Influence of <i>Apis mellifera syriaca</i> Bee Venom on Nociception and Inflammatory Cytokine Profiles in Experimental Hyperalgesia by Mohamad Ayoub, Salma Fayjaloun, Rabih Roufayel, Dany El Obeid, Ziad Fajloun, Mohamad Rima, Marc Karam

“…Developing effective treatments that address the underlying mechanisms of hyperalgesia is an active field of research. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…These results led to over 5000 additional studies including carrier, prenatal and preimplantational tests or pharmacological and gene therapy treatments. Conclusion This strategy has shown promising improvements in the diagnostic rate, facilitating timely diagnosis and gradually expanding our services portfolio for rare diseases. …”
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Inhibition of glutathione peroxidase 4 suppresses gastric cancer peritoneal metastasis via regulation of RCC2 homeostasis by Can Hu, Jingli Xu, Yanqiang Zhang, Ruolan Zhang, Siwei Pan, Jiahui Chen, Yan Wang, Qianyu Zhao, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Shengjie Zhang, Dan Zu, Zhiyuan Xu, Ji Jing, Xiangdong Cheng

“…Gastric cancer (GC) is one of the most lethal malignancies due to high metastatic rate, making the identification of new therapeutic targets critical for developing effective anti-GC treatments. Glutathione peroxidase 4 (GPx4), a key regulator of ferroptosis and redox homeostasis, contributes to progression and influences patient survival. …”
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Effect of Nd:YAG Laser with/without Graphite Coating on Bonding of Lithium Disilicate Glass-Ceramic to Human Dentin by Amjad Abu Hasna, Stephanie Semmelmann, Fernanda Alves Feitosa, Danilo De Souza Andrade, Franklin R Tay, Cesar Rogério Pucci

“…This study evaluated the effect of different surface treatments on the tensile bond strength between lithium disilicate glass-ceramics, resin cement, and dentin. …”
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The effect of sulfadiazine in manure on accumulation of sulfonamide resistance genes in freshly consumable plants by Leo van Overbeek, Björn Berendsen, Stefan Aanstoot, Alex Bossers, Els Nijhuis, Lina Russ, Beatriz Andreo Jimenez

“…However, abundances of sul genes in rhizosphere soils was strongly determined by plant growth and not by soil treatments with SDZ-manure, which was also the case for the bacterial community composition. …”
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Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet by Cláudio A. Cunha, Fábio S. Lira, José C. Rosa Neto, Gustavo D. Pimentel, Gabriel I. H. Souza, Camila Morais Gonçalves da Silva, Cláudio T. de Souza, Eliane B. Ribeiro, Alexandra Christine Helena Frankland Sawaya, Cláudia M. Oller do Nascimento, Bruno Rodrigues, Patrícia de Oliveira Carvalho, Lila M. Oyama

“…The mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg body weight/day of green tea extract (CG and HG, resp.). The treatments were performed for eight weeks. UPLC showed that in 10 mg/mL green tea extract, there were 15 μg/mg epigallocatechin, 95 μg/mg epigallocatechin gallate, 20.8 μg/mg epicatechin gallate, and 4.9 μg/mg gallocatechin gallate. …”
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PPARα: A Master Regulator of Bilirubin Homeostasis by Cyril Bigo, Jenny Kaeding, Diala El Husseini, Iwona Rudkowska, Mélanie Verreault, Marie Claude Vohl, Olivier Barbier

“…Human hepatocytes (HH) and HepG2 cells sustained similar treatments, except that the expression of the bilirubin conjugating UDP-glucuronosyltransferase (UGT) 1A1 enzyme and multidrug resistance-associated protein (MRP) 2 transporter was analyzed. …”
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Variations in the performance, fruit shelf life, and mineral compositions of two varieties of pepper (Capsicum chinense ) grown under different soil amendments and seasons by Christopher Aboyeji, Aruna Adekiya, John Afolayan, Faith Okunlola, Barnabas Akaazua, Nifemi Adesola

“…Poultry manure (PM), Tithonia diversifolia (TD), cattle manure (CM), inorganic fertilizer (NPK 15:15:15), and the control (CTRL) were used as treatments.Method: Organic amendments were applied at a rate of 20 t ha-1, while NPK was applied at a rate of 180 kg ha-1. …”
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Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells by Ashok Singh, Anupama Singh, Jordan M. Sand, Erika Heninger, Bilal Bin Hafeez, Ajit K. Verma

“…Both single and chronic UVR treatments (1.8 kJ/m2) resulted in an increase in the frequency of double positive HSCs in PKCε TG mice as compared to their WT littermates. …”
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Anticancer, Antioxidant, Antimicrobial Activities, and HPLC Analysis of Alcoholic Extracts of Parthenocissus quinquefolia L. Plant Collected from Çanakkale by Sevil Kalın, Ersin Karabacak, Pınar Ilgın, Alper Önder, Özlem Maraba, Ferah Cömert Önder

