The Uncoupling of Disease Activity from Joint Structural Progression in Patients with Rheumatoid Arthritis Treated with Filgotinib by Yoshiya Tanaka, Tatsuya Atsumi, Daniel Aletaha, Hendrik Schulze-Koops, Haruhiko Fukada, Chris Watson, Tsutomu Takeuchi

Get full text

Myeloid Disease with the CSF3R T618I Mutation after CLL by Maria Eduarda Couto, Susana Bizarro, Domingos Sousa, Nelson Domingues, Isabel Oliveira, Gabriela Martins, Manuel R. Teixeira, Mário Mariz

Get full text

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…Shuhan Liu,1– 3 Haisong Li,4 Shiwen Xi,1,2 Yuning Zhang,1,2,* Tianmeng Sun1,2,5,6,* 1Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, People’s Republic of China; 3Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 5International Center of Future Science, Jilin University, Changchun, People’s Republic of China; 6State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianmeng Sun; Yuning Zhang, The First Hospital of Jilin University, 71 Xinmin St, Changchun, Jilin, People’s Republic of China, Email tsun41@jlu.edu.cn; zhangyuning@jlu.edu.cnAbstract: Given the complexity of the central nervous system (CNS) and the diversity of neurological conditions, the increasing prevalence of neurological disorders poses a significant challenge to modern medicine. …”
Get full text

Bacterial Profile among Patients with Suspected Bloodstream Infections in Ethiopia: A Systematic Review and Meta-Analysis by Birhan Alemnew, Habtamu Biazin, Asmamaw Demis, Melese Abate Reta

Get full text

Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response by Michal Holub, Alžběta Stráníková, Pavel Chalupa, Simona Arientová, Kateřina Roubalová, Ondřej Beran

Get full text

Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells by Monia Orciani, Miriam Caffarini, Alessandra Biagini, Guendalina Lucarini, Giovanni Delli Carpini, Antonella Berretta, Roberto Di Primio, Andrea Ciavattini

Get full text

Vascular Endothelial Growth Factor in Tear Samples of Patients with Systemic Sclerosis by Anikó Rentka, Jolán Hársfalvi, András Berta, Krisztina Köröskényi, Zoltán Szekanecz, Gabriella Szücs, Peter Szodoray, Ádám Kemény-Beke

Get full text

Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study by Kebede Embaye Gezae, Kiflom Hagos, Assefa Ayalew Gebreslassie

Get full text

Infection control Surveillance of dialysis events at outpatient hemodialysis centers in Saudi Arabia: A 3-year national data by Mohammed ALQahtani, Aiman El-Saed, Faisal Alsheddi, Ahlam H. Alamri, Atef M. Shibl, Khalid H. Alanazi

Get full text

Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy by Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

Get full text

Epidemiologic Investigation of Intestinal Parasite Infection and Associated Risk Factors among Primary Schoolchildren in the Manzini and Lubombo Provinces, the Kingdom of Eswatini by Ai-Wen Yin, Yueh-Lun Lee, Sindisiwe Dlamini, Gugu Maphalala, Chien-Wei Liao, Chia-Kwung Fan

Get full text

Design and assembly of plant-based COVID-19 candidate vaccines: reсent development and future prospects by E. A. Uvarova, P. A. Belavin, E. V. Deineko

“…The world scientific community is making tremendous efforts to develop means of protection, prevention and treatment of this disease based on modern advances in molecular biology, immunology and vaccinology. This review provides information on the current state of research in the field of vaccine development against COVID-19 with an emphasis on the role of plants in solving this complex problem. …”
Get full text

Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics by Thomas Vaissiere, Sheldon D. Michaelson, Thomas Creson, Jessie Goins, Daniel Fürth, Diana Balazsfi, Camilo Rojas, Randall Golovin, Konstantinos Meletis, Courtney A. Miller, Daniel O’Connor, Lorenzo Fontolan, Gavin Rumbaugh

Get full text

Virtual consultation in kidney care: a mixed-methods study on a model for safe and effective integration into routine clinical care by Aminu K Bello, Stephanie Thompson, Deenaz Zaidi, Scott Klarenbach, Feng Ye, Terry J Smith, Mark Courtney

Get full text

Structural characteristics, functions, and counteracting strategies of biofilms in Staphylococcus aureus by Yanze Xia, Zhenghui Hu, Qiyuan Jin, Qi Chen, Chenhao Zhao, Rui Qiang, Zonggang Xie, Liubing Li, Haifang Zhang

Get full text

Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

Get full text

Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning by Jindou Shi, Alexander Ho, Corey E. Snyder, Eric J. Chaney, Janet E. Sorrells, Aneesh Alex, Remben Talaban, Darold R. Spillman, Marina Marjanovic, Minh Doan, Gary Finka, Steve R. Hood, Stephen A. Boppart

“…The techniques have potential for broader single-cell characterization applications in stem cell research, immunology, cancer biology and beyond.…”
Get full text

Targeting Caveolin‐1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell‐Mediated Immunotherapy by Dewen Zhan, Zhimin Du, Shang Zhang, Juanru Huang, Jian Zhang, Hui Zhang, Zhongrui Liu, Eline Menu, Jinheng Wang

Get full text

Prevalence and consequences of bovine subclinical mastitis in hill tract areas of the Chattogram division, Bangladesh by Md. Piplu Mia, Hemayet Hossain, Khadiza Akter Brishty, Md. Shahidur Rahman Chowdhury, Md. Imranuzzaman, Mostafizor Rahman, Sadia Islam Ria, Milon Mia, Md Saidul Haque, Md. Ashik-uz-zaman, Md. Nazmul Haque, Anzuman Ara, Md. Masudur Rahman, Md. Mahfujur Rahman

Get full text

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice by Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F

“…Léa Gherardi,* Lucie Aubergeon,* Mélanie Sayah, Jean-Daniel Fauny, Hélène Dumortier, Fanny Monneaux CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France*These authors contributed equally to this workCorrespondence: Fanny Monneaux, CNRS UPR3572, Institut de Biologie Moléculaire et Cellulaire, 2 Allée Konrad Roentgen, Strasbourg, 67084, France, Email f.monneaux@ibmc-cnrs.unistra.frPurpose: The co-inhibitory receptor B and T Lymphocyte Attenuator (BTLA) negatively regulates B and T cell activation. …”
Get full text