Machine learning models predicting risk of revision or secondary knee injury after anterior cruciate ligament reconstruction demonstrate variable discriminatory and accuracy perfor... by Benjamin Blackman, Prushoth Vivekanantha, Rafay Mughal, Ayoosh Pareek, Anthony Bozzo, Kristian Samuelsson, Darren de SA

“…Methods Three online databases (PubMed, MEDLINE, EMBASE) were searched from database inception to February 6, 2024, to identify literature on the use of machine learning to predict revision, secondary knee injury (e.g. anterior cruciate ligament (ACL) or meniscus), or reoperation in ACLR. …”
Get full text

Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until 20 March 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
Get full text

Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Mark Loeb, John Basmaji, Ya Gao, Maryam Ghadimi, Layla Bakaa, Luis Enrique Colunga Lozano, Saad Asif, Aninditee Das

“…We have therefore planned a systematic review and meta-analysis evaluating the impact of shorter versus longer durations of antibiotic therapy for patients with CAP.Methods and analysis We searched Ovid MEDLINE, Embase, CINAHL and Cochrane Central Register of Controlled Trials from inception to September 2021 for randomised controlled trials evaluating shorter versus longer duration of antibiotics. …”
Get full text

Effect of perioperative esketamine use on emergency delirium in children undergoing tonsillectomy and adenoidectomy: a systematic review and meta-analysis of randomized controlled... by Junfeng Liu, Jinming Liu, Hong Sun, Xue Cheng, Chunhui Wang, Daoyun Lei, Chao Han

“…The systematic review and meta-analysis was performed to investigate the effect of perioperative esketamine use on ED in children undergoing tonsillectomy and adenoidectomy.MethodWe searched Embase, The Cochrane Library, PubMed, MEDLINE, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang, VIP, and SinoMed from inception to 1 September, 2024. Two evaluators identified randomized controlled trials comparing perioperative use of esketamine with placebo or other drugs in children undergoing tonsillectomy and adenoidectomy. …”
Get full text

On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis by Zubair Khan, Yaseen Alastal, Muhammad Ali Khan, Mohammad Saud Khan, Basmah Khalil, Shreesh Shrestha, Faisal Kamal, Ali Nawras, Colin W. Howden

“…We searched MEDLINE, EMBASE, Web of Science, and Cochrane Library from inception until October 2, 2017, for randomized controlled trials (RCTs) comparing on-demand PPI versus placebo or daily PPI in the management of NERD or mild EE (Savary-Miller grade 1). …”
Get full text

Evaluation of Real-World Evidence to Assess Effectiveness Outcomes of Janus Kinase Inhibitors for Rheumatoid Arthritis: A Systematic Review of US Studies by Gandy C, Bazzazzadehgan S, Bruera S, Huang Y

“…Chandler Gandy,1 Shadi Bazzazzadehgan,1 Sebastian Bruera,2 Yinan Huang1 1Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, 38677 USA; 2Section of Immunology, Allergy & Rheumatology, Baylor College of Medicine, Houston, TX, USACorrespondence: Yinan Huang, Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Faser Hall 235, Oxford, MS, 38677, USA, Tel +1 (662) 915-2173, Email yhuang9@olemiss.eduObjective: This review summarized the real-world effectiveness outcomes of Janus kinase inhibitors (JAKi) for rheumatoid arthritis (RA) based on observational studies.Methods: A systematic review followed PRISMA guidelines, with searches conducted in PubMed, Embase, and CINAHL from each database’s inception to June 2, 2023. Studies were included if they evaluated real-world effectiveness outcomes of JAKi for US RA patients. …”
Get full text

Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia by Guihong Liu, Liangliang Sun, Peng Lv, Rong Qiao, Lihang Wang, Arong Jin

“…The search period covered from the inception of these databases to 4 August 2024. Articles were screened according to predefined inclusion and exclusion criteria, and meta-analysis was performed using Stata.ResultsA total of 25 articles were included in the analysis. …”
Get full text

Is it feasible to treat polycystic ovarian syndrome with or without insulin resistance using glucokinase activators as novel hypoglycaemic medications? A protocol for a systematic... by Xiaojing Liu, Lei Zeng, Shuo Yuan, Genping Zeng, Xijing Lu, Peiyin Li, Tan Zeng, Zitong Lin, Yuxi Miao

“…The search will encompass all available studies without language restrictions and cover the period from the inception of each database to 10 April 2024. Disputes will be resolved by talking with a third expert following the screening of articles and data extraction by two reviewers. …”
Get full text

Network Meta-Analysis of Different Acupuncture Therapies in Treatment of Low Back Myofascitis by GE Haiya, YAN Laijun, YANG Zongrui, SHI Jinyu, ZHAN Hongsheng

“…ObjectiveTo evaluate the efficacy of different acupuncture therapies for low back myofascitis through network meta-analysis.MethodsRandomized controlled trials (RCTs) of acupuncture therapy for low back myofascitis were retrieved from CNKI, Wanfang, VIP, PubMed, Embase, Cochrane Library from inception to April 2022. Outcome measures included overall efficiency and visual analogue scale (VAS). …”
Get full text

Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Inflammation plays a crucial role in the inception, advancement, and outcome of HF. Despite mounting evidence demonstrating the pivotal function of the NLRP3 inflammasome in HF, a thorough bibliometric examination of research focal points and trajectories in this domain has yet to be undertaken.Methods: Publications related to the NLRP3 inflammasome in HF were retrieved from the Web of Science database spanning 2010– 2024. …”
Get full text

