Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Abstract Background For resectable adenocarcinoma of the esophagogastric junction (AEG), current treatment exploration primarily focuses on perioperative chemotherapy regimens combined with PD-1/PD-L1 inhibitors, but the long-term survival benefits of still require further investigation, and the use of upfront immunotherapy is typically restricted to patients with metastatic MSI-H (M1 MSI-H) disease due to their potential responsiveness to immunological agents. Adebrelimab, as a novel PD-L1 antibody, has not yet been proven for its efficacy and safety in adenocarcinoma of the esophagogastric junction. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

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Characterization of a chitinase from Trichinella spiralis and its immunomodulatory effects on allergic airway inflammation in mice by Jia Xu, Ye Yao, Qisheng Zhuang, Zixuan Li, Min Zhang, Shouan Wang, Hongxin Hu, Jianbin Ye

“…Research has been done to clarify the processes by which helminth-derived molecules can inhibit immunological disorders. This study aimed to evaluate the ability of Trichinella spiralis chitinase (Ts-chit) to ameliorate the symptoms of allergic airway inflammation. …”
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Enhancing broiler growth and carcass quality: impact of diets enriched with Moringa oleifera leaf powder conjugated with zinc nanoparticles by Mohammed M. El-Abbasy, Ahmed K. Aldhalmi, Elwy A. Ashour, Samar S. Bassiony, Mahmoud Kamal, Abdulmohsen H. Alqhtani, Diaa E. Abou-Kassem, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…In conclusion, supplementation with ZnNPs-MLPE at 2.0 and 3.0 cm³/L positively impacted broiler growth efficiency, antioxidant capacity, and immunological functionality. These findings support the potential of ZnNPs-MLPE as an effective natural growth enhancer for producing healthier poultry products.…”
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Effects of adding a kind of compound bio-enzyme to the diet on the production performance, serum immunity, and intestinal health of Pekin ducks by Yuxiao Li, Jie Zhou, Tong Guo, Huiya Zhang, Chang Cao, Yingjie Cai, Jiqiao Zhang, Tao Li, Jianqin Zhang

“…No substantial changes were observed in immunological parameters (P > 0.05). The jejunal villus height to crypt depth ratio (VH/CD) significantly increased (P < 0.001) in LG, with notable improvements in duodenal (P = 0.001) and jejunal (P < 0.001) VH/CD in HG. …”
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Utilizing the subtractive proteomics approach to design ensemble vaccine against Candida lusitaniae for immune response stimulation; a bioinformatics study. by Habiba Naz, Rimsha Timotheous, Muhammad Farhan Sarwar, Tariq Nadeem, Mudassar Fareed Awan, Sajed Ali, Sophia Awais, Irfan Ahmed

“…., to be non-homologous, was made in order to possess the ability to trigger an immunological response in host (humans). Furthermore, the whole proteome (WP) vaccine was constructed accordingly. …”
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Exclusive Breastfeeding Knowledge, Intention to Practice and Predictors among Primiparous Women in Enugu South-East, Nigeria by Chikaodili N. Ihudiebube-Splendor, Chinyelu B. Okafor, Agnes N. Anarado, Nonyelum N. Jisieike-Onuigbo, Anthonia U. Chinweuba, Ada C. Nwaneri, Joyce C. Arinze, Paulina C. Chikeme

“…Breastfeeding is considered as the most complete nutritional source for infants because breast milk contains the essential carbohydrates, fats, proteins, and immunological factors needed for infants to thrive and resist infection in the formative first year of life. …”
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Prevalence and trends of transfusion transmissible infections among blood donors in Basra, Iraq by Khairallah A S Mohammed, Maha M Hameed, Abdullah H Mousa, Amar T Saleh

“…A total of 197 898 samples were collected and screened for hepatitis B surface antigen (HBsAg), anti-hepatitis B core (HBc), anti-hepatitis C virus (HCV) and syphilis immunologically.Results The prevalence rates of seropositive of viral hepatitis for the year 2019, 2020, 2021 were as following: hepatitis B virus (HBV) rates 1.54%, 1.45% and 1.14% with significant declined trend by 26%; anti-HCV rates were 0.14, 0.12 and 0.11% with significant declined trend by 21.4%; and the syphilis rates were 0.38, 0.47, 0.36 with marked declined trend 5.3%, respectively.Of those donors showed HBV positive, 2503 (1.26%) had positive anti-HBc results, while only 173 (0.0874) showed positive test results for both anti-HBc and HBsAg.Conclusion Prevalence rates of viral hepatitis and syphilis showed a steady decline between 2019 and 2021, and these rates were much lower in Basra than in other parts of Iraq and neighbouring countries. …”
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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metast... by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

“…This phase I trial evaluated safety, efficacy and pharmacodynamics of pixatimod and PD-1 inhibitor nivolumab in immunologically cold cancers.Methods 3+3 dose escalation with microsatellite stable metastatic colorectal cancer (MSS mCRC) and metastatic pancreatic ductal adenocarcinoma (mPDAC) expansion cohorts. …”
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Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy by Saeko Asano, Tatsuhito Himeno, Tomohide Hayami, Mikio Motegi, Rieko Inoue, Hiromi Nakai-Shimoda, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Jiro Nakamura, Hideki Kamiya

