L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson’s Disease: A Randomised Study by Fabrizio Stocchi, Laura Vacca, Paola Grassini, Stephen Pawsey, Holly Whale, Stefano Marconi, Margherita Torti

“…Carbidopa exposure and interpatient variability was lower when V1512 or L-dopa/carbidopa was given in combination with entacapone. Both treatments were well tolerated. Conclusions. V1512 provides a more reliable L-dopa pharmacokinetic profile versus standard-release L-dopa/carbidopa, with less drug accumulation and less variability. …”
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Population genetics of Glossina palpalis gambiensis in the sleeping sickness focus of Boffa (Guinea) before and after eight years of vector control: no effect of control despite a... by Kagbadouno, Moise S, Séré, Modou, Ségard, Adeline, Camara, Abdoulaye Dansy, Camara, Mamadou, Bucheton, Bruno, Bart, Jean-Mathieu, Courtin, Fabrice, De Meeûs, Thierry, Ravel, Sophie

“…We thus recommend the pursuit of vector control measures with the same strategy, through the joint effect of VCC and medical surveys and treatments, in order to protect human populations from HAT infections until the disease can be considered as entirely eradicated from the focus.…”
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Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect by Coralia Cuadrado, Alex Mantilla, Luis Hidalgo, Diego Punina

“…Conclusions: The study demonstrates that both IONs-MWCNTs-Pc and IONs-GO-Pc nanocomposites show promise as alternative treatments for infections caused by antibiotic-resistant bacteria, with the GO-based composite showing higher photodynamic therapy efficacy. …”
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Effect of integrative NPK soil and foliar nutrition on winter wheat (Triticum aestivum L.) productivity in irrigated arid lands by Komolitdin Sultonov, Guzal Kholmurodova, Jamoliddin Eshonkulov, Kholik Allanov, Obidjon Sindarov, Kholmurod Khayitov, Jamila Khaitbaeva, Shavkat Salomov, Sabirjan Isaev, Altingul Djumanazarova, Risolatxon Imyaminova, Nodirakhan Jurayeva, Mavluda Karimova, Lobar Khayrullaeva, Nodirakhon Yakubjonova, Normat Durdiev, Rano Yuldasheva, Botir Khaitov

“…The main plots consisted of three chemical fertilization treatments at the following rates: N150P105K75, N180P125K90, and N210P145K105. …”
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Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised contro... by Emma Stevenson, Amy Jennings, Anne Marie Minihane, Rachel Gillings, Alpar Lazar, M Hornberger, Saber Sami, Latife Esgunoglu, Marrium Liaquat, Adrian Leddy, Jon Brooks, William Penny

“…A linear mixed model and/or paired analysis will be used to compare the effects of treatments over time.Ethics and dissemination The study has received a favourable ethics opinion from the National Health Service London Queen Square Research Ethics Committee (22/LO/0796). …”
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Executive function deficit in patients with long COVID syndrome: A systematic review by Siti Maisarah Nasir, Noorazrul Yahya, Kah Hui Yap, Hanani Abdul Manan

“…This insight has the potential to improve future treatments and interventions.…”
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Silicon-mediated modulation of maize growth, metabolic responses, and antioxidant mechanisms under saline conditions by Muhammad Saad Ullah, Athar Mahmood, Hussam F. Najeeb Alawadi, Mahmoud F. Seleiman, Bilal Ahmad Khan, Muhammad Mansoor Javaid, Abdul Wahid, Fnu Abdullah, Daniel O. Wasonga

“…Methods The maize was cultivated in sand-filled pots, incorporating varied silicon and salt stress (NaCl) treatments. Silicon was applied at 0, 2, 4, 6, and 8 mM, and salt stress was induced using 0, 60 and120 mM concentrations. …”
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Nitrogen Efficiency and Nutrient Absorption by a Sorghum-Oats Forage Succession by Rasiel Restelatto, Paulo Sergio Pavinato, Laércio Ricardo Sartor, Suelen Maria Einsfeld, Fernanda Paula Baldicera

“…The experiment was carried out at Federal Technological University of Paraná (UTFPR), Dois Vizinhos, Paraná, Brazil, in Rhodic Hapludox soil. Treatments included 0, 37.5, 75, 150, 225, 300, and 375 kg N ha−1 applied to sorghum in the summer seasons of 2010/2011 and 2011/2012, intercalated by, respectively, 0, 40, 80, 120, 160, 200, and 240 kg N ha−1 applied to black oat in the winter/2011. …”
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Exploring the general practitioners’ perception of the inter-professional care of rheumatoid arthritis patients (GEPRA—II): a qualitative interview study by Anne-Laure Yailian, Audrey Janoly-Dumenil, Emmanuelle Vignot, Aurélie Fontana, Charline Estublier, Cyrille Confavreux, Roland Chapurlat, Claude Dussart, Humbert de Freminville

“…They perceived their patients to be adherent to their treatments, although they frequently identified reasons for non-adherence. …”
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The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol by Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, Sarah Brode, Theodore K. Marras, Ryan Cooper, Maeve Smith, Julie Jarand

“…Participants will undergo annual follow-ups to gather longitudinal information regarding outcomes, treatments and changes in QoL. The inclusion criteria are a diagnosis of bronchiectasis by clinical history and computed tomography and/or pulmonary NTM infection as defined by American Thoracic Society/Infectious Diseases Society of America guidelines. …”
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Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets by Wenlu Zhu, Huilin Zhang, Haitao Pan, Hao Zeng, Wenjun Wang, Yunfeng Liu, Zirui Wang, Qiubai Zhou, Chuanqi Yu

