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121
Phenotypic alterations in articulating joint cells: Role of mechanically loaded MSC secretome
Published 2025-02-01“…Apart from their differentiation potential, MSCs secrete a multitude of molecules with therapeutic properties that benefit chondrogenesis and immunomodulation. Previously, we employed a small-panel microarray to demonstrate differences within conditioned medium (CM) of MSCs that were mechanically stimulated within a joint-mimicking bioreactor and their unloaded controls.This study analyzed the proteomic content within CM from 4 week mechanically loaded MSCs with a larger protein microarray. …”
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122
LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study
Published 2022-01-01“…Hydroxychloroquine (HCQ) was originally used as an antimalarial and immunomodulation drug. We developed and validated a simple and sensitive ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous quantitation of HCQ and its three metabolites in rat blood, and reported their pharmacokinetic parameters. …”
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123
1H NMR-Based Metabolic Profiling of Urine from Mice Fed Lentinula edodes-Derived Polysaccharides
Published 2018-09-01“…In conclusion, the present data is helpful to understand the mechanisms related to previously confirmed immunomodulation and anti-aging effects of L2, and provide valuable information for mining new functions of L2.…”
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124
Mesenchymal Stem Cell Therapy for Cardiac Inflammation: Immunomodulatory Properties and the Influence of Toll-Like Receptors
Published 2013-01-01“…Although reports are inconsistent, TLR3 activation may boost immunomodulation by MSC, while TLR4 activation suppresses it. …”
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125
Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Dise...
Published 2017-01-01“…Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW) APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA). …”
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126
IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials
Published 2025-03-01“…These encompassed a broad range of pharmacological mechanisms, including immunomodulation, cognitive enhancement, and hormonal, metabolic, and neurotransmitter modulation. …”
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127
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease
Published 2021-01-01“…Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. …”
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128
A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts
Published 2025-12-01“…Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of therapeutic biomolecules. …”
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129
Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex
Published 2025-11-01“…This review focuses on chemical and advanced structural information of glycoprotein, the regulation mechanism of immunomodulation and the structure-activity relationship, which aims to provide a theoretical basis for the basic research on the immunomodulatory activity of food-derived glycoproteins and the development of related functional products.…”
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130
Modified rice bran arabinoxylan as a nutraceutical in health and disease-A scoping review with bibliometric analysis.
Published 2023-01-01“…Beneficial effects of RBAC include immunomodulation, synergistic anticancer properties, hepatoprotection, antiinflammation, and antioxidation. …”
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131
Using fecal microbiota transplantation for animal health (review)
Published 2024-12-01“…Despite the lack of commonly accepted procedures, studies show that the fecal microbiota transplantation for the purposes of veterinary medicine can be used for a wide range of tasks: starting from disease prevention to immunomodulation. This review is devoted to the use of fecal microbiota transplantation for different animal species. …”
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132
An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp
Published 2015-01-01“…An understanding of the PRRs in dental pulp is important for immunomodulation and hence for developing therapeutic targets in the field of endodontics. …”
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133
Histological Structure of Spleen White Rat (Rattus norvegicus L.) After Induced of Nanochitosan Preparation of Neem Leaf (Azadirachta indica A. Juss) Ethanol Extract
Published 2024-12-01“…Agents of immunomodulation are compounds that have the ability to balance the immune system throughout the body. …”
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134
OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma
Published 2018-01-01“…Although much has been learned about Th1-favored immunomodulation of OK-432, a streptococcal preparation with antineoplastic activity, little is known about its adjuvant effect for allergic diseases. …”
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135
Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function
Published 2017-01-01“…Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. …”
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136
Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles
Published 2025-01-01“…Abstract Polymeric nanoparticles (NPs) are promising tools used for immunomodulation and drug delivery in various disease contexts. …”
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137
Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model
Published 2015-01-01“…Thus, we proposed in vitro assessment of adipose tissue-derived MSCs (AT-MSCs) immunomodulation on autoimmune response along with beta cell protection in streptozotocin- (STZ-) induced diabetic C57BL/6 mice model. …”
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138
Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star”
Published 2025-02-01“…In C. elegans, active ingredients such as catechins and their derivatives, L-theanine, and caffeine have exhibited various biological effects, including slowing down aging, enhancing environmental adaptations, regulating protein homeostasis and glycolipid metabolism, and participating in immunomodulation. The worms play a crucial role in studying the mechanisms of tea polyphenols and exploring the bioactivity of catechin derivatives. …”
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139
Interference in Macrophage Balance (M1/M2): The Mechanism of Action Responsible for the Anti-Inflammatory Effect of a Fluorophenyl-Substituted Imidazole
Published 2024-01-01“…Recently, an alternative has been presented by researchers to solve this problem: The immunomodulation of cells closely related to inflammation. …”
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140
Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain
Published 2016-01-01“…Data suggest that tDCS elicits its action through multifacetted mechanisms, including immunomodulation and neurogenesis, and thus support the idea of using tDCS to induce regeneration and to promote recovery of function. …”
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