Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a serious, sometimes lethal, immunological reaction to drug metabolites involving multiple organ systems. …”
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TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Moreover, combo-therapy led to full regression of 4T-1 tumors in a large percentage of mice, who became strongly resistant to secondary tumor challenge, a clear indication of antitumor immunological memory. The cisplatin+CR108 combo therapy holds promise in converting “cold” tumors into “hot” ones and eliciting robust antitumor immune responses in vivo.…”
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Clinical profile and outcomes analysis of HIV infection by Ashwant Kumar, Yoganathan Chidambaram, Clement J. Dhas, Nekkanti Abilash, Murali Alagesan

“…Nearly 38% of participants showed a combination of clinical, immunological, and virological failures. Renal tubular necrosis (5%) was the most common adverse effect of HAART, while 1% developed immune reconstitution inflammatory syndrome. …”
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Clinical Use of Dostarlimab in Advanced Stage and Recurrent Endometrial Cancer: Patient Selection and Perspectives by Bujnak AC, File B, Tewari KS

“…On August 1st, 2024, the United States Food and Drug Administration expanded the indication of the immunologic anti-PD-1 checkpoint inhibitor, dostarlimab, and chemotherapy in endometrial cancer. …”
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Combination Treatments of Plasma Exchange and Umbilical Cord-Derived Mesenchymal Stem Cell Transplantation for Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failur... by Wen-xiong Xu, Hong-liang He, Shun-wen Pan, Yuan-li Chen, Mei-ling Zhang, Shu Zhu, Zhi-liang Gao, Liang Peng, Jian-guo Li

“…The hepatic function, coagulation, and virological and immunological markers were assessed at baseline and 30, 60, 90, 180, and 360 days. …”
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Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): safety, efficacy, and exploratory biomarker analysis by Jeff Clarke, Xiaofei Wang, Thomas Stinchcombe, Scott J Antonia, Jeffrey Crawford, Neal Ready, Konstantin H Dragnev, Lin Gu, Cameron Wood, James M Isaacs, Liliana Lyniv, Kent Weinhold, Jacob M Kaufman, Eziafa I Oduah, Betty C Tong, Dennis Wigle

“…Background Our study was designed to determine the safety, efficacy, and immunological effects of perioperative pembrolizumab in early-stage NSCLC.Methods This is a single-arm phase II study of perioperative pembrolizumab in patients with untreated, clinical stage IB to IIIA NSCLC. …”
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Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…This study shows that the immunologically important class II antigens in human cells are up-regulated predominately via the same pathway after gamma-interferon (γ-IFN) treatment, whereas murine cells are activated by other signalling routes. …”
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Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo

“…Methods We performed a comparative single‐cell RNAsequencing (scRNA‐seq) analysis on tumour and adjacent para‐tumour tissues fromMPLC and SPLC patients to comparatively evaluate their immunological landscapes.Additionally, multiplex immunofluorescence (mIF) staining and independentvalidation datasets were used to confirm findings. …”
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Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA by Rayan Najjar, Xiaoxing Wang, Jose Mario Bello Pineda, Hugh Alessi, Alison Bays, Robert K. Bradley, James N. Jarvis, Tomas Mustelin

“…Results Neutrophils from patients with SLE contained 521 statistically significant altered mRNA splicing events compared with healthy donor neutrophils, many of them affecting important immunologic pathways, myeloid function, transcription factors, and proteins involved in mRNA splicing. …”
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Frequency of 25-Hydroxyvitamin D Deficiency in Pediatric Patients with Immune Thrombocytopenia: Disease Phase and Therapy Options by Huda K. Abbas, Basil O. Saleh, Hassanain H. Ghali

“… Background: Hypovitaminosis D can cause immunological irregularities in the development of immune thrombocytopenia. …”
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Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort by Conti Fabrizio, Ceccarelli Fulvia, Perricone Carlo, Massaro Laura, Marocchi Elisa, Miranda Francesca, Spinelli Francesca Romana, Truglia Simona, Alessandri Cristiano, Valesini Guido

“…Anti-dsDNA status influences the clinical and immunological features of SLE patients. Nonetheless, it does not appear to affect disease activity.…”
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Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes by Jia Qu, Mei-Huan Wang, Yue-Hua Gao, Hua-Wei Zhang

