Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Mechanistically, TFF3 was observed to activate c-MET signaling through a positive-feedback loop to enhance the CSC-like phenotype of ER+HER2+ MC. …”
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High rate of false positive malaria rapid diagnostic tests in a district hospital in Uganda by Susanne E. Mortazavi, Susanne E. Mortazavi, Allan Lugaajju, Anna-Clara Ivarsson, Sara Karlsson Söbirk, Sara Karlsson Söbirk, Hans Norrgren, Hans Norrgren, Kristina E. M. Persson, Kristina E. M. Persson

“…This study aimed to evaluate the diagnostic accuracy of RDT compared to microscopy and loop-mediated isothermal amplification (LAMP) in a malaria-endemic region of Uganda.MethodsA prospective study was conducted with 225 febrile individuals diagnosed with malaria using RightSign Malaria Ag HRPII/Pan Plasmodium Aldolase RDT (Hangzhou Biotest Biotech Co., Ltd., China) at Iganga General Hospital, Uganda. …”
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ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling by Jiaxuan Sui, Qianlan Yin, Yiying Chen, Min Sun, Xianzheng Yuan, Zhaojun Ding, Xiangpei Kong

“…Furthermore, the transcription of ERF114/115/109 is induced by JA in an MYC2-dependent manner, thus forming a positive feedback loop in JA signaling. Collectively, this study reveals a regulatory pathway in which ERF114/115/109 regulate JA signaling by targeting non-canonical JAZ proteins.…”
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Associations of the Need for Surgery in Emergency Department Patients with Small Bowel Obstructions by Daniel J. Berman, Alexander W. Mahler, Ryan C. Burke, Andrew E. Bennett, Nathan I. Shapiro, Leslie A. Bilello

“…We identified seven independent associations for the decision of surgery: abdominal distension (OR 0.27, 95% CI 0.10–0.62); gastrografin (OR 0.41, 95% CI 0.20–0.81); previous SBO (OR 0.42, 95% CI 0.26–0.66); higher Charlson Comorbidity Index score (OR 0.87, 95% CI 0.80–0.95); nasogastric decompression (OR 2.04, 95% CI 1.25–3.39), initial systolic blood pressure <100 mm Hg (OR 2.65, 95% CI 1.05–6.53); free fluid or volvulus/closed-loop obstruction on computed tomography (OR 7.95, 95% CI 4.25–15.39), with the AUC for the predictive model equaling 0.73. …”
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Prognostic relevance of Ki-67 and P16/INK4a markers in histological diagnosis of cervical dysplasia by T. A. Dimitriadi, D. V. Burtsev, E. A. Dzhenkova, T. N. Gudtskova, K. V. Dvadnenko

“…The use of IHC in the initial diagnosis will contribute to: improving the information content of multiple aimed and loop excisional biopsies; reduction in relapse due to inadequate treatment; eliminating the unreasonable use of such a traumatic method as conization (especially in women of childbearing age).…”
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Visual, clinical and quality of life outcomes of a new multifocal IOL with optimized diffractive grating: a non-randomized clinical trial by João Marcelo de Almeida Gusmão Lyra, Mariana Silva Gois de Almeida, Lucila de Albuquerque Barbosa Lira, Laís Oliveira dos Santos, Mateus Lins dos Santos, Jorge Artur Peçanha de Miranda Coelho

“…The BIOS Trifocal is a single-piece acrylic diffractive IOL with a closed-loop haptic design, optimized for centration and stability. …”
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Minimally invasive internal splinting technique for acute closed Achilles tendon rupture by Songlin Liu, Liang Ma

“…Results We bridged the intact portion of the Achilles tendon proximal to the rupture site and the calcaneal bone using a Krackow locking loop suture technique and a knotless anchor staple technique. …”
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Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II by Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris

“…According to the docking results, two probable sites of binding for uncompetitive inhibitors were highlighted in the wider area of the active site and in the propeller loop. <b>Conclusions:</b> Potent inhibitors with IC₅₀ at the nM range and competitive, non-competitive, uncompetitive, and mixed modes of action, one better than sitagliptin, were found. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…GPN3, an evolutionarily conserved member of the GPN-loop GTPase subfamily classified in 2007 according to its structure, has limited knowledge regarding its cellular functions and molecular mechanisms. …”
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Empowering Particle Jamming Soft Gripper with Tactility via Stretchable Optoelectronic Sensing Skin by Liyan Mo, Wenhao Xie, Jingting Qu, Jiutian Xia, Yunquan Li, Yuanfang Zhang, Tao Ren, Yang Yang, Juan Yi, Changchun Wu, Yonghua Chen

“…Furthermore, it can effectively detect the slippage of grasped objects, facilitating accurate closed‐loop control for secure manipulation.…”
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Hospital pharmacy implementation of a unit dose dispensing system: A qualitative interview study to determine experiences, views and attitudes of nursing staff by Theodora Steindl-Schönhuber, Theresa Drechsel, Gunda Gittler, Anita Elaine Weidmann