“…In this study, Monopterus albus were randomly grouped into treatments: a normal diet (20 % carbohydrate, NC), a high carbohydrate diet (32 % carbohydrate, HC), and high carbohydrate diets supplemented with 0.5 % SA (LA). …”
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Light and dark biofilm adaptation impacts larval settlement in diverse coral species by Paul A. O’Brien, Sara C. Bell, Laura Rix, Abigail C. Turnlund, Shannon R. Kjeldsen, Nicole S. Webster, Andrew P. Negri, Muhammad A. Abdul Wahab, Inka Vanwonterghem

“…Here, we assessed larval settlement responses in five non-acroporid broadcast-spawning coral species in the families Merulinidae, Lobophyllidae and Poritidae to biofilms developed in aquaria for either one or two months under light and dark treatments. Biofilms were characterised using 16S rRNA gene sequencing to identify the taxa associated with settlement induction and/or inhibition. …”
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CD7‐targeting pro‐apoptotic extracellular vesicles: A novel approach for T‐cell haematological malignancy therapy by Bei Zhang, Jianqiang Chen, Jiming Chen, Yingying Shen, Yinghu Chen, Shibo Wang, Chengyan Zhang, Yuzhou He, Huajun Feng, Jiaoli Wang, Zhijian Cai

“…Abstract T‐cell haematological malignancies progress rapidly and have a high mortality rate and effective treatments are still lacking. Here, we developed a drug delivery system utilizing 293T cell‐derived extracellular vesicles (EVs) modified with an anti‐CD7 single‐chain variable fragment (αCD7/EVs). …”
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Dryland fungi are spatially heterogeneous and resistant to global change drivers by Andrea Lopez, Mark Anthony, Jovani Catalan‐Dibene, Scott Ferrenberg, Samuel E. Jordan, Brooke Osborne, Sasha Reed, Adriana L. Romero‐Olivares

“…Moreover, our results imply that the fungal community in our experiment was already adapted to the magnitude of stress imposed by two years of experimental disturbance and drought treatments. Overall, our study shows that the fungal community is spatially heterogeneous and resistant to global change drivers and houses many fungal species known for being stress tolerant and pathogenic.…”
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Co-Cultivations of <i>Beauveria bassiana</i>, <i>Metarhizium anisopliae</i>, and <i>Trichoderma harzianum</i> to Produce Bioactive Compounds for Application in Agriculture by Pauline Flores da Silva, Maicon Sérgio Nascimento dos Santos, Beatriz de Andrade Araújo, Bruno Douglas Kerber, Heloisa Alves Pinto de Oliveira, Jerson Vanderlei Carús Guedes, Marcio Antonio Mazutti, Marcus Vinícius Tres, Giovani Leone Zabot

“…Most of the highest values of conidia were obtained in the treatments at the central point, in which (g L⁻¹) glucose (20), sucrose (10), HAP (7.5), SMH (2.5), and HF (2.5) were used. …”
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Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…The pain duration decreased more with icatibant than with saline in two patients, whereas it decreased equally with both treatments in the other. Icatibant did not affect the changes in whole blood and plasma histamine, and serum angiotensin-converting enzyme levels after the induction of the dermal pain. …”
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Nosemosis negatively affects honeybee survival: experimental and meta-analytic evidence by Monika Ostap-Chec, Jessica Cait, R. Wilder Scott, Aneta Arct, Dawid Moroń, Marcin Rapacz, Krzysztof Miler

“…It is stressed that laboratory cage trials should be viewed as an initial step in evaluating the impact of Nosema on mortality and that complementary field and apiary studies are essential for identifying effective treatments to preserve honeybee populations.…”
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Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer by Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng

“…NKT and γδT cells are promising synergistic therapeutic cell types that may overcome the limitations of CD3 bispecific antibodies in pancreatic tumor treatments, offering a new perspective for clinical applications in immunotherapy.…”
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AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis by Javier Sánchez-Montejo, Miguel Marín, María Alejandra Villamizar-Monsalve, María del Carmen Vieira, Belén Vicente, Rafael Peláez, Julio López-Abán, Antonio Muro

“…Here we developed a semi-automated system based on YOLOv5 to capture photographs of 96 well microplates and use them for L1 count and morphological damage evaluation after experimental drug treatments. Material and methods Morphological properties were used to distinguish L1 from debris after pepsin muscle digestion and distinguish healthy (serpentine) or damaged (coiled) L1s after 72 h untreated or treated with albendazole or mebendazole cultures. …”
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Improving the efficacy of potato clonal micropropagation by inoculation with the rhizosphere bacteria <i>Azospirillum baldaniorum</i> Sp245 and <i>Ochrobactrum cytisi</i> IPA7.2 by K. Yu. Kargapolova, O. V. Tkachenko, G. I. Burygin, N. V. Evseeva, A. A. Shirokov, L. Yu. Matora, S. Yu. Shchyogolev

“…In both cultivars grown in the greenhouse, shoot growth was promoted in most inoculation treatments. The survival ability of the Nevsky microplants in the greenhouse increased 1.7-fold under the effect of simultaneous inoculation. …”
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