“…Consensus clustering effectively categorized BC patients into two distinct clusters, with cluster B demonstrating a longer OS and a more favorable prognosis. Immunological assessments indicated a higher presence of immune checkpoints and immune cells in cluster B, suggesting a greater likelihood of responsiveness to ICIs. …”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…The immune response contributes to pulmonary artery remodeling and OSA-related diseases. The immunologic factors linked to OSA-induced PH are not well understood. …”
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Impact of dietary Spirulina on performance, antioxidant status, carcass traits and pathological alteration in broilers exposed to ochratoxin A stress by Ayman S. Salah, Mahmoud S. El-Tarabany, Marwa Mostafa, Rania Samir Zaki, Mahmoud M. Azzam, Omnia I. El Euony, Mahmoud Alagawany, Antonia Lestingi, Ahmed A. Elolimy, Mahmoud Madkour, Ahmed Fotouh

“…The duration of this study was six weeks, during which the experimental groups were organized as follows: G1 consumed a basal diet (control), G2 consumed a basal diet treated with OTA at a level of 1 mg/kg of diet, G3 consumed a basal diet treated with Spirulina platensis at a level of 1 g/kg of diet, G4 consumed a basal diet treated with OTA at a level of 1 mg/kg of diet and Spirulina platensis at a level of 1 g/kg diet.Results and discussionThe results illustrated that OTA-contaminated feed resulted in a significant elevation in total cholesterol, triglyceride, low- and very low density lipoprotein, and malondialdehyde, along with a significant reduction in antioxidant status and immunological response. On the other hand, Spirulina supplementation significantly enhanced performance performance (body weight, body weight gain and feed conversion ratio). …”
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Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. Finally, the esophageal microbiome could be the protagonist to be investigated, deepening our understanding of the subtle association between the host microbiota and tumor development.…”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Beatriz Tavira, Hugo Barcenilla, Jeannette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Rosaura Casas

“…Patients responding clinically best account for most of the immunological changes. In contrast, SC treatment resulted in predominant IgG1, predominant IFN-γ, higher proliferation, and activated CD4 and CD8 cells. …”
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Clinical manifestations in Egyptian Pompe disease patients: Molecular variability and enzyme replacement therapy (ERT) outcomes by Mohamed Abdelghafar Hussein, Heba ElTaher, Ranim Mahmoud, Donia Sobh, Mohammad Al-Haggar

“…We evaluated their phenotype, genotype, radiological and laboratory findings including their cross-reactive immunologic material (CRIM) status. Infantile Pompe disease was diagnosed by measurement of the activity of the enzyme alpha-glucosidase. …”
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Disease resistance traits of IPB-D2 chickens: Characterization of IgY concentrations, Newcastle disease antibody titers, and leukocyte profiles by Dwi Lestari, Sri Murtini, Niken Ulupi, Asep Gunawan, Isyana Khaerunnisa, Anneke Anggraeni, Cece Sumantri

“…This study aimed to characterize the disease resistance traits of IPB-D2 chickens by analyzing key immunological parameters, including immunoglobulin Y (IgY) concentration, Newcastle disease (ND) antibody titers, and leukocyte profiles. …”
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Dengue Infection and Its Relationship with Evans Syndrome: A Pediatric Case by Ivan Jose Ardila Gomez, Pilar Pérez López, Mónika Rocío Hernández Carreño, Juan Camilo Barrios Torres

“…Here, we present the case of an unusual hematological and immunological complication of a patient who developed Evans syndrome during severe dengue, taking into account the concomitantly limited literature available for these two diseases, the need for a broader diagnostic approach, multidisciplinary intervention, and a more complex therapeutic approach.…”
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Effect of prolonged starvation on nutrition utilization and transcriptional responses in Pacific oyster (Crassostrea gigas) by Mingkun Liu, Chenchen Wei, Wenwen Xu, Lintao Tan, Li Li, Guofan Zhang

“…This pattern strongly supported the stepped change pattern identified by nutrient utilization. In contrast, immunological functions initially decreased before increasing, whereas functions related to cell growth and survival showed a consistent downward trend. …”
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