The role of cyclooxygenase-2 (COX-2) and inflammatory markers in the progress of Alport syndrome in Egyptian children by Moushira Zaki, Hisham A. Orban, Mohamed A. Shahba, Rehab S. I. Moustafa, Ahmed Adel, Fatina I. Fadel, Abeer Selim, Hala T. El-Bassyouni, Eman R. Youness

“…This may highlight and speculate an innovative strategy for targeting the creation of safe and efficient anti-inflammatory treatments to inhibit disease progression in Alport syndrome.…”
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Effect of Planting Density on the Agronomic Performance and Fruit Quality of Three Pineapple Cultivars (Ananas comosus L. Merr.) by Juan C. Neri, Jegnes Benjamín Meléndez Mori, Nuri Carito Vilca Valqui, Eyner Huaman Huaman, Roicer Collazos Silva, Manuel Oliva

“…The diameter (11.77–13.29 cm) and weight of the fruit without a crown (1.48–1.85 kg) were not affected by the treatments; in contrast, the length and weight of the fruit with a crown did exhibit significant variations, highlighting the “Smooth Cayenne” cultivar and “Santa Rosa” ecotype at a density of 55500 plants ha−1, respectively. …”
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Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Acti... by Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

“…However, to date, no effective treatments for hair graying have been developed, and the effect of SHED-CM on hair graying remains unknown. …”
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Human in vivo talocrural contributions to ankle joint complex kinematics during walking, running, and hopping by Anja-Verena Behling, Lauren Welte, Michael J. Rainbow, Luke Kelly

“…In addition, the large out-of-sagittal plane movements and inter-subject variability in talus and calcaneus motion may further emphasize the need for personalised models to investigate treatments for ankle pathologies.…”
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A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders by Marta Di Forti, Benjamin W. Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B.M. Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P. Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-Zimmerman, Tim Meynen, Diego Quattrone, Robin M. Murray

“…Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. …”
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Diagnosis of Water-Influx Locations of Horizontal Well Subject to Bottom-Water Drive through Well-Testing Analysis by Jiazheng Qin, Shiqing Cheng, Youwei He, Dingyi Li, Le Luo, Xinzhe Shen, Haiyang Yu

“…Additionally, relevant measures can be conducted to enhance oil production, such as water controlling for water-breakthrough segments and stimulation treatments for nonproducing locations.…”
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Analysis of microstructural evolution and mechanical properties of FGH101 powder superalloy and IN718 deformed superalloy via inertia friction welding by Jun Zhou, Jun Zhou, Yongqiang Zhang, Yongqiang Zhang, Yongqiang Zhang, Feng Qin, Feng Qin, Xuelong Zhang, Xuelong Zhang, Hao Wang, Hao Wang, Ze Liu, Ze Liu, Wenhan Zhang, Wenhan Zhang, Caiyan Huang, Caiyan Huang, Chunbo Zhang, Chunbo Zhang

“…Microhardness analysis revealed higher hardness at the weld interface, followed by a sharp decline near the Heat Affected Zone (HAZ) on the IN718 side due to phase re-dissolution, while FGH101 showed quicker recovery. Post-weld aging treatments enhanced hardness and strength through γ′ and δ phase precipitation in FGH101 and γ″ phases in IN718. …”
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Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent... by Shunsuke Suzuki, Shintaro Shiba, Hiroki Tanaka, Masashi Yamanaka, Kazuki Matsumoto, Koichi Tokuuye, Motoko Omura

“…The difference in LAR between the three treatments for each organ and the number needed to treat (NNT), as an indicator of the number of cases required to achieve the effect of suppressing the occurrence of secondary cancers, was calculated and evaluated. …”
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Exogenous Application of Thidiazuron, Carbaryl, Ethephon, and Lime Sulphur Promotes Flower Abscission and Suppresses Tea Pests in the Tea Plant <i>Camellia sinensis</i> (L.) O. Kun... by Meina Jin, Xiaoyue Lun, Ruirui Zhang, Yu Zhang, Xiangzhi Zhang, Feiyu Guan, Liping Wang, Yiheng Ying, Zhengqun Zhang, Xiuxiu Xu

“…However, no significant differences in frost damage were observed across treatments. Overall, exogenous application of the chemicals, particularly thidiazuron, effectively reduced flower production, altered key biochemical components, controlled tea pests, and ultimately enhanced tea productivity.…”
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Reproductive efficiency of ewe lambs kept on tropical pastures under different feeding systems by L.M. Higano, C.C.B.F. Ítavo, L.C.V. Ítavo, G.S. Difante, G.K.A. Melo, P.C.G. Silva, K.L.S. Monteiro, E.S.M. Soares, T.F.F.S. Arco, P.B. Andrade, A.A.S. Miguel, F.G.G. Oliveira, E.L.M. Ribeiro, A.L.C. Gurgel

“…The lambs were distributed in two treatments with protein-energy supplementation at levels 1.6 and 2.4% of body weight and reared on Brachiaria brizantha cv. …”
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Interspecific Variations in Interplant Communication and Ecological Characteristics in Trees by Akira Yamawo, Tomika Hagiwara, Satomi Yoshida, Misuzu Ohno, Riku Nakajima, Yusuke Mori, Tamayo Hayashi, Hiroki Yamagishi, Kaori Shiojiri

