Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism by Bartlomiej Taciak, Maciej Bialasek, Malgorzata Kubiak, Ilona Marszalek, Malgorzata Gorczak, Olha Osadchuk, Daria Kurpiel, Damian Strzemecki, Karolina Barwik, Marcin Skorzynski, Julia Nowakowska, Waldemar Lipiński, Łukasz Kiraga, Jan Brancewicz, Robert Klopfleisch, Łukasz Krzemiński, Emilia Gorka, Anna Smolarska, Irena Padzinska-Pruszynska, Małgorzata Siemińska, Jakub Guzek, Jan Kutner, Marlena Kisiala, Krzysztof Wozniak, Giacomo Parisi, Roberta Piacentini, Luca Cassetta, Lesley M. Forrester, Lubomir Bodnar, Tobias Weiss, Alberto Boffi, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Krol

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Fabry cardiomyopathy: Gb3‐induced auto‐reactive panmyocarditis requiring heart transplantation by Andrea Frustaci, Maurizio Scarpa, Rosalia Maria da Riol, Chiara Agrati, Nicoletta Finato, Romina Verardo, Claudia Grande, Cristina Chimenti, Concetta Di Nora, Matteo Antonio Russo, Ugolini Livi

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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…RT-PCR assays were used to test the GRK6 expression in human BC tissues and cell lines. The in vitro cellular migration and in vivo lung colony-forming assays were established to estimate the metastatic potentials of TNBC cells. …”
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Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition by Linli Yao, GuangHui Zi, Miao He, Yuhong Xu, Lulu Wang, Baowei Peng

“…Our findings demonstrate that AEP regulates cellular autophagy by modulating lysosomal function through its control over endo/lysosomal PI3K activity. …”
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Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

“…Therefore, one of the important tasks is generation of an in vitro model system of Huntington’s disease based on human cell cultures. …”
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Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC by Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu, Zhe Liu, Zhe Liu

“…Autophagy, a conserved cellular process, is implicated in many cancers, but its role in SCLC remains unclear.MethodsUsing a genetically engineered mouse model (Rb1fl/fl; Trp53fl/fl; GFP-LC3-RFP-LC3△G), we tracked autophagic flux in vivo to investigate its effects on SCLC biology. …”
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Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review by Mardiana L, Milanda T, Hadisaputri YE, Chaerunisaa AY

“…It focuses on findings from preclinical and in vitro studies that examine the pharmacokinetic enhancements provided by phytosome technology when applied to secondary metabolites.Results: Phytosome-encapsulated secondary metabolites exhibit significantly improved solubility, absorption, distribution, and cellular uptake compared to non-encapsulated forms. …”
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NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses by Sijun Li, Ningyuan Chen, Junrui He, Xibao Luo, Wei Lin

“…BackgroundProgrammed cell death plays an important role in neuronal injury and death after ischemic stroke (IS), leading to cellular glucose deficiency. Glucose deficiency can cause abnormal accumulation of cytotoxic disulfides, resulting in disulfidptosis. …”
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Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug by Fengbo Wu, Ting Xu, Chi Liu, Can Chen, Xiangrong Song, Yu Zheng, Gu He

“…The physicochemical properties of the PTX loaded GA-PEG-GA micelles were evaluated including in vitro cellular uptake, cytotoxicity, drug release profile, and in vivo tissue distribution. …”
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Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats by Mirko Rehberg, Timo Kirschstein, Xiati Guli, Steffen Müller, Marco Rohde, Denise Franz, Tursonjan Tokay, Rüdiger Köhling

“…Hence, studying the cellular and molecular cascades involved in the key mechanism of information storage in the brain, synaptic plasticity, has led to enormous knowledge in this field. …”
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Biochemical Analysis of Histone Succinylation by Atsushi Yokoyama, Shogo Katsura, Akira Sugawara

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Liposomal Antioxidants for Protection against Oxidant-Induced Damage by Zacharias E. Suntres