“…The Unit-Dose-Dispensing-System (UDDS) is an essential element of the “Closed Loop Medication Management System” that enables the tracking of single medication items across the entire medication workflow thereby improving transparency, patient safety and healthcare efficiency”. …”
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Distributed representations enable robust multi-timescale symbolic computation in neuromorphic hardware by Madison Cotteret, Hugh Greatorex, Alpha Renner, Junren Chen, Emre Neftci, Huaqiang Wu, Giacomo Indiveri, Martin Ziegler, Elisabetta Chicca

“…Our approach is validated through simulations with highly nonideal weights; an experimental closed-loop memristive hardware setup; and on Loihi 2, where it scales seamlessly to large state machines. …”
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IbI logics optimization algorithm-based high-order sliding mode control for DSIG within a wind turbine system by Khaled Benzaoui, Abderrahmen Bouguerra, Samir Zeghlache, Ahmed Elsanabary, Saad Mekhilef, Ahmed Bendib, Houssam eddine Ghadbane, Hegazy Rezk

“…The effectiveness of the proposed control approach is assessed based on a hardware-in-the-loop (HIL) implementation in a PLECS/RT Box real-time simulator. …”
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Viable Ileosigmoid Knotting, A Very Phenomenon Finding and Rare Cause of Intestinal Obstruction: A Case Report and Literature Review by Beyene SA, Bogale NT, Abdinasir MM, Desalegne AZ, Wossen MA

“…It is a hyperactive segment of ileum that winds around the pedicle of the redundant sigmoid colon, resulting in a closed-loop obstruction. There are different classification schemes of ileosigmoid knotting depending on the active component of the knot and based on the viability of the bowel and physiology of the patient. …”
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Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers by Julia C. Spinelli, Brandon J. Suleski, Donald E. Wright, Joseph L. Grow, Gabriel R. Fagans, Maura J. Buckley, Da Som Yang, Kaitao Yang, Steven M. Beil, Jessica C. Wallace, Thomas S. DiZoglio, Jeffrey B. Model, Shirley Love, David E. Macintosh, Alan P. Scarth, Matthew T. Marrapode, Corinna Serviente, Raudel Avila, Barrak K. Alahmad, Michael A. Busa, John A. Wright, Weihua Li, Douglas J. Casa, John A. Rogers, Stephen P. Lee, Roozbeh Ghaffari, Alexander J. Aranyosi

“…Here we present a closed-loop electrochemical/biophysical wearable sensing device and algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, and sodium loss with electrode arrays embedded in a microfluidic channel. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…Additionally, during increased inflammatory responses or Th17 cell differentiation, USP25 expression is activated, forming a negative feedback regulatory loop that attenuates immune activation.…”
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A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer by Xiannan Meng, Qingxuan Wu, Chengsong Cao, Wendong Yang, Sufang Chu, Hongjun Guo, Suhua Qi, Jin Bai

“…Results A novel ENZ-resistant circRNA, circSRCAP, was identified and shown to be upregulated in ENZ-resistant C4-2B (ENZR-C4-2B) cells, correlating with increased AR-V7 protein levels. circSRCAP is generated via splicing by eIF4A3, forming a loop structure and is exported from the nucleus by the RNA helicase DDX39A. …”
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Collapsing Pattern Class-IV Lupus Nephritis Presenting as Posterior Reversible Encephalopathy Syndrome and Cardiac Tamponade: A Rare COVID-19 Sequelae by K Harshitha Reddy, Pranjal Kashiv, Sunil Kumar, Sourya Acharya, Kapil Navin Sejpal

“…It is divided into two types: diffuse segmental and the other being diffuse global. Wire-loop lesions could also be observed. There have been reports of Collapsing Glomerulopathy (CG) in SLE patients with Focal Segmental Glomerulosclerosis (FSGS). …”
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Effect of Low-Frequency Vibration on Muscle Response under Different Neurointact Conditions by Chaofei Zhang, Wenjun Wang, Dennis Anderson, Sishu Guan, Guofa Li, Hongyi Xiang, Hui Zhao, Bo Cheng

“…The tension-length curve was found to be a nonlinear hysteresis loop that changed with frequency. The phase difference between the dynamic muscle force and the length change was affected significantly by vibration frequency (p<0.01), and the minimum frequency was 4–8 Hz. …”
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The MIR181A2HG/miR‐5680/VCAN‐CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization by Weijie Zang, Yongpu Yang, Junjie Chen, Qinsheng Mao, Wanjiang Xue, Yilin Hu

“…On the other hand, VCAN binds to CD44 receptors on the surface of GC cells through autocrine secretion, activating the Hippo pathway and upregulating SP1, thereby promoting the transcription of MIR181A2HG and establishing a feedback loop driving lymphatic metastasis. Conclusion This study highlights the pivotal role of MIR181A2HG in GC progression and LNs metastasis. …”
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