Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B1 by Donghua Su, Jing Peng, Jingjing Hao, Xi Wang, Peiqiang Yu, Shengli Li, Haitao Shi

“…Eighteen Saanen goats were assigned to 1 of 3 treatments and the AFB1 challenge lasted for 14 d. Results showed that the liver tissue was enlarged and the relative organ index of the liver was linearly increased with elevated AFB1 levels. …”
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…Human mesenchymal stem cells (MSCs) are good candidates for brain cell replacement strategies and have already been used as adjuvant treatments in neurological disorders. MSCs can be obtained from many different sources, and the present study compares the potential of neuronal transdifferentiation in MSCs from adult and neonatal sources (Wharton’s jelly (WhJ), dental pulp (DP), periodontal ligament (PDL), gingival tissue (GT), dermis (SK), placenta (PLAC), and umbilical cord blood (UCB)) with a protocol previously tested in bone marrow- (BM-) MSCs consisting of a cocktail of six small molecules: I-BET151, CHIR99021, forskolin, RepSox, Y-27632, and dbcAMP (ICFRYA). …”
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Alzheimer’s disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study by Juan Wang, Juan Wang, Jiamei Zhao, Xiaoling Chen, Xiaoling Chen, Bowen Yin, Xiaoli Li, Xiaoli Li, Ping Xie, Ping Xie

“…ObjectivesThe future emergence of disease-modifying treatments for dementia highlights the urgent need to identify reliable and easily accessible tools for diagnosing Alzheimer’s disease (AD). …”
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The Effect of FOXA3 Overexpression on Hepatocyte Differentiation and Liver Regeneration in a Fah cKO Mouse ModelSummary by Shao Li, Chupeng Ou, Jiajun Zhang, Min Zeng, Kangyan Liang, Qing Peng, Yi Gao

“…Partial hepatectomy and liver transplantation are effective treatments for liver diseases. This study investigated the effect of FOXA3 on cell differentiation in HepaRG cell lines under 2- and 3-dimensional culture conditions. …”
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Multisensory Stimulation in Rehabilitation of Dementia: A Systematic Review by Andrea Calderone, Angela Marra, Rosaria De Luca, Desirèe Latella, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

“…Its clinical value is rooted in its ability to offer a deep comprehension of how MSS can be successfully incorporated into rehabilitation treatments. <b>Methods</b>: Studies were identified from an online search of PubMed, EBSCOhost, Cochrane Library, Web of Science, Embase, and Scopus databases with a search time frame from 2014 to 2024. …”
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Integrating green manure and fertilizer reduction strategies to enhance soil carbon sequestration and crop yield: evidence from a two-season pot experiment by Jun Zhang, Jun Zhang, Jun Zhang, Wei He, Wei He, Wei He, Zheng Wei, Zheng Wei, Yifei Chen, Yifei Chen, Weichun Gao, Weichun Gao

“…The research employed a pot experiment conducted over two wheat-growing seasons (March 2021 to July 2022) at an experimental station in Baoji, China. Treatments included CK (control, no fertilizer), CF (conventional fertilizer), and reduced N-P fertilizer applications by 6% (RF6), 12% (RF12), 18% (RF18), and 24% (RF24). …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. …”
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DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner by Jianling Song, Yanxia Chen, Yan Chen, Minzi Qiu, Wenliu Xiang, Ben Ke, Xiangdong Fang

“…Background Chronic kidney disease (CKD) lacks effective treatments and renal fibrosis (RF) is one of CKD’s outcomes. …”
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Organomineral fertilizer based on wood ash in bean cultivation in acidic tropical soil by Rackel Danielly de Souza Alves, Edna Maria Bonfim-Silva, Tonny José Araújo da Silva, Jakeline Rosa de Oliveira, Jholian Maicon Ribeiro-Santos, Luana Aparecida Menegaz Meneghetti

“…Method: The experimental design used was randomized blocks, in a 4x3 factorial scheme, corresponding to three levels of base saturation (no liming - 0%, V = 30% and V = 60%), and four fertilization treatments: mineral, wood ash, organomineral and granulated organomineral, with four replications. …”
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Impact of quality of life on overall work productivity impairment and activity impairment of patients with systemic lupus erythematosus: the PEONY study by Yoshiya Tanaka, Shintaro Hirata, Shingo Nakayamada, Yusuke Miyazaki, Kazuyoshi Saito, Kunihiro Yamaoka, Shigeru Iwata, Yoshiyuki Yamaguchi, Keisuke Nakatsuka, Shunpei Kosaka, Katsuhide Kusaka, Toshiki Yabe-Wada, Masakazu Fujiwara, Yoshifumi Arita, Mitsuru Hoshino, Naoko Ozaki

“…Improving their quality of life and achieving social remission will require ongoing monitoring of PROs and tailoring treatments to optimise these outcomes.Trial registration number jRCT1030210647.…”
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Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Osteoarthritis is a leading cause of disability worldwide, challenging current treatments to limited cartilage self-healing capacity. …”
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Acute kidney injury is associated with liver-related outcomes in patients with hepatitis B virus infection: a retrospective cohort study by Jiao Liu, Ruixuan Chen, Shiyu Zhou, Zhixin Guo, Licong Su, Lisha Cao, Yanqin Li, Xiaodong Zhang, Fan Luo, Ruqi Xu, Qi Gao, Yuxin Lin, Xin Xu, Sheng Nie, the CRDS study Investigators