“…The cell apoptosis with methanol extract was obtained between 20 µg/mL and 70 µg/mL for 48 h and 72 h treatments by Hoechst 33258 staining of nuclei under a fluorescence microscopy. …”
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Impacts of grazing management strategies on forage canopy structure in multi-species pastures during the wet-dry transition period by L. F. Penteado, A. C. L. Batista, A. F. B. Ongaro, M. M. Vieira, F. F. Simili, R. L. D. Costa, C. M. P. Barbosa, S. D. Simão, F. M. A. Gimenes

“…Aruana) and three legumes: Macrotyloma (Macrotyloma axillare), Calopo (Calopogoinum mucunoides), and Stylo (Stylosanthes macrocephala + Stylosanthes capitata). The treatments corresponded to four forage canopy heights (15, 30, 45, and 60 cm), and the grazing management strategies involved steady or variable stocking rates with sheep. …”
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Current virtual reality-based rehabilitation interventions in neuro-developmental disorders at developmental ages by Micaela Capobianco, Concetto Puzzo, Concetto Puzzo, Concetto Puzzo, Chiara Di Matteo, Alberto Costa, Alberto Costa, Walter Adriani, Walter Adriani, Walter Adriani

“…Specifically, in individuals with ADHD, VR showed benefits in attention and executive function, with optimal results when combined with pharmacological treatments. For ASD kids, VR proved effective in enhancing social skills and emotional regulation through personalized virtual scenarios. …”
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A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. However, current treatments only manage symptoms and lack the ability to slow or prevent disease progression. …”
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Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study by Rongrong Xu, Yanping Zhang, Tingting Wu, Hao Liu, Jianhao Peng, Zhanshan Wang, Te Ba, Baorong Zhang, Zhigang Li, Yongjie Wei

“…We conducted a randomized, crossover study among 35 healthy adults, who participated in 2-h exposure treatments in the road or park scenario alternately, to investigate the impact of short-term TRAP exposure on expiratory health. …”
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Isolation of a Novel Caprine <i>Eimeria christenseni</i> Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infect... by Emilio Barba, José Manuel Molina, Francisco Rodríguez, Otilia Ferrer, María Carmen Muñoz, Liliana M. R. Silva, María Cristina Del Río, José Adrián Molina, Anja Taubert, Carlos Hermosilla, Antonio Ruiz

“…Its biological similarities to highly pathogenic species such as <i>Eimeria ninakohlyakimovae</i> and <i>Eimeria arloingi</i> might enable comparative studies aimed at developing alternative strategies for drug treatments, including <i>Eimeria</i> species (strain)-specific vaccination strategies for the efficient control of goat coccidiosis.…”
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Chemical composition of marandu palisade grass fertilized with nitrogen and potassium by K. C. Sales, J. G. Abreu, C. E. A. Cabral, A. Behling Neto, L. C. R. P. Silva, I. M. Silva Neto

“…The experiment was carried out at the Experimental Farm of UFMT, Cuiabá Campus, from December to April 2017/2018 and 2018/2019 - rainy season; and from May to September in 2018 and 2019 – dry season. Treatments corresponded to a 5x2 factorial scheme, with five nitrogen doses (0; 25; 50; 75; 100 kg ha-¹) and two potassium doses (0; 25 kg ha-1). …”
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Investigating the Role of Gut Microbiota in Pediatric Patients with Severe COVID-19 or MIS-C by Elena Franchitti, Paolo Bottino, Francesca Sidoti, Andrea Carpino, Giulia Pruccoli, Ugo Ramenghi, Cristina Costa, Ugo Ala, Emilia Parodi, Deborah Traversi

“…In 75% of cases, pharmacological treatments included antibiotics and corticosteroids, which influenced the microbiota composition. …”
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Toward improving precision and complexity of transformer-based cost-sensitive learning models for plant disease detection by Manh-Tuan Do, Manh-Hung Ha, Duc-Chinh Nguyen, Oscal Tzyh-Chiang Chen, Oscal Tzyh-Chiang Chen

“…Early and accurate detection of plant diseases is crucial for making informed decisions to increase the yield and quality of crops through the decision of appropriate treatments. This study introduces an automated system for early disease detection in plants that enhanced a lightweight model based on the robust machine learning algorithm. …”
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Demographic clinical trial diversity assessment methods: Use of real-world data by Hua Chen, Nnadozie Emechebe, Sudeep Karve, Leon Raskin, Jailene Leal, Ning Cheng, Wendy Sebby, Kim Ribeiro, Samuel Crawford

“…Diversity in clinical trials is critical in identifying potential differences in safety and efficacy of treatments across races, ethnicities, ages, sexes, or other variables. …”
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Role of radiologists in the diagnosis and management of adrenal disorders by Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

“…Furthermore, radiologists have initiated treatments for unilateral PA, such as radiofrequency ablation, and play an integral role in the management of adrenal lesions. …”
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