Standardization of the Agar Plate Method for Bacteriophage Production by Su Jin Jo, Young Min Lee, Kevin Cho, Seon Young Park, Hyemin Kwon, Sib Sankar Giri, Sung Bin Lee, Won Joon Jung, Jae Hong Park, Mae Hyun Hwang, Da Sol Park, Eun Jae Park, Sang Wha Kim, Jin Woo Jun, Sang Guen Kim, Ji Hyung Kim, Se Chang Park

“…The growing threat of antimicrobial resistance (AMR), exacerbated by the COVID-19 pandemic, highlights the urgent need for alternative treatments such as bacteriophage (phage) therapy. Phage therapy offers a targeted approach to combat bacterial infections, particularly those resistant to conventional antibiotics. …”
Get full text

Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…There are no disease-modifying or preventative treatments for this uniformly fatal disorder. Recent studies demonstrate prominent white matter atrophy and microstructural alterations in disease-vulnerable brain regions of SCA3 patients and mouse models. …”
Get full text

The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review by Yajia Cheng, Yue Shang, Shuqin Zhang, Saijun Fan

“…The diverse radiation types in medical treatments and the natural environment elicit complex biological effects on both cancerous and non-cancerous tissues. …”
Get full text

Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…Precise genetic diagnosis in GKD promises to improve patient outcomes, provide access to targeted treatments, and reduce the disease burden for individuals, families, and healthcare systems. …”
Get full text

Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

“…In both cases, often no explanation for reproductive failure can be found and although promising add-on treatments have been introduced, therapeutic options are frequently limited to supportive care. …”
Get full text

Monitoring the Spread of Multidrug-Resistant <i>Escherichia coli</i> Throughout the Broiler Production Cycle by Victor Dellevedove Cruz, Danilo Henrique Rabaçal Alves, Jamile Kellen de Souza, Maísa Fabiana Menck-Costa, Bruno Henrique Dias de Oliva, Ana Angelita Sampaio Baptista, Alexandre Oba, Fabrizio Matté, Kácio Emílio Borges Baierle, Sérgio Paulo Dejato da Rocha, Kelly Cristina Tagliari de Brito, Benito Guimarães de Brito, Gerson Nakazato, Marcio Costa, Renata Katsuko Takayama Kobayashi

“…The monitoring of antimicrobial virulence and resistance genes are tools that have come to assist the breeding of these animals, directing possible treatments as already used in human medicine and collecting data to demonstrate possible dissemination of multidrug-resistant strains that may cause damage to industry and public health. …”
Get full text

Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study by Kazuyuki Hirooka, Eri Nitta, Yoshiaki Kiuchi, Masaki Tanito, Shunsuke Nakakura, Tetsuya Baba, Hideaki Okumichi, Aisyah Muhlisah, Ariyanie Nurtania, Hiromitsu Onoe, Yotaro Matsuoka

“…Background To investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.Methods This prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent trabeculectomy or trabeculectomy combined with cataract surgery followed by 3-month postoperative ripasudil treatments. After randomly allocating patients to ripasudil—ROCK inhibitor (ripasudil) or without ripasudil (non-ripasudil) groups. …”
Get full text

Induced Defense in Ryegrass–Epichloë Symbiosis Against <i>Listronotus bonariensis</i>: Impact on Peramine Levels and Pest Performance by Manuel Chacón-Fuentes, Gunnary León-Finalé, Marcelo Lizama, Gastón Gutiérrez-Gamboa, Daniel Martínez-Cisterna, Andrés Quiroz, Leonardo Bardehle

“…Argentine stem weevil adults and larvae were placed on ryegrass leaves and stems to assess feeding. Two treatments were used: endophyte-free plants and endophyte-colonized plants. …”
Get full text

Comparing rumen fluid collection methods on fermentation profile and microbial population in lactating dairy cows by N. Pathak, H. Guan, P. Fan, H. Sultana, K. Arriola, A. Oyebade, C. Nino de Guzman, M. Malekkhahi, K.C. Jeong, D. Vyas

“…The experimental period was 28 d and rumen fluid was collected 4 h after feeding on d 22 and 26 of each experimental period. Treatments were rumen fluid collected from the ST or RC. …”
Get full text

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Moreover, PFNA exhibited sublethal effects by curtailing feeding and raising mortality rates; in 100 mg/L and 500 mg/L treatments, cumulative mortality reached 30.70 % and 53.60 %, respectively, by day 15. …”
Get full text

Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Although recent advances have improved the overall prognosis, they have not had an important impact on survival of patients with MPM, such that more effective treatments are needed. Some species of marine snails have been demonstrated to be potential sources of novel anticancer molecules. …”
Get full text

Identification and functional analysis of Wall-Associated Kinase genes in Nicotiana tabacum by Ling Li, Linggai Cao, Jintao Li, Zhiqiang Zhang, Zhiqiang Zhang, Jie Liu, Zhongying Ren, Jie Zhang, Rengang Wang, Yangfan Miao, Shizhou Yu, Wei Li, Wei Li

“…Expression profiling under NaCl, PEG, and ABA treatments suggested that certain NtWAK genes may play key roles in modulating responses to abiotic stress. …”
Get full text

An Acceleration of Cendana (Santalum album) Growth Using Addition of Essential Macro Nutrients n on Three Types of Soil by Eny Faridah, Haryono Supriyo, M Gunawan Wibisono, Kristinawati Kristinawati, Dwi Afiani, Dian Hartanti

“…Research was applied using Completely Randomized Design (CRD) with treatments of 3 soil types (Grumusol (Vertisol), Mediterran (Alfisol) and Regosol (Entisol)), 3 fertilizer types (biosulfo, biofosfo, and NPK), and 5 fertilizer dosages (0, 2.5, 5, 7.5 and 10 g) with 5 replications for each experiment unit. …”
Get full text

Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

“…BackgroundPostherpetic neuralgia (PHN) is a chronic neuropathic pain condition in elderly patients following herpes zoster infection. Conventional treatments often have inconsistent efficacy and significant side effects. …”
Get full text

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…In vivo efficacy was assessed using three HER2-positive tumor models, with dose-dependent tumor growth inhibition compared to established treatments. Pharmacokinetic studies were conducted in cynomolgus monkeys across a dosing range (3–30 mg/kg) to compare clearance and stability with Kadcyla and Enhertu. …”
Get full text

Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice by Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue

“…These data indicated that diet control and/or swimming ameliorate cognitive deficits through the inhibitory effect of neuroinflammation via SIRT1-mediated pathways, strongly suggesting that swimming and/or diet control could be potentially effective nonpharmacological treatments for cognitive impairment.…”
Get full text

HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib by Yingai Zhang, Yuting Zhang, Shuai Zhou, Mujeeb Ur Rehman, Fankai Lin, Jianquan Zhang, Hailong Zhou

“…Abstract Background Hepatocellular carcinoma (HCC) has a poor prognosis, partly due to resistance to treatments like sorafenib. The 5-hydroxytryptamine receptor 1D (HTR1D) is involved in cancer progression through the PI3K/Akt pathway, but its role in HCC is not well understood. …”
Get full text

Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma by Qianru Li, Qianru Li, Heli Li

“…The integration of bioinformatics and machine learning provides a robust framework for enhancing prognostic evaluation in melanoma patients and offers new avenues for the development of treatments, particularly for those resistant to current immunotherapies.…”
Get full text

Awareness and perception of prevention and management options of sexually transmitted infections among students at secondary school in Rivers State, Nigeria by Florence Mandah, Oluebubechukwu Udi, Pamela Thompsom-Abiye, Basil Ogbu

“…Introduction Investments in programs to increase sexual health awareness among young people is ongoing; however, they continue to be exposed to sexually transmitted infections (STIs) and remain vulnerable to risky sexual practices, such as multiple sexual partners and unprotected sexual intercourses, predisposing them to STIs and subsequent treatments from informal and formal health providers. …”
Get full text

Nodulation, Growth, and Yield of Soybean (Glycine max L. Merrill) as Affected by Bio-, Organic, and Inorganic NPSB Fertilizers, and Lime in Assosa Zone, Western Ethiopia by Abiyot Abeje, Getachew Alemayehu, Tesfaye Feyisa

“…Results of the experiment showed that effective nodules, leaf area index, grain yield, bulk density, pH, total nitrogen, available phosphorus, organic carbon, and cation exchange capacity were highly (P<0.01) affected by the interaction of bio-, organic, and inorganic fertilizers and lime at both locations and years. Across all treatments, the grain yield of soybean was increased in the second year, while it was lowest in the first year at both locations. …”
Get full text