Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment by Jiarui Lv, Yanan Wang, Jiacheng Lv, Cuiting Zheng, Xinyu Zhang, Linyan Wan, Jiayang Zhang, Fangming Liu, Hongbing Zhang

“…Our findings highlight the pivotal role of the mTOR-CREB1-SESN3 axis in sorafenib resistance of liver cancer and pave the way for combining pifithrin-μ and sorafenib for the treatment of mTOR-activated liver cancer.…”
Get full text

Evaluation of surgical treatment of gout-A retrospective study on 28 cases with tophi. by Ting Zhang, Bin Yang, Xiaohong Xu, Zengfang Zhang, Zhenglun Pan

“…Surgical intervention effectively reduced the frequency of gout flares, demonstrating short-term urate-lowering effects (STULE) and potential long-term urate-lowering effects (LTULE) when combined with urate-lowering treatments (ULT). Primary healing occurred in 65 out of 67 surgical sites (97.01%), with only 2 sites (2.99%) experiencing delayed healing, and minimal complications reported. …”
Get full text

Phase 4 Pharmacovigilance Trial of Paromomycin Injection for the Treatment of Visceral Leishmaniasis in India by Prabhat K. Sinha, T. K. Jha, Chandreshwar P. Thakur, Devendra Nath, Supriyo Mukherjee, Amrendra Kumar Aditya, Shyam Sundar

“…A phase 3 study demonstrated the safety and efficacy of paromomycin (paromomycin IM injection) for treatment of VL in an inpatient setting. Methods. This phase 4 study was conducted to assess the safety and efficacy of paromomycin in children and adults in an outpatient setting in Bihar, India. …”
Get full text

Clinical and molecular response to alpha1‐oleate treatment in patients with bladder cancer by Farhan Haq, Samudra Sabari, Jaromir Háček, Antonín Brisuda, Ines Ambite, Michele Cavalera, Parisa Esmaeili, Murphy Lam Yim Wan, Shahram Ahmadi, Marek Babjuk, Catharina Svanborg

“…Discussion and Conclusions These dose‐dependent anti‐tumor effects of alpha1‐oleate are promising and support the potential of alpha1‐oleate treatment in patients with NMIBC.…”
Get full text

Human Amniotic Membrane Positioning in the Surgical Treatment of Temporomandibular Joint Degenerative Disorder by Luca Guarda-Nardini, Diletta Trojan, Giulia Montagner, Elisa Cogliati, Matteo Bendini, Daniele Manfredini

“…Nonsurgical therapy is the traditional treatment of TMJ diseases but if ineffective, TMJ surgery can be performed and may include arthroplasty with interposition of autograft. …”
Get full text

From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments by Zhenlin Li, Zhenlin Li, Zhenlin Li, Zhenlin Li, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fujin Zhou, Fujin Zhou, Fujin Zhou, Dekun Song, Dekun Song, Dekun Song, Lunhui Chang, Lunhui Chang, Lunhui Chang, Lunhui Chang, Weiying Liu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang, Guolong Zhang

Get full text

Non-Destructive Evaluation of Thermal Treatment Influence on Elastic Engineering Parameters of Poplar by Tuğba Yılmaz Aydın, Murat Aydın

Subjects: Get full text

Sediment Concretion Treatment Experimental Study in Dongqian Lake Dredging and Filling Section by ZHANG Xuan-qi, JIANG Bo

Get full text

Incremental Healthcare Costs and Outpatient Antifungal Treatment of Patients with Aspergillosis in the United States by Emily Durden, Donna McMorrow, Paul Juneau, Robert Fowler, Paresh Chaudhari, David Horn

“…**Objectives:** To evaluate the total and outpatient economic burden of aspergillosis, and to describe the outpatient antifungal treatment of aspergillosis within a large, commercially-insured population in the United States. …”
Get full text

