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Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism
Published 2025-01-01“…Lacidipine activates effector T cells and incapacitates regulatory T cells (Tregs) to augment the anti‐tumor effect of chemotherapeutic agents in breast cancer by converting immunologically “cold” into “hot” tumors. Mechanistically, lacidipine targets calcium channels (CaV1.2/1.3) to inhibit Pyk2‐JAK1‐calmodulin complex‐mediated IDO1 transcription suppression, which suppresses the kynurenine pathway and maintains the total nicotinamide adenine dinucleotide (NAD) pool by regulating NAD biosynthesis. …”
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COMPARATIVE STUDY OF TIME ECHO VARIATIONS IN THE METABOLITE VALUES MR BRAIN SPECTROSCOPY
Published 2024-07-01Get full text
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Morphometric characteristics of organs of female chickens (Pazo de Vilane) supplemented with Curcuma longa
Published 2025-01-01“…Therefore, more studies at the level of immunology and histology are recommended to support the benefits of C. longa.…”
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BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression
Published 2025-01-01Get full text
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The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?
Published 2018-01-01Get full text
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The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level
Published 2022-01-01Get full text
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Effectiveness of an HIV peer support precision matching platform: a randomized controlled trial protocol
Published 2024-10-01Get full text
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Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia
Published 2025-01-01Get full text
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Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
Published 2019-01-01Get full text
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2024 Polish recommendations for the management of familial hypercholesterolemia in children and adolescents
Published 2024-11-01Get full text
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Role of Regulatory B Cells in the Progression of Cervical Cancer
Published 2019-01-01Get full text
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Evaluation of a new biomarker 14-3-3 Eta protein in diagnosis of rheumatoid arthritis
Published 2020-01-01“…Settings and Design: This was cross sectional case control study by the Departments of Biochemistry and Rheumatology and clinical immunology. Subjects and Methods: A total of 61 RA cases and 20 healthy controls were included. …”
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