is commonly seen in dogs, cats and is transmitted to humans by mosquito bite. …”
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Intussusception associated with rotavirus vaccination in a 2-month-old infant: A case report by Shu-Wei Hu, Min-Yung Kuo, Hueng-Chuen Fan

“…Most cases are idiopathic or caused by intestinal lymphadenopathy after viral infection. The rotavirus vaccine is a kind of oral live attenuated vaccine approved by the Department of Health in Taiwan since 2006. …”
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Disseminated Nocardia Otitidiscaviarum in a Patient with AIDS by Roger M Sandre, Richard C Summerbell

“…A case of disseminated infection due to Nocardia otitidiscaviarum is described in a Caucasian man infected with the human immunodeficiency virus. …”
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Occurence of infectious bovine rhİnotracheİÜs after pasîeurella haemolytica vaccinations by İrem Gütaçtı, Hakan Bulut

“…Considering high prevalance of IBR infection in our country, results of this study is very important.…”
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Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia by Julia Schearer, Christopher Merrick

“…Pneumocystis pneumonia (PCP) is a fungal infection with primary occurrence in immunocompromised individuals by the etiologic agent Pneumocystis jirovecii. …”
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Diet and Chronic Inflammation by Daniela Rivero-Mendoza, Wendy J. Dahl

“… Inflammation is your body's response to injury and infection—it's how your immune system helps to protect you from harm. …”
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