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    Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism by Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang

    Published 2025-01-01
    “…Lacidipine activates effector T cells and incapacitates regulatory T cells (Tregs) to augment the anti‐tumor effect of chemotherapeutic agents in breast cancer by converting immunologically “cold” into “hot” tumors. Mechanistically, lacidipine targets calcium channels (CaV1.2/1.3) to inhibit Pyk2‐JAK1‐calmodulin complex‐mediated IDO1 transcription suppression, which suppresses the kynurenine pathway and maintains the total nicotinamide adenine dinucleotide (NAD) pool by regulating NAD biosynthesis. …”
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    Evaluation of a new biomarker 14-3-3 Eta protein in diagnosis of rheumatoid arthritis by Lakshmi Deepika Yarlagadda, Rachel Jacob, D Liza Rajasekhar, Krishna Mohan Iyyapu, Sai Baba S S. Kompella, Vijaya Bhaskar Madrol, N N Sreedevi, Siraj Ahmed Khan, Noorjahan Mohammed

    Published 2020-01-01
    “…Settings and Design: This was cross sectional case control study by the Departments of Biochemistry and Rheumatology and clinical immunology. Subjects and Methods: A total of 61 RA cases and 20 healthy controls were included. …”
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