Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…We have applied RNA sequencing, flow cytometry, ELISA, cellular/molecular immunological technology, and mouse models of solid cancers.Results Our study provided evidence that S1PR3 high expression is positively associated with resistance to programmed cell death protein-1 (PD-1)-based immunotherapy and increased T-cell exhaustion. …”
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Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular flui... by Chong Wang, Ying Feng, Yu Chen, Xianhua Lin, Xiangjuan Li

“…A significantly greater level of OSM (5.41 ± 2.65 vs. 3.94 ± 1.23 pg/mL, P=0.007) was detected in the serum of NOR patients via ELISA verification, and the sensitivity and specificity of ovarian reserve division were 50.00% and 83.33%, respectively.ConclusionThis study proposed that immunological changes assessed by PEA technology affect ovarian function in humans and that OSM may serve as a potential inflammatory biomarker for ovarian function in serum, thus revealing alterations in FF.…”
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Effects of dietary bile acid on the growth performance, intestinal health, blood biochemistry, and antioxidative response of Nile tilapia (Oreochromus niloticus) fed high-fat diets by Mahmoud A.O. Dawood, Sameh El-Dahan, Samy Elsaadawy, Ahmed E. Noreldin, Hani Sewilam

“…However, high-fat diets have a deleterious influence on aquatic species' metabolic and immunological functioning. Thereby, bile acid (BA) is proposed to relieve the lipid metabolism dysfunction, oxidative stress, and malnutrition caused by HF. …”
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Prospective directions for the development of means and methods for detection and fixation of handprints by V. V. Korniienko

“…A vacuum deposition method (VMD) has proven to be effective, making visible prints on the surfaces of four-year-old organic plastic. The direction of immunological research of the sebaceous trace of a finger for taking samples for a DNA profile remains relevant. …”
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A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease by Yin T, Zhang T, Ma L

“…The aim of this study was to screen immunologically related biomarkers for psoriasis and chronic kidney disease with the objective of identifying specific molecular markers to improve the accuracy and sensitivity of disease diagnosis.Patients and Methods: To achieve this objective, common differentially expressed genes between psoriasis and chronic kidney disease were first identified. …”
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Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case–Control Approach by Neha Sudhir, Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Tajinder Kaur, Anupam Kaur

“…The aetiological basis of RM has been traced to chromosomal, anatomic, hormonal and immunologic factors while half of the cases remain idiopathic. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…An important correlation exists between risk ratings and immunological checkpoints, which can be utilized to forecast the efficacy of treatment. …”
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Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review by Ahmed I. Edhi, Seifeldin Hakim, Christienne Shams, Damanpreet Bedi, Mitual Amin, Mitchell S. Cappell

“…Extensive evaluation for infectious, immunologic, and metabolic causes of liver disease was negative. …”
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The Effect of Autologous Platelet Rich Plasma on Endometrial Receptivity: A Narrative Review by Milan Stefanović, Predrag Vukomanović, Ranko Kutlesic, Milan Trenkić, Vanja Dimitrov, Aleksa Stefanović, Vladimir Cvetanović

“…Its major strengths are availability and proper application, which eliminates possible immunological reactions or disease transmission. The main drawbacks are not enough data on safety (i.e., its effect on endometriosis) and the lack of uniformity in the PRP preparation, which would provide optimal standardized quality and quantity of the PRP product and, thus, optimal treatment results.…”
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Helicobacter Pylori infection in systemic sclerosis and its association with upper gastrointestinal dysfunction by Chilukuri Balaji, Mahendran Bhuvanesh, Chinnadurai Saranya, Ramamoorthy Ramesh, Mayilsamy Saravanan, Sankaralingam Rajeswari

“…Demographic, clinical, laboratory, and immunological parameters were recorded. Upper gastrointestinal (GI) endoscopy was done. …”
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MODERN TREATMENT OF METASTATIC MELANOMA: FROM STANDARDS TO AN INDIVIDUALIZED APPROACH IN REAL CLINICAL PRACTICE by N. V. Zhukova, R. V. Orlova, N. Yu. Antimonik, S. I. Kutukova, N. P. Belyak, N. V. Popova, S. P. Erdniev

“…The appearance in a real clinical practice of a new group of immunological drugs (anti-CTLA4 and anti-PD-1) for the treatment of patients with metastatic melanoma allows to increase both the time to progression and the life span of this cohort of patients.In this article, we present the experience of St. …”
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Biological significance of soluble IL-2 receptor by Calogero Caruso, Giuseppina Candore, Diego Cigna, Antonio Tobia Colucci, Maria Assunta Modica

“…However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. …”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…The placenta has limited detoxifying capabilities and unique immunological regulation, making it especially sensitive to foreign particles. …”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,... by Malabi M Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar

“…Furthermore, this data will guide the list of immunological assays to be conducted for efficacy trials in different populations. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…While significant progress has been made in elucidating the pathophysiology of autoimmune diseases, the immunological mechanisms underlying anti‐NMDARE remain elusive. …”
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CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis by Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko

“…Late-onset rheumatoid arthritis (LORA) exhibits unique characteristics compared to other RA forms, suggesting distinct immunological mechanisms. This study aimed to examine the involvement of cytotoxic T cells in LORA. …”
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Effects of dietary Chlorella ellipsoidea on growth performance, body composition, and hematology of stinging catfish, Heteropneustes fossilis by Alam Asraful, Bristy Fouzia Sultana, Amzad Hossain M., Rabiul Islam M., Fatema Umme Kaniz, Golam Rasul M.

“…Based on the findings of the study, 5.0–10.0% C. ellipsoidea supplementation was optimal in the stinging catfish diet to improve growth performance, body composition, hematology, and immunological response. However, based on regression analysis, the optimum level of C. ellipsoidea as a feed supplement was calculated to be 4.9–5% in stinging catfish.…”
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Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…Included were four different types of immunological profiles: determinate cells (DC), proportional cells (PC), median brightness level (MBL), and morphological characteristics (MA). …”
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<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

“…In addition, EHVG showed immunological activity in the mice, considering immune cell distribution and cytokine production.…”
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Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB by Bai Y, Wang X, Wang B

“…However, there is a lack of research on the role of PDGFB in these processes.Methods: To address this issue, we conducted a comprehensive analysis utilizing multiple online databases to investigate the expression, prognostic, tumor stemness, and immunological effect of PDGFB. In addition, clinical samples were validated using immunohistochemistry.Results: Our findings revealed that PDGFB was highly expressed in a diverse range of cancer types, and its expression and genetic modifications were significantly associated with clinical outcomes in certain tumors. …”
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