Conjugation of Daunorubicin to Monoclonal Antihuman Sarcoma Antibody by a Novel Method by Michel Pagé, