Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…Abstract The generation of retinal models from human induced pluripotent stem cells holds significant potential for advancing our understanding of retinal development, neurodegeneration, and the in vitro modeling of neurodegenerative disorders. The retina, as an accessible part of the central nervous system, offers a unique window into these processes, making it invaluable for both study and early diagnosis. …”
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Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

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Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium by Weikang Lv, Haoran Yu, Abdellah Aazmi, Tuya Naren, Wanli Cheng, Mengfei Yu, Zhen Wang, Xiaobin Xu, Huayong Yang, Liang Ma

“…Constructing an in vitro vascularized liver tissue model that closely simulates the human liver is crucial for promoting cell proliferation, mimicking physiological heterogeneous structures, and recreating the cellular microenvironment. …”
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THE MAIN REASONS OF THE LOW EFFICIENCY OF OBTAINING ALUMINUM-RESISTANT REGENERANTS OF CEREAL CROPS by E. M. Lisitsyn

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Review: Will “cultured meat” transform our food system towards more sustainability? by Jean-François Hocquette, Sghaier Chriki, Dominique Fournier, Marie-Pierre Ellies-Oury

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Mechanistic switch in corrosion behavior of magnesium alloy diamond lattice structures induced by argon plasma treatment by Viviana M. Posada, Alexandru Marin, Tonny Naranjo, Juan Ramírez, Patricia Fernández-Morales

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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…Here, we investigated the in vitro effects of the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil on human pancreatic PANC-1 and colorectal SW-620 cancer cell lines to understand further cellular behaviors and the potential risks of their use in cancer therapy. …”
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Insights into the relations between cell wall integrity and in vitro digestion properties of granular starches in pulse cotyledon cells after dry heat treatment by Ping Li, Bin Zhang, Rui Liu, Li Ding, Xiong Fu, Haiteng Li, Qiang Huang, Xiaowei He

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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

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Comprehensive Physicochemical Characterization and in Vitro Human Cell Culture Studies of an Innovative Biocompatible and Biodegradable Silk-Derived Protein Hydrolysate, SDP‑4 by Hasham Shafi, Andrea J. Lora, Saurabh Aggarwal, David W. Infanger, Brian D. Lawrence, Heidi M. Mansour

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Enhancing DNA Vaccine Delivery Through Stearyl-Modified Cell-Penetrating Peptides: Improved Antigen Expression and Immune Response In Vitro and In Vivo by Sheng Jiang, Cheng Zu, Bin Wang, Yiwei Zhong

“…Background: Inefficient cellular uptake is a significant limitation to the efficacy of DNA vaccines. …”
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Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway in vitro and in vivo by Guanqi Liu, Jiahui Lin, Xiaoyan Chen, Runheng Liu

“…These findings highlight the importance of considering the cellular microenvironment in tissue engineering and regenerative medicine and suggest potential targets for modulating MMSCs behavior to enhance bone regeneration.…”
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<i>Rosa damascena</i> Mill. Essential Oil: Analysis of In Vitro and In Vivo Genotoxic and Cytotoxic Potentials by Employing Three Cytogenetic Endpoints by Tsvetelina Gerasimova, Svetla Gateva, Gabriele Jovtchev, Tsveta Angelova, Margarita Topashka-Ancheva, Ana Dobreva, Milka Mileva

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In vitro and molecular docking evaluation of black sesame seeds' anti-prostate cancer and antioxidant activity processed by nine steaming nine drying by Glennielyn D. Magdamit, Cheng-Yang Hsieh, Mon-Juan Lee, Kathlia A. De Castro-Cruz, Samantha Franchette B. Austria, Beatrice D. Sipat, Steven Kuan-Hua Huang, Po-Wei Tsai

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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…However, the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased influences. …”
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Characterization and effective expansion of CD4−CD8− TCRαβ+ T cells from individuals living with type 1 diabetes by J. Ernesto Fajardo-Despaigne, Félix Lombard-Vadnais, Adam-Nicolas Pelletier, Aïnhoa Olazabal, Lucie Boutin, Sarah Pasquin, Valérie Janelle, Laurent Legault, Jean-Sébastien Delisle, Erin E. Hillhouse, Lise Coderre, Sylvie Lesage

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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Eventually, in vivo and vitro experiments demonstrated that GADD45B overexpression was partially mediated by CS-induced DNA hypomethylation. …”
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Enhancing in Vitro anti-metastatic efficacy and deep penetration into tumor spheroid of docetaxel-loaded liposomes via size optimization for prostate cancer treatment by Saksorn Klibaim, Nutthanit Thumrongsiri, Natsorn Watcharadulyarat, Walailuk Chonniyom, Prattana Tanyapanyachon, Paweena Dana, Nattika Saengkrit

“…Therefore, this study explored the potential of size-optimization of docetaxel-loaded liposomes (LDTX) to improve in vitro efficacy against CRPC. The impacts of LDTX size (<100 nm and 100–200 nm) on cellular uptake, cytotoxicity in both monolayer and three-dimensional (3D) tumor spheroid models, and anti-metastatic effects were investigated. …”
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In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage by Ian Hare, Marieta Gencheva, Rebecca Evans, James Fortney, Debbie Piktel, Jeffrey A. Vos, David Howell, Laura F. Gibson

“…To investigate the response to DSB stress with passage in vitro, primary human MSCs were exposed to etoposide (VP16) at various passages with subsequent evaluation of cellular damage responses and DNA repair. …”
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Ameliorative Effects of Raisin Polyphenol Extract on Oxidative Stress and Aging In Vitro and In Vivo via Regulation of Sirt1–Nrf2 Signaling Pathway by Wenjing Gao, Caiyun Zhao, Xin Shang, Bin Li, Jintian Guo, Jingteng Wang, Bin Wu, Yinghua Fu

“…In summary, RP exerted antioxidant and anti-aging effects via regulating the Sirt1–Nrf2 signaling pathway in vitro and in vivo.…”
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