“…Overproduction and/or insufficient removal of ROS result in significant damage to cell structure and functions. In vitro studies showed that antioxidants, when applied directly and at relatively high concentrations to cellular systems, are effective in conferring protection against the damaging actions of ROS, but results from animal and human studies showed that several antioxidants provide only modest benefit and even possible harm. …”
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A mutation in porcine pre-miR-15b alters the biogenesis of MiR-15b\16-1 cluster and strand selection of MiR-15b. by Wenyang Sun, Jing Lan, Lei Chen, Jinjie Qiu, Zonggang Luo, Mingzhou Li, Jinyong Wang, Jiugang Zhao, Tinghuan Zhang, Xi Long, Jie Chai, Zunqiang Yan, Zongyi Guo, Shuangbao Gun

“…MiR-15b plays an important role in cellular proliferation, apoptosis and the cell cycle. …”
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Seaweed nutraceuticals and their therapeutic role in disease prevention by Abirami R. Ganesan, Uma Tiwari, Gaurav Rajauria

“…It presents an update on the most recent evidence relating to their effect on health-related conditions and their action on cellular metabolism. Recent advancement and challenges for seaweed bioactive as a nutraceutical in relation to their biocompatibility and bioavailability to understand their therapeutic development is discussed. …”
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Flow-based In Vivo Method to Enumerate Translating Ribosomes and Translation Elongation Rate by Mina Seedhom, Devin Dersh, Jonathan Yewdell

“…Protein synthesis is by far the most energetically costly cellular process in rapidly dividing cells. Quantifying translating ribosomes in individual cells and their average mRNA transit rate is arduous. …”
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Immunogenic Evaluation of Ribosomal P-Protein Antigen P0, P1, and P2 and Pentameric Protein Complex P0-(P1-P2)2 of Plasmodium falciparum in a Mouse Model by Agnieszka Szuster-Ciesielska, Leszek Wawiórka, Dawid Krokowski, Nikodem Grankowski, Łukasz Jarosz, Urszula Lisiecka, Marek Tchórzewski

“…We determined the level of cellular- and humoral-type immunological response followed by development of specific immunological memory. …”
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Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy by Cheng-Zhi Wang, Robert A. Kazmierczak, Abraham Eisenstark

“…Recently, investigation of bacterial-based tumor therapy has regained focus due to progress in molecular, cellular, and microbial biology. Many bacteria such as Salmonella, Listeria, Escherichia, and Clostridium have proved to have tumor targeting and in some cases even tumor-destroying phenotypes. …”
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Impact of artificial meat as novel food: controversies and future perspectives by Marco Cintoni, Marta Palombaro, Gabriele Egidi, Elena Leonardi, Federica Gardin, Gabriele Pulcini, Emanuele Rinninella, Pauline Raoul, Maria Cristina Mele

“…Artificial meat, also called «synthetic», «cultured», or «in-vitro» meat, is growing in interest worldwide as a possible alternative protein source to regular meat derived from farm animals. …”
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Coordination of transporter, cargo, and membrane properties during non-vesicular lipid transport by Alena Ballekova, Andrea Eisenreichova, Bartosz Różycki, Evzen Boura, Jana Humpolickova

“…Abstract Homeostasis of cellular membranes is maintained by fine-tuning their lipid composition. …”
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Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing. by Tiana M Scott, Lydia M Arnold, Jordan A Powers, Delaney A McCann, Ana B Rowe, Devin E Christensen, Miguel J Pereira, Wen Zhou, Rachel M Torrez, Janet H Iwasa, Philip J Kranzusch, Wesley I Sundquist, Jarrod S Johnson

“…Strikingly, the capsid inhibitor lenacapavir also disrupted viral cores and dramatically potentiated cGAS activity, both in vitro and in cellular infections. Our results provide biochemical evidence that the HIV-1 capsid lattice conceals the genome from cGAS and that chemical or physical disruption of the viral core can expose HIV-1 DNA and activate innate immune signaling.…”
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