Long-term sublingual bacterial immunotherapy prevents ear, nose and throat infections: A real-life study by Paula F Aarestrup, Matheus F Aarestrup, Beatriz JV Aarestrup, Edir P Cheloni, Fernando M Aarestrup

“…Recent findings suggest that immunity can be trained by inducing an immunological memory in both the innate and acquired immune response. …”
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Protocol for differentiating cardiomyocytes and generating engineered heart tissues from human feeder-free extended pluripotent stem cells by Zhongjun Wan, Shanshan Wen, Ran Zheng, Li Li, Wei Jiang, Donghui Zhang

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Evaluation of Metalloproteinase-8 Levels in Crevicular Fluid of Patients with Healthy Implants or Periodontitis by Paweł Aleksandrowicz, Paulina Żelechowska, Justyna Agier, Katarzyna Starska, Krzysztof Kędzierski, Joanna Wysokińska-Miszczuk, Ewa Brzezińska-Błaszczyk

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Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines by Aziz A. Chentoufi, Jeffrey B. Ulmer, Lbachir BenMohamed

“…This review will (1) present the current state of antigen delivery platforms involving a multifaceted approach, including bioinformatics, molecular and structural biology, immunology, and advanced computational methods; (2) discuss the challenges facing the development of safe and effective antigen delivery platforms; and (3) highlight the potential of nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNP) as the platform that is well suited to the needs of a next-generation pan-CoV vaccine, such as the ability to induce broad-based immunity and amenable to large-scale manufacturing to safely provide durable protective immunity against current and future Coronavirus threats.…”
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Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt by Shaymaa H. Abdel-Rhman, Rehab M. Elbargisy, Dina E. Rizk

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Dual-targeting CAR T cells for B-cell acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma by Gustavo de Oliveira Canedo, Claire Roddie, Persis J. Amrolia

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Immunogenicity of Pfizer mRNA COVID-19 Vaccination Followed by J&J Adenovirus COVID-19 Vaccination in Two Patients with Chronic Lymphocytic Leukemia by Zoe L. Lyski, Myung Sun Kim, David Xthona Lee, David Sampson, Hans-Peter Raué, Vikram Raghunathan, Debbie Ryan, Amanda E. Brunton, Mark K. Slifka, William B. Messer, Stephen E. Spurgeon

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Extent and Resistance Patterns of ESKAPE Pathogens Isolated in Pus Swabs from Hospitalized Patients by Salim S. Masoud, Anna Kovacevich, Raidah Gangji, Helmut Nyawale, Mary Nyange, Albert Ntukula

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The Passage of Chaperonins to Extracellular Locations in <i>Legionella pneumophila</i> Requires a Functional Dot/Icm System by Peter Robertson, David S. Allan, Rafael A. Garduño

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Ischemia Elicits a Coordinated Expression of Pro-Survival Proteins in Mouse Myocardium by Deborah Lyn, Shaojia Bao, Nicole A. Bennett, Xiaowei Liu, Nerimiah L. Emmett

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The Viral Load of Human Cytomegalovirus Infection in Children following Hematopoietic Stem Cell Transplant by Chip Digital PCR by Wen-Jun Wang, Miao Feng, Feng He, Juan Song, Qin-Qin Song, Dong Xia, Rong Liu, Hai-Lan Yao, Jun Han

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Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

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Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide by Jeffrey S. Rush, Svetlana Zamakhaeva, Nicholas R. Murner, Pan Deng, Andrew J. Morris, Cameron W. Kenner, Ian Black, Christian Heiss, Parastoo Azadi, Konstantin V. Korotkov, Göran Widmalm, Natalia Korotkova

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Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches by Dmitriy Lapin, Archna Sharma, Ping Wang

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Enhanced Immunogenicity of Foot-and-Mouth Disease Virus-like Particles Using a Water-in-Oil-in-Water Adjuvant by Yujie Zhou, Wenzhu Yin, Zhidong Teng, Yanyan Zhao, Yu Lu, Yingjuan Qian, Bihua Deng

“…BALB/c mice were immunized with the VLPs+WT vaccine, and immunological responses were assessed through antibody measurements, cytokine profiling, and gene expression analysis. …”
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Myocardial Gene Expression of T-bet, GATA-3, Ror-γt, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response by Luciana Gabriel Nogueira, Ronaldo Honorato Barros Santos, Alfredo Inácio Fiorelli, Eliane Conti Mairena, Luiz Alberto Benvenuti, Edimar Alcides Bocchi, Noedir Antonio Stolf, Jorge Kalil, Edecio Cunha-Neto

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Prevalence and Detection of qac Genes from Disinfectant-Resistant Staphylococcus aureus Isolated from Salon Tools in Ishaka Town, Bushenyi District of Uganda by Solange Gahongayire, Adamu Almustapha Aliero, Charles Drago Kato, Alice Namatovu

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Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice by Sadako Nakamura, Naoyuki Kondo, Yoshitake Yamaguchi, Michiru Hashiguchi, Kenichi Tanabe, Chihiro Ushiroda, Miho Kawahashi-Tokuhisa, Katsuyuki Yui, Mana Miyakoda, Tsuneyuki Oku

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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

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Isotype diversity of antibodies specific for component allergens in the context of allergic diseases: eosinophilic esophagitis (EoE), asthma, and the alpha-gal syndrome (AGS) by Thomas A. E. Platts-Mills, Matthew H. MacCallum, Jeffrey M. Wilson, Lisa J. Workman, Elizabeth A. Erwin

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