QSPR/QSAR study of antiviral drugs modeled as multigraphs by using TI’s and MLR method to treat COVID-19 disease by Ugasini Preetha P, M. Suresh, Fikadu Tesgera Tolasa, Ebenezer Bonyah

“…Researchers are actively exploring antiviral treatments to assess their efficacy against emerging virus variants. …”
Get full text

Influence of No-Tillage on Soil Organic Carbon, Total Soil Nitrogen, and Winter Wheat (Triticum aestivum L.) Grain Yield by Peter Omara, Lawrence Aula, Elizabeth M. Eickhoff, Jagmandeep S. Dhillon, Tyler Lynch, Gwendolyn B. Wehmeyer, William Raun

“…In each tillage system, treatments included nitrogen (N) rates at E222 (0, 45, 90, and 135 kg·N·ha−1) and E502 (0, 22.5, 45, 67, 90, and 112 kg·N·ha−1). …”
Get full text

Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammatory Bowel Disease by Panu Wetwittayakhlang, Farah Albader, Petra A Golovics, Gustavo Drügg Hahn, Talat Bessissow, Alain Bitton, Waqqas Afif, Gary Wild, Peter L Lakatos

“…Demographics, comorbidities, IBD (type, treatments, pre- and post-COVID-19 clinical activity, biomarkers, and endoscopic activity), and COVID-19-related outcomes (pneumonia, hospitalization, death, and flare of IBD disease) were analyzed. …”
Get full text

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing by Daisi Zheng, Xiaolong Li, Peicheng Wang, Qingmiao Zhu, Zhiyan Huang, Ting Zhao

“…The mechanisms underlying fatigue in these disorders remain unclear, and there are no standardized treatments. This study aims to explore shared mechanisms and predict potential therapeutic drugs for fatigue in SLE and ME/CFS.MethodsGenes associated with SLE and ME/CFS were collected from disease target and clinical sample databases to identify overlapping genes. …”
Get full text

Growth response of tissue culture-derived bamboo (Bambusa tulda Roxb.) Plantlets to sources and levels of inorganic nitrogen by Catherine C. Arradaza, Antoneth A. Modina, Arsenio D. Ramos, Rafonselle M. Moreno

“…The effects of the treatments on the performance of the bamboo plantlets were evaluated by gathering growth parameters such as height, number of leaves and culms and leaf size, and dry weights of leaf, stem, root, and total biomass weight. …”
Get full text

Black Soldier Fly (<I>Hermetia illucens</I>) Oil Inclusion and its Effects on Growth Performances in Common Carp (<I>Cyprinus carpio</I>) by Vivi Endar Herawati, Heni Tri Jayanti, Tita Elfitasari, Sapto Purnomo Putro, Seto Windarto

“…This study used a complete randomized design (CRD) with four treatments and three replicates: A, B, C, and D with the addition of maggot oil doses of 0%, 10%, 15%, and 20%, respectively. …”
Get full text

Some utilisation options for cattle dung as soil amendment and their effects in coarse-textured Ultisols and maize growth by Solange Ndzeshala, Sunday Obalum, Charles Igwe

“…Soil pH, Mg2+ and base saturation together caused 93% of treatments’ effects on dry matter.Conclusion Converting CD to BC or supplementing it with urea (CDU) in coarse-textured tropical soils could have prolonged liming and/or biomass productivity-enhancing effects as PD.…”
Get full text

Effects of Dietary Protein-to-Energy Ratios on Growth, Immune Response, Antioxidative Capacity, Liver and Intestinal Histology, and Growth-Related Gene Expression in Hybrid Yellow... by Sehrish Taj, Quan Han, Xiaoyi Wu, Haoran Yin, Lixia Tian, Huijun Yang, Yongjian Liu, Junwa Huang

“…Seven hundred and twenty healthy fish (17.15±0.02 g) were randomly dispersed into 24 rectangular fiberglass tanks with 8 treatments in triplicate groups. The fish fed a P/E ratio of 95 mg/kcal demonstrated the best growth and feed utilization. …”
Get full text

Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes by Arthur Monjot, Jérémy Rousseau, Lucie Bittner, Cécile Lepère

“…All these protein families could offer valuable insights for developing antiparasitic treatments in health and economic contexts. Video Abstract…”
Get full text

Correlation Between Objective Habit Metrics and Objective Medication Adherence: Retrospective Study of 15,818 Participants From Clinical Studies by Antoine Pironet, L Alison Phillips, Bernard Vrijens

“…These participants took part in 108 clinical studies mainly focused on treatments for hypertension (n=4737, 30%) and osteoporosis (n=3353, 21%). …”
Get full text

Replacement of fishmeal with Quinoa Husk (Chenopodium quinoa) for mitigating multiple stresses in Pangasianodon Hypophthalmus by Neeraj Kumar, Paritosh Kumar, Aliza Pradhan, Dilip Kumar Singh, Tarkeshwar Kumar, Jagadish Rane, Kotha Sammi Reddy