Aetiology of vaginal discharge, urethral discharge, and genital ulcer in sub-Saharan Africa: A systematic review and meta-regression. by Julia Michalow, Magdalene K Walters, Olanrewaju Edun, Max Wybrant, Bethan Davies, Tendesayi Kufa, Thabitha Mathega, Sungai T Chabata, Frances M Cowan, Anne Cori, Marie-Claude Boily, Jeffrey W Imai-Eaton

“…<h4>Methods and findings</h4>We searched Embase, MEDLINE, Global Health, Web of Science, and grey literature from inception until December 20, 2023, for observational studies reporting aetiologic diagnoses among symptomatic populations in SSA. …”
Get full text

Systematic Evaluation and Trial Sequential Analysis of Therapeutic Effect of Needle Knife <italic>Versus</italic> Acupuncture on Cervical Spondylosis of Cervical Type by HUANG Bowei, CHEN Bin, CHEN Yinzhu, ZHAO Yingrong, ZHAO Hongjia

“…ObjectiveTo systematically evaluate the effectiveness and safety of needle-knife in the treatment of cervical spondylosis of cervical type.MethodsThe VIP databases, Wanfang Data, CNKI, PubMed, and the Cochrane Library database were searched from inception to June 30, 2021. The clinical randomized controlled trials (RCTs) of needle-knife versus acupuncture (combined with other treatments) in the treatment of cervical spondylosis were included . …”
Get full text

Human intestinal nematode infections in Sri Lanka: A scoping review. by Nalini Kaushalya Jayakody, Anjana Silva, Susiji Wickramasinghe, Nilanthi de Silva, Sisira Siribaddana, Kosala Gayan Weerakoon

“…<h4>Methodology</h4>We reviewed published information on HINIs in Sri Lanka in electronic databases, local journals and grey literature from inception to September 2022. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-Scr), a systematic strategy was used for searching, screening, reviewing and data extraction. …”
Get full text

Perioperative management for people with chronic kidney disease receiving dialysis undergoing major surgery: a protocol for a scoping review by Paul E Ronksley, Matthew James, Janine F Farragher, Brenda R Hemmelgarn, Shannon M Ruzycki, Maoliosa Donald, Tyrone G Harrison, Connor O'Rielly, Deirdre McCaughey, Kelly B Zarnke

“…In February 2020, we will complete our search of MEDLINE, EMBASE, CINAHL Plus, Cochrane Database of Systematic Reviews, and Cochrane Controlled Trials Registry for published literature from inception to present. All study types are eligible for inclusion, without language restriction. …”
Get full text

Rituximab-associated adverse events in nephrotic syndrome: A systematic review and meta-analysis by Zixian Yu, Meijin Huang, Yunlong Qin, Xiayin Li, Yueru Zhao, Yuwei Wang, Yumeng Zhang, Anjing Wang, Mei Han, Jin Zhao, Shiren Sun

“…Methods: PubMed, Embase, and the Cochrane Register of Controlled Trials databases were searched from inception to December 31, 2023, for randomized control trials (RCTs) and retrospective studies reporting the adverse events (AEs) related to RTX for treating NS. …”
Get full text

Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials by Russell J de Souza, Lawrence Mbuagbaw, John L Sievenpiper, Dena Zeraatkar, Laura Banfield, Vanessa Ha, David J A Jenkins, Jhalok Ronjan Talukdar, Matthew Adam Cooper, Lyuba Lyutvyn, Rahim Ali, Rachel Bierbrier, Sabrina Janes, Pauline B Darling

“…Introduction This review aims to assess the effects of dietary supplementation with inulin-type fructans (ITF) compared with no supplementation on cardiovascular disease risk factors in adults and assess the quality of trial reporting using the Consolidated Standards of Reporting Trials (CONSORT) and CONSORT for abstract (CONSORT-A) checklists.Methods and analysis We will search randomised controlled trials (RCTs) in MEDLINE, EMBASE, CINAHL, Emcare, AMED and the Cochrane Database of Systematic Reviews from inception to 31 March 2022, without any language restrictions. …”
Get full text

Aldosterone Blockade in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis by Qiao Chen, Die Zhao, Jie Sun, Chengzhi Lu

“…Articles were identified through PubMed, Embase, Cochrane Library, Ovid (Medline1946-2021), and ClinicalTrials.gov databases from their inception to December 31, 2020. Results. 15 articles with a total of 11,861 patients were included. …”
Get full text

Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

“…Methods: We searched three repositories from database inception up to October 1, 2023 and we included meta-analyses of observational studies reporting data on the use of LB, compared to gold standard, and its accuracy (area under the curve, AUC). …”
Get full text

Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level by Giusy Rita Maria La Rosa, Alejandro Ismael Lorenzo-Pouso, Vito Carlo Alberto Caponio, Mariangela Valentina Puci, Mariangela Valentina Puci

“…Electronic (Embase, PubMed, Scopus, Web of Science) and manual literature searches were conducted from inception to 31 October, 2023 (updated in August, 2024). …”
Get full text

Effectiveness of Traditional Chinese Medicine in Psychological Rehabilitation After Lung Cancer Surgery: Systematic Review and Meta-Analysis protocol by Luchang Cao PhD, Zilin Wang MM, Xinmiao Wang PhD, Guanghui Zhu PhD, Ying Zhang PhD, Jie Li PhD

“…Search for studies published from the inception of each database until April 22, 2024. This study will be limited to clinical randomized controlled trials (RCTs). …”
Get full text