Efeitos da Covid-19 na Atenção ao Câncer no Brasil: Impactos do Rastreamento ao Tratamento by Caroline Madalena Ribeiro, Adriana Tavares de Moraes Atty

“…Frequências mensais de casos confirmados de covid-19 e procedimentos de rastreamento dos cânceres de mama e do colo do útero, diagnóstico e tratamento de todos os tipos de câncer foram calculadas para o ano pré-pandêmico (2019) e o período pandêmico (2020-2022). …”
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Fetal-BET: Brain Extraction Tool for Fetal MRI by Razieh Faghihpirayesh, Davood Karimi, Deniz Erdogmus, Ali Gholipour

“…Fetal MRI has played a crucial role in prenatal neurodevelopmental studies and in advancing our knowledge of fetal brain development <italic>in-utero</italic>. Fetal brain extraction is a necessary first step in most computational fetal brain MRI pipelines. …”
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Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity by Maïlis Darmuzey, Franck Touret, Emily Slowikowski, Ivan Gladwyn-Ng, Karan Ahuja, Lorena Sanchez-Felipe, Xavier de Lamballerie, Catherine Verfaillie, Pedro E. Marques, Johan Neyts, Suzanne J. F. Kaptein

“…Our study reveals that Asian ZIKV strains evolved towards pathogenic attenuation, potentially resulting in CZS emergence in neonates rather than premature death in utero.…”
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Caracterización de la mortalidad por cáncer en la provincia de Cienfuegos. 2010-2011 by María Magdalena Basanta Molina, Lucía Hernández Torres, Hilda María Delgado Acosta, Nicolás Ramón Cruz, José Nicolás Toledo Torres, Maribel Herrera Hernández

“…Los hombres mueren por cáncer de pulmón, próstata, colon, laringe y las mujeres por cáncer de pulmón, mama, colon, y útero. Las defunciones prematuras por cáncer en el 2010, representaron el 59,2 % del total de fallecidos por cáncer, de ellas el 47,9 % se produjeron en el grupo de 65 a 74 años de edad. …”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Potential threats to homeostasis might occur as early as during in utero life, potentially leaving a lasting mark on the developing organism. …”
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FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques by Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani

“…To test this hypothesis, we measured the transplacental transfer of leronlimab, an anti-CCR5 mAb, in clinical development for preventing HIV infections, using pregnant rhesus macaques to model in utero mAb transfer. We also generated a stabilized and FcRn-enhanced form of leronlimab, termed leronlimab-PLS. …”
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Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human by Fleur Zwanenburg, Thomas A. Bos, Arend D. J. Ten Harkel, Monique C. Haak, Nathan D. Hahurij, Robert E. Poelmann, Conny J. van Munsteren, Lambertus J. Wisse, Nico A. Blom, Marco C. DeRuiter, Monique R. M. Jongbloed

“…Results Murine cANS function did not definitively establish in utero as HRV parameters depicted no trend prior to birth. …”
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Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice by Xiao-ming Wang, Cai-ming Qin, Dou Li, Xin-ran Xu, Xiao-jing Pan, Hui Xue

“…Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero can result in osteogenic defect during palatogenesis, but the effects on other craniofacial bones and underlying mechanisms remain to be characterized. …”
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Mid-trimester resolution of marked dextroposition of the fetal heart preceding regression of extensive left fetal lung lesion consisting of hybrid congenital pulmonary airway malfo... by David M. Sherer, MD, Ida Dhanuka, MD, Kayla Schacher, MD, Hubert Rodriguez-Tejada, MD, Aleksandra Zigalo, RDMS, Mila Kheyman, RDMS, Harry Zinn, MD, Fancisca T. Velcek, MD, Mudar Dalloul, MD

“…Subsequent repeat ultrasound assessments confirmed gradual continued in-utero regression of the left lung lesion. The patient spontaneously delivered a vigorous infant neonate at 39 and 4/7 weeks’ gestation. …”
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Concordance of Prenatal Ultrasonography and Magnetic Resonance Imaging in the Classification of Corpus Callosum Dysplasia by Hui Peng, Xi Chen, Xuejin Zou, Yan Song, Chunlan Cheng, Jianli Zhang

“…Methods: A retrospective analysis was performed of fetuses with abnormal cavum septi pellucidi who had ultrasonography and MRI in utero in Sichuan Maternal and Child Health Hospital and Wenjiang District Maternal in China and Child Health Hospital from January 2018 to December 2023. …”
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Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood by Erin V. McGillick, Erin V. McGillick, Sandra Orgeig, Beth J. Allison, Kirsty L. Brain, Melanie R. Bertossa, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Youguo Niu, Nozomi Itani, Katie L. Skeffington, Christian Beck, Kimberly J. Botting-Lawford, Janna L. Morrison, Janna L. Morrison, Dino A. Giussani

“…Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress in utero to improve respiratory outcomes. We aimed to determine if the effects of chronic fetal hypoxia and antenatal antioxidant administration persist in the lung in early adulthood.MethodsChronically catheterised pregnant sheep were exposed to normoxia (N; n = 20) or hypoxia (H; n = 18; 10% O2) ± maternal daily i. v. saline (N = 11; H = 8) or Vitamin C (VC; NVC = 9; HVC = 10) from 105 to 138 days (term, ∼145 days). …”
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A novel minimally invasive neurosurgical cranial fixation device for improved accuracy of intraventricular catheter placement: an experimental animal study by Atai Daniel, Matan Coronel, Segev Peer, Ben Grinshpan, Soner Duru, Jose L. Peiro, James L. Leach, Elena Abellán, Carolyn M. Doerning, David Zarrouk, Francesco T. Mangano

“…The hydrocephalic animal model used for this study was created with in utero intracisternal injection of BioGlue in fetal lambs. …”
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Characterization of the gut microbiota and systemic inflammation in HIV-exposed uninfected infants from a resource-limited setting at 6 weeks of age by P. Munjoma, A. Mazhandu, J. Wyss, S. Ulrich Jordi, L. Katsidzira, B. Yilmaz, B. Misselwitz, K. Duri

“…Results: Among the 78 infants investigated, 35.9% were exposed to HIV in utero and during breastfeeding. At 6 weeks of age, 84.6% of the infants were exclusively breastfed, while 15.4% were mixed-fed with fluids and semi-solids. …”
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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Here, we report that disease-causing PDE12 variants in three unrelated families are associated with mitochondrial respiratory chain deficiencies and wide-ranging clinical presentations in utero and within the neonatal period, with muscle and brain involvement leading to marked cytochrome c oxidase (COX) deficiency in muscle and severe lactic acidosis. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…The finite pool of oocytes established in utero declines progressively throughout life, which is a natural process but may result in diminished ovarian reserve (DOR) in some women. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…Network analysis plot of downregulated genes in the females exposed to alcohol in utero showed a negative impact on T cell activation and regulation, T cell differentiation, decrease in CD8+ T cell number etc. …”
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Association of exposure to second-hand smoke during childhood with blood DNA methylation by Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Merid, Lucinda Calas, Paula de Prado-Bert, Rebecca Richmond, Vincent VW Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Grazuleviciene, Marianna Karachaliou, Gerard H. Koppelman, Erik Melén, Olena Gruzieva, Martine Vrijheid, Paul Yousefi, Janine F. Felix, Stephanie J. London, Mariona Bustamante

“…Notably, all except 2 CpGs (mapped to FIBCD1 and CTDSPL2) have previously been linked to either personal smoking habits or in utero exposure to smoking. The models restricted to non-smoking mothers provided similar results. …”
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