Investigating the Feasibility and Impact of Perinatal Depression Screening and Treatment in Rural Nsambe, Malawi by Waste Kayira, Mark Chalamanda, Kingsley Kanzoole, Kondwani Mpinga, Moses Banda Aron, Ksakred Kelly, Sarah Singer, Enoch Ndarama, Stephanie Smith, Giuseppe Raviola, Basimenye Nhlema, Emilia Connolly, Todd Ruderman

“…However, due to low resources and little evidence on the impact of screening and treatment, few interventions are offered. Our study aims to assess the feasibility and impact of depression symptoms with screening and treatment of women in rural Malawi. …”
Get full text

Co-infection with hepatitis B and human immunodeficiency virus: epidemiology, pathogenesis, and treatment by Yaozu He, Weiyin Lin, Fei Gu, Xianglong Lan, Linghua Li, Haijuan Wang

“…This study reviews the natural history and pathogenesis of liver disease in the context of HBV/HIV co-infection, current treatments for HBV in patients with HIV, and treatment outcomes in coinfected individuals.…”
Get full text

Inpatient Growth in Infants Requiring Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome by Ashajyothi M. Siddappa, Erin Morris, Michael D. Evans, Sarah Pelinka, Constance Adkisson

“…Conclusion: Infants with NOWS requiring pharmacologic treatment have a decrease in Z-scores for weight, length, and head circumference at birth and at hospital discharge. …”
Get full text

Effects of in-feed zeolite treatment on some biomarkers in dairy cows with subclinical mastitis by Dražen Đuričić, Silvijo Vince, Nino Maćešić, Damjan Gračner, Mislav Kovačić, Ivan Folnožić, Sonja Perkov, Marko Samardžija

“… In this study, the effects of in-feed clinoptilolite treatment on biomarkers such as serum amyloid A (SAA), haptoglobin, apolipoprotein A–I (APO A–I), and paraoxonase-1 (PON1) activity, triglycerides (TRIG) and high-density lipoprotein cholesterol are investigated in dairy cows with subclinical mastitis. …”
Get full text

A review: Exploring the role of ChatGPT in the diagnosis and treatment of oral pathologies by Payal Panwar, Shalini Gupta

Get full text

Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure by Carlo Alberto Cutolo, Chiara Bonzano, Carlo Catti, Alessandro Bagnis, Riccardo Scotto, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso

“…To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods. …”
Get full text

An Analysis of 3-Year Outcomes Following Canaloplasty for the Treatment of Open-Angle Glaucoma by Mahmoud A. Khaimi, Justin D. Dvorak, Kai Ding

Get full text

Stand-Alone Lateral Interbody Fusion for the Treatment of Low-Grade Degenerative Spondylolisthesis by Luis Marchi, Nitamar Abdala, Leonardo Oliveira, Rodrigo Amaral, Etevaldo Coutinho, Luiz Pimenta

“…The purpose of this paper was to investigate the stand-alone lateral interbody fusion as a minimally invasive option for the treatment of low-grade degenerative spondylolisthesis with a minimum 24-month followup. …”
Get full text

Multi-step pre-treatment of rice husk for fractionation of components including silica by Shinnosuke Ishida, Shinji Kudo, Shinji Kudo, Shusaku Asano, Shusaku Asano, Jun-ichiro Hayashi, Jun-ichiro Hayashi

Subjects: Get full text

Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma by Benjamin A. Derman, Jochen Reiser, Sanjib Basu, Agne Paner

Get full text

Approaches to the diagnosis of Cutaneous Diseases Among Swimmers: Causes, Symptoms, Prevention, Treatment by Patrycja Łazicka, Eliza Jakubowska, Julia Tarnowska

“…Aim The aim of this article is to discuss the main approaches to the diagnosis of dermatoses in swimmers, their prevention and treatment. Materials and methods  The review was based on the analysis of materials collected in the Google Scholar and,, PubMed’’. …”
Get full text