“…However, LPD trees did not differ in leaf damage between treatments. These results are partially supported by plant hormone analysis. …”
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Pulmonary fibrosis in patients with autoimmune pulmonary alveolar proteinosis: a retrospective nationwide cohort study by Yoann Guirriec, David Luque-Paz, Gontran Bernard, Axelle Mabo, Mallorie Kerjouan, Cédric Ménard, Delphine Monnier, Hilario Nunes, Yurdagül Uzunhan, Martine Reynaud-Gaubert, Julien Bermudez, Raphaël Borie, Bruno Crestani, Julie Traclet, Lidwine Wémeau-Stervinou, Cécile Chenivesse, Emmanuel Gomez, Grégoire Prévot, Arnaud Bourdin, Benjamin Bondue, Anne Bergeron, Vincent Cottin, Mathieu Lederlin, Stéphane Jouneau

“…Dust exposure was associated with pulmonary fibrosis occurrence (OR 4.3; p=0.038). aPAP patients treated with whole-lung lavage, rituximab or granulocyte–monocyte colony-stimulating factor therapy did not have more fibrotic evolution than patients who did not receive these treatments (n=25 out of 45, 57% versus n=10 out of 16, 62%; p=0.69). …”
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Validation of a Questionnaire on COVID-19 Knowledge and Attitude for Dental Patients by Mohammad Reza Khami, Mahsa Karimi, Morenike Oluwatoyin Folayan, Ahmad Reza Shamshiri, Prathip Phantumvanit, Armando E Soto-Rojas, Seyed Hossein Bassir, Heikki Murtomaa

“…The questionnaire consisted of six sections covering background information, knowledge of emergency dental treatments, transmission routes of disease, required preparation, source of information, and attitude. …”
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Effect of Oral Administration with Lactobacillus plantarum CAM6 Strain on Sows during Gestation-Lactation and the Derived Impact on Their Progeny Performance by César Betancur, Yordan Martínez, Guillermo Tellez-Isaias, Rogel Castillo, Xinghua Ding

“…To evaluate the biological response of the sows and their offspring with oral administration of Lactobacillus plantarum CAM6 in breeding sows, a total of 20 Pietrain breeding sows with three farrowings and their descendants were used, randomly divided into two groups of 10 sows each. Treatments included a basal diet (T0) and basal diet +10 mL biological agent containing 109 CFU/mL L. plantarum CAM6 (T1). …”
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Enhanced wheat yield and flag leaf physiology in saline-alkali soils using modified straw water-retaining agent by Min Yang, Cexun Ji, Kui Chao, Pengfei Zhu, Xiaoqing Yuan, Zenghui Hao, Xiulin Wang, Yan Shi

“…Two-year experiment was conducted, and five treatments were set up: CK (no water-retaining agent), T1 (18 kg·ha−1 modified straw water-retaining agent), T2 (36 kg·ha−1 modified straw water-retaining agent), T3 (54 kg·ha−1 modified straw water-retaining agent), T4 (36 kg·ha−1 commercial water-retaining agent). …”
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Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to comp... by Wenjing Zhang, Lin Xia, Zhilong Yuan, Mengdan Liu, Yang Jiao, Zhuo Wang

“…An explanation for these different efficacies in clinical treatments is still limited. The analysis method was developed and validated to simultaneously quantify nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine (NHC) in human plasma and bronchoalveolar lavage fluid (BALF) by electrospray ionization mass spectrometry.Our method was validated over a linear range of 30–10000 ng/mL for both matrices, with precision and accuracy within 15 % across four concentrations. …”
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Biotransformation of organic wastes through composting using Trichoderma harzianum and its effects on cucumber ( Cucumis sativus L.) yield by Adeniyi Soretire, Cynthia A Ezema, Chukwuebuka E Awaogu, Chukwuagozie C Okafor, Abasiama S Umoren, Nurudeen O Adeyemi

“…The present study was aimed to assess the effect of Trichoderma harzianum on the bioconversion of different solid organic wastes into compost and its application on cucumber. Method The treatments were 3 levels of T. harzianum inoculum (0, 5 and 10 ml) and 4 types of solid organic wastes (maize-cob, groundnut-pods, sawdust and their mixture) and soil. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…This discovery provides a new avenue for the development of therapeutic treatments for HF and a new target for drug development.…”
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Soil Inversion with Subsoiling Increases Cotton Yield Through Improving Soil Properties and Root Growth by Pengcheng Li, Shulin Wang, Weina Feng, Helin Dong, Cangsong Zheng, Miao Sun, Jingjing Shao, Zhenggui Zhang, Zhanlei Pan, Jian Wang, Guilan Sun, Junhong Li, Yaopeng Zhang, Wenqi Zhao, Menghua Zhai, Zhanbiao Wang

“…Here, a field experiment was set from 2015 to 2017 with three treatments: CK, 15 cm rotary tillage; T1, replace the top 20 cm soil layer with the 20–40 cm soil layer and loosen the 40–55 cm soil layer; T2, replace the top 20 cm soil layer with the 20–40 cm soil layer and loosen the 40–70 cm soil layer. …”
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Comparison of clinical variables and outcome of 2 natural equine herpesvirus myeloencephalopathy outbreaks induced by equine herpesvirus‐1 A2254/N752 strain in sport horses by María de laCuesta‐Torrado, Ana Velloso Alvarez, José Miguel Cárdenas‐Rebollo, Patricia Neira‐Egea, Valentina Vitale, Juan Cuervo‐Arango

“…Results No risk factors associated with EHM development showed significant differences between the outbreaks; both outbreaks were caused by A2254/N752 strains. Treatments administered for EHM were not significantly different, whereas the duration was longer in 2021 for flunixin meglumine (P = .01) and dimethyl sulfoxide (P < .001). …”
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