Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases by Alexander Desuki, Frank Staib, Ines Gockel, Markus Moehler, Hauke Lang, Stefan Biesterfeld, Annett Maderer, Peter R. Galle, Martin R. Berger, Carl C. Schimanski

“…Loss of LLGL1 has been associated with loss of cellular adhesion and dissemination of cells from colorectal cancer and malignant melanoma. …”
Get full text

Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…In renal diseases, in which “chronic inflammation” or “the overstimulation of cellular immunity” is responsible for the pathogenesis, the overexpression of Kv1.3-channels in lymphocytes promotes their cellular proliferation and thus contributes to the progression of tubulointerstitial fibrosis. …”
Get full text

Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery by Alice Rockliffe, Lauren Wheeler, Kiran Lidhar, Arun Dhar, Michelle Pemberton, Richard Kasprowicz, Ceridwen Hopely, Jo Francis, Shane Marine, David Brierley, Lorna Suckling

“…At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). …”
Get full text

M-Sec promotes the accumulation of intracellular HTLV-1 Gag puncta and the incorporation of Env into viral particles. by Masateru Hiyoshi, Youssef M Eltalkhawy, Randa A Abdelnaser, Akira Ono, Kazuaki Monde, Yosuke Maeda, Reem M Mahmoud, Naofumi Takahashi, Yasuyoshi Hatayama, Akihide Ryo, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota, Shinya Suzu

“…We have demonstrated that the cellular protein M-Sec promotes the transmission of human T-cell leukemia virus type 1 (HTLV-1) in vitro and in vivo. …”
Get full text

Role of CEACAM1, ECM, and Mesenchymal Stem Cells in an Orthotopic Model of Human Breast Cancer by Sridhar Samineni, Carlotta Glackin, John E. Shively

“…Carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is a morphogen in an in vitro model for lumen formation and plays a similar role in breast epithelial cells implanted in humanized mammary fat pads in NOD-SCID mice. …”
Get full text

Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering by Francesca Di Filippo, Tiziana A. L. Brevini, Georgia Pennarossa, Fulvio Gandolfi

“…Cellular compartment removal and extracellular matrix preservation are evaluated. …”
Get full text

The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation by Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

Get full text

Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis by Tao Jiang, Jinhong Xu, Yang Lu, Xiaojin Chen, Yongxia Li

“…In addition, in the cellular model, real-time reverse transcriptase-polymerase chain reaction (Real-Time RT-PCR) and enzyme-linked immunosorbent assay (ELISA) results showed that AA could alleviate alcohol-induced cellular inflammation, while western blot and immunofluorescence results showed that AA might alleviate alcohol-induced cellular inflammation by inhibiting the nuclear factor-κB (NF-κB) pathway. …”
Get full text

PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress by Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

“…Abstract Aging is characterized by cellular degeneration and impaired physiological functions, leading to a decline in male sexual desire and reproductive capacity. …”
Get full text

Challenges in observing transcription–translation for bottom-up synthetic biology by Vadim G. Bogatyr, Gijs J. L. Wuite

“…However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and how to track their function. …”
Get full text

Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity by Lynn A. C. Devilée, Abou bakr M. Salama, Jessica M. Miller, Janice D. Reid, Qinghui Ou, Nourhan M. Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Todd K. Rosengart, Douglas Andres, Jonathan Satin, Tamer M. A. Mohamed, James E. Hudson, Riham R. E. Abouleisa

“…Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. …”
Get full text

Polymer Design of Microwell Hydrogels Influences Epithelial–Mesenchymal Interactions During Human Bronchosphere Formation by Madeline K. Eiken, Justin E. Levine, Shinyeong Lee, Samantha Lukpat, Eleanor M. Plaster, Vikram Bala, Jason R. Spence, Claudia Loebel

“…Bronchospheres have emerged as a promising in vitro model toward probing questions on organ development and disease. …”
Get full text

Dual Probe with Fluorescent and Magnetic Properties for Imaging Solid Tumor Xenografts by Liang Shan, Songping Wang, Rajagopalan Sridhar, Zaver M. Bhujwalla, Paul C. Wang

“…Confocal microscopy, optical imaging, and MRI showed a dramatic increase of in vitro cellular uptake of the fluorescent and magnetic reporter groups from the probe compared with the uptake of contrast agent or Lip-CA alone. …”
Get full text

Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. by Alison K Gillingham, Sean Munro

“…One of the most well characterised of these G proteins is mammalian Arf6, a protein that participates in many cellular processes including endocytosis, actin remodelling and cell adhesion. …”
Get full text

Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu by Natalia P. Rodina, Maksim I. Sulatsky, Anna I. Sulatskaya, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

“…Such crowded cellular milieu is typically simulated in vitro using concentrated solutions of inert polymers, which do not usually interact with proteins. …”
Get full text

Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair by Gurleen Kaur, Chuanxi Cai

Get full text

Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer by Lanning Bai, Xueqian Qian, Hui Zhang, Yi Yuan, Xiaodong Cui, Min Cheng, Yangyang Han

“…Results In this study, our findings demonstrate that PLEC exerts a positive influence on the progression of OC, encompassing cellular proliferation, migration, invasion, and adhesion both in vitro and in vivo. …”
Get full text

Electrochemical impedance spectroscopy as a micropropagation monitoring tool for plants: A case study of tamarillo Solanum betaceum callus by André Caeiro, Jorge Canhoto, Paulo R.F. Rocha

“…Summary: Tamarillo is an economically important species that has been extensively studied in terms of in vitro morphogenesis and micropropagation techniques, including somatic embryogenesis. …”
Get full text

Nestin Forms a Flexible Cytoskeleton by Means of a Huge Tail Domain That Is Reversibly Stretched and Contracted by Weak Forces by Ayana Yamagishi, Rina Tokuoka, Kazuki Imai, Mei Mizusawa, Moe Susaki, Koki Uchida, Saku T. Kijima, Akira Nagasaki, Daijiro Takeshita, Chiaki Yoshikawa, Taro Q. P. Uyeda, Chikashi Nakamura

Get full text

Glycosylation of ceramide synthase 6 is required for its activity by Alexandra J. Straus, Grace Mavodza, Can E. Senkal

“…Sphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis. …”
Get full text