“…Our findings highlight the importance of monitoring AKI in patients with HBV infection for tailoring personalized treatments.…”
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Physio-Biochemical Indexes as Indicators of Cadmium Tolerance in <i>Brassica napus</i> L. Cultivars by Yu Qiu, Shuhe Wei, Jie Zhan, Brett H. Robinson, Lidia Skuza, Jianming Xue, Huiping Dai, Li Zhan, Ziyang Tang

“…A pot experiment was conducted in greenhouse to assess the differences in Cd accumulation and tolerance among three <i>Brassica napus</i> L. cultivars (‘Hanyou 2’, ‘Hanyou 3’, and ‘Hanyou 16’) under the treatments of CK (0.18 mg kg⁻¹ in soil), T1 (2.18 mg kg⁻¹ in soil), T2 (4.18 mg kg⁻¹ in soil), and T3 (8.18 mg kg⁻¹ in soil). …”
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Malva neglecta essential oil: A promising approach for bio-preserving mayonnaise and assessing variable correlations through principal component analysis and heat map by Amin Abbasi, Hedayat Hosseini, Hadi Pourjafar, Samaneh Moradi, Saeedeh Shojaee-Aliabadi

“…When MNEO was utilized at 5084 ppm, the oxidative stability of the specimens was also more effectively preserved at optimal levels (peroxide values of 1.76, 1.98, and 2.34 meq O2/kg of oil for TBHQ, 5084 ppm, and 2542 ppm treatments, respectively) (P < 0.05). Furthermore, it was noted that the specimens exposed to 5084 ppm MNEO had the highest sensory evaluation scores regarding aroma, hue, flavor, consistency, and general appeal (P < 0.05). …”
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Comprehensive Structural, Chemical, and Optical Characterization of Cu₂ZnSnS₄ Films on Kapton Using the Automated Successive Ionic Layer Adsorption and Reacti... by Perla J. Vázquez-González, Martha L. Paniagua-Chávez, Lizette A. Zebadua-Chavarria, Rafael Mota-Grajales, C. A. Meza-Avendaño, Enrique Campos-González, A. Escobosa-Echavarría, Yaoqiao Hu, Aldo E. Pérez-Ramos, Manuel-Matuz, Carlos A. Hernández-Gutiérrez

“…The investigation explored the effects of varying deposition cycles (40, 60, 70, and 80) and annealing treatments on the films. An X-ray diffraction (XRD) analysis demonstrated enhanced crystallinity and phase purity, particularly in films deposited with 70 cycles. …”
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Antibacterial Effect of Luma apiculata (DC.) Burret Extracts in Clinically Important Bacteria by Tiare Araya-Contreras, Rhonda Veas, Carlos A. Escobar, Pamela Machuca, Mauricio Bittner

“…Moreover, the resistance to antibiotics by these bacteria makes it necessary to find new treatments to fight them. Objective. To evaluate the antibacterial activity of Luma apiculata (DC.) …”
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Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients by Sarah A. Teele, MD, MSHPEd, Avihu Z. Gazit, MD, Craig Futterman, MD, William G. La Cava, PhD, David S. Cooper, MD, MPH, MBA, Steven M. Schwartz, MD, MS, Joshua W. Salvin, MD, MPH

“…Leveraging predictive analytics to guide timely patient care, including support for escalation or de-escalation of treatments, may improve care delivery for patients and clinicians.…”
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Association between the prognosis and comorbidity of active cancer in chronic thromboembolic pulmonary hypertension by Hiroyuki Fujii, Yu Taniguchi, Yuichi Tamura, Miki Sakamoto, Sachiyo Yoneda, Kenichi Yanaka, Noriaki Emoto, Ken-ichi Hirata, Hiromasa Otake

“…Results The baseline characteristics, hemodynamics, and treatments were similar between the groups. More than half of the cancer were diagnosed within two years before or after CTEPH diagnosis. …”
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Reducing the dietary starch:protein ratios in low-protein diets enhanced the growth performance of goslings from 1 to 28 days of age by Xucheng Zheng, Qian Lu, Chunhui Huang, Usman Nazir, Zhi Yang, Haiming Yang, Zhiyue Wang

“…The experimental design consisted of a 3 × 2 factorial array of treatments. Three protein levels (18%, 16%, 14%) and two starch: protein ratio (S: P ratio) types (standard, reduced) were formulated. …”
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The role of Latin America medicinal plants in wound healing by Mariana Sánchez-Ramos, Andrea Ruiz-Betancourt, Stephany Abigail Tadeo-Cuenca, Angélica Román-Guerrero, María Crystal Columba-Palomares, Araceli Guerrero-Alonso, Antonio Bernabé-Antonio, Deyanira Ojeda-Ramírez, Francisco Cruz-Sosa

“…Additionally, 32 natural compounds with diverse structural nature were found, whose effects have been evaluated in in vivo and in vitro models, which are essential for studying the pathogenesis of the tissue repair mechanism, detecting new biomarkers, and evaluate new treatments. Currently, several models are used to study the wound healing process, including in silico, in vitro, and in vivo models. …”
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