“…After the culture, neurite outgrowth was quantified using immunological staining. Sensory nerve conduction velocity increased in diabetic rats treated with ranirestat (43.3±3.6 m/s) compared with rats treated with placebo (39.8±2.3). …”
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Effects of Substituting Soybean Meal With Winged Bean on Growth, Physiological Function and Flesh Quality of Indian Butter Catfish (Ompok bimaculatus) by Jaya Angom, Soibam Khogen Singh, Ayam Gangarani Devi, Pronob Das, Pradyut Biswas, Gusheinzed Waikhom, Soibam Ngasotter, Reshmi Debbarma, Sourabh Debbarma, Nitesh Kumar Yadav

“…Haematological and immunological parameters indicated improved fish health at the 25% substitution level. …”
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Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxyg... by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

“…Background: The immunologic factors are the chief reason for recurrent pregnancy loss (RPL) and induction ofmaternal-fetal tolerance is the main treatment for this cause of RPL, but the effect of this method is uncertainly andneeds multiple doses and/or interventions. …”
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Vaccination status and hepatitis A immunity in children: insights from a large-scale study in Turkey by Metin Yigit, Furkan Kalayci

“…Methods Data from 9,858 patients, collected between August 2019 and March 2024, were analyzed to evaluate the immunological response to the vaccine. Patients were categorized into four groups based on vaccination status: under-vaccinated (children 6–18 months old), single-dose vaccinated (children 18–24 months old), fully vaccinated (children over 24 months old born after March 1, 2011), and unvaccinated (born before March 1, 2011, when routine hepatitis A vaccination began). …”
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Development of a Human Intestinal Organoid Model for In Vitro Studies on Gut Inflammation and Fibrosis by Leonidas Kandilogiannakis, Eirini Filidou, Ioannis Drygiannakis, Gesthimani Tarapatzi, Stylianos Didaskalou, Maria Koffa, Konstantinos Arvanitidis, Giorgos Bamias, Vassilis Valatas, Vasilis Paspaliaris, George Kolios

“…We also investigated the effect of inflammatory stimuli on the expression of fibrotic and immunological mediators. Serial evaluation of the expression of mesenchymal and extracellular matrix (ECM) markers revealed that HIOs have an adequately developed mesenchymal component, which gradually declines through culture passages. …”
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Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances by Kenneth N. Kikanme, Adcharee Karnjanapiboonwong, Rameshkumar Angappan, Nicole M. Dennis, Farzana Hossain, Jamie G. Suski, Christopher J. Salice, Todd A. Anderson

“…Research has revealed that exposure to environmentally relevant concentrations of PFAS can reduce reproductive success and have immunological effects in laboratory animals, including birds. …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Background Immunological contexture differs across malignancies, and understanding it in the tumor microenvironment (TME) is essential for development of new anticancer agents in order to achieve synergistic effects with anti-programmed cell death protein-1 (PD-1) therapy. …”
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Acute hepatitis of non-specified etiology by Ye. V. Tsyganova, O. O. Znoyko, N. D. Yushchuk, K. R. Dudina, M. G. Isagulyants, N. V. Petrakova, T. V. Petrova, M. I. Mikhaylov

“…Investigation of patients with acute hepatitis of non-specified etiology included clinical, epidemiologic, routine laboratory, serological methods; molecular biological method (RNA of hepatitis A, C, Е, G viruses; DNA of hepatitis B virus, TTV, CMV, EBV, HHV of 1, 2, 6 and 8 types, PV B-19, NV-f – qualitative analysis); method of immunofluorescence (assessment of antimitochondrial and antinuclear antibodies); immunologic methods (laboratory diagnostic methods) – independent assessment of specific antibodies for individual HCV antigens spectrum, including structural and unstructural proteins and compound peptides, representing the whole HCV polyprotein (overall 38 antigens: 34 HCV antigens and 4 control antigens) in blood serum by EIA method; investigation of Т-cellular immune response to HCV antigens by blast-cell lymphocytes transformation method under stimulation by HCV antigens with quantitative evaluation of cytokine secretion; instrumental method – ultrasound investigation of abdominal organs.Conclusions. …”
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Effects of Dietary Protein-to-Energy Ratios on Growth, Immune Response, Antioxidative Capacity, Liver and Intestinal Histology, and Growth-Related Gene Expression in Hybrid Yellow... by Sehrish Taj, Quan Han, Xiaoyi Wu, Haoran Yin, Lixia Tian, Huijun Yang, Yongjian Liu, Junwa Huang

“…This study is aimed at evaluating the effects of dietary protein-to-energy ratios on the growth, immunological response, antioxidative capacity, liver and intestinal histology, and growth-related gene expression of hybrid yellow catfish (Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂). …”
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Protective potential of structural proteins of the SARS-CoV-2 virus in protecting against COVID-19 by Inna V. Dolzhikova, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Anna V. Kovyrshina, Olga V. Zubkova, Olga D. Popova, Tatiana A. Ozharovskaya, Denis I. Zrelkin, Daria M. Savina, Ekaterina G. Samokhvalova, Amir I. Tukhvatulin, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Various genetic, virological and immunological methods, as well as methods of working with animals, were used in the study. …”
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Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes by Anoushka Saxena, Minal, Prabhjyoti Pahwa, Jaswinder Singh Maras, Hamda Siddiqui, Jayesh Kumar Sevak, Yedla Manikya Mala, Shakun Tyagi, Shiv K. Sarin, Nirupama Trehanpati

“…This study investigates the HEV-associated metabolomic and immunological changes to elucidate the worsening of obstetric outcomes in patients with acute liver failure (ALF) due to HEV. …”
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