“…The study was designed with 12 treatments as control, stressors group (concurrent exposed to ammonia, arsenic and high temperature stress, NH3+As+T), group fed with QH at 15, 20, 25, 30 and 35% without and with stressors (NH3+As+T) in Pangasianodon hypophthalmus for 105 days. …”
Get full text

Management of acute myocardial infarction in chronic kidney disease in Germany: an observational study by Victor Walendy, Andreas Stang, Matthias Girndt

“…Furthermore, we calculated log-binominal regression models adjusting for sex, CKD, RRT, comorbidities, and place of residence to estimate adjusted relative-risks (aRR) for receiving treatments of interest in AMI, such as PCI or CABG. …”
Get full text

Evaluation of high-value bioproducts production by marine endophytic fungus Arthrinium sp. FAKSA 10 under solid state fermentation using agro-industrial wastes by Mohammad J. Alsarraf, Fuad Ameen, Abdullah Alfalih, Zirak Sajjad

“…Background: To address public health challenges, there is increasing interest in bioactive metabolites from unconventional sources for targeted cancer and viral treatments with minimal side effects. Endophytic fungi are promising for these therapies. …”
Get full text

Biochar Quality During Slow Pyrolysis from Oil Palm Empty Fruit Bunches and Its Application as Soil Ameliorant by Amsar Maulana, Mimien Harianti, Salma Athiyya, Teguh Budi Prasetyo, Moli Monikasari, Irwan Darfis, Dewi Rezki, Herviyanti Herviyanti

“…The first experiment assessed the effect of slow pyrolysis temperature on the quality of biochar derived from OPEFB, with treatments set at four temperatures (150, 200, 250, and 300 °C) levels. …”
Get full text

The Importance of Platelet-Derived Growth Factors as Markers of Survival and Severity of COVID-19 in Patients Undergoing Monthly Follow-Up by Elżbieta Cecerska-Heryć, Dominika Nieszpór, Natalia Serwin, Ewa Pius Sadowska, Marta Gliźniewicz, Bartłomiej Grygorcewicz, Karol Serwin, Anna Michalczyk, Marta Budkowska, Małgorzata Goszka, Aleksandra Polikowska, Radosław Birger, Bogusław Machaliński, Barbara Dołęgowska

“…In the future, GF may serve as a predictor of disease severity and the development of new treatments for COVID-19. In later studies, the focus should be on finding the relationship of COVID-19 pathomechanism with all the parameters to understand the processes that occur in the body during SARS-CoV-2 virus infection.…”
Get full text

Effects of drugs on kinetic values of cytokines, adenosine deaminase and 13,14-dihydro-15-keto-prostaglandin f&lt;sub&gt;2&#945;&lt;/sub&gt; in endotoxemia: a different approach by Feray Altan, Muammer Elmas, Ayse Er, Kamil Uney, Gul Cetin, Bunyamin Tras, Enver Yazar

“…The six other groups received the following drugs: ENR, FM, low-dose DEX, high-dose DEX, ENR + FM + low-dose DEX and ENR + FM + high-dose DEX. After the treatments, blood samples were collected at 0, 1, 2, 4, 6, 8, 12, 24, and 48 hours. …”
Get full text

Optimal aspiration pressure of suction pump for oocyte retrieval in infertile patients undergoing in vitro fertilization. by Sung Woo Kim, Hye Yun Kim, Ji Yeon Han, Hoon Kim, Seung-Yup Ku

“…These findings provide valuable insights for clinical decision-making in infertility treatments, suggesting that 150mmHg may be a more effective pressure for oocyte retrieval in in vitro fertilization and embryo transfer.…”
Get full text

Development of ¹¹¹In-Labeled Monoclonal Antibodies Targeting SFTSV Structural Proteins for Molecular Imaging of SFTS Infectious Diseases by SPECT by Takeshi Fuchigami, Mya Myat Ngwe Tun, Yusuke Tanahara, Kodai Nishi, Sakura Yoshida, Kazuma Ogawa, Morio Nakayama, Daisuke Hayasaka

“…No effective vaccines or treatments are currently available for severe fever with thrombocytopenia syndrome (SFTS), a fatal tick-borne infectious disease caused by the SFTS virus (SFTSV). …”
Get full text

Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP): Protocol for a Phase 2 Feasibility Randomised Trial [version 1; peer review: 1 approved, 2 approved with rese... by Orlaith Doherty, Conor White, Nanna Brix Finnerup, Eimear Smith, Mark Pollock, Nathan Kirwan, Olive Lennon, Catherine Blake

“…Pharmacotherapies are commonly recommended for NP management in SCI, although severe pain often remains refractory to these treatments in many sufferers. Furthermore, poor medication adherence exists, stemming from unacceptable side-effects and fear of dependency. …”
Get full text

Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…These isogenic PSC lines will be valuable tools for establishing <i>OPA1</i>-DOA disease models in vitro and developing treatments for mitochondrial deficiency associated neurodegeneration.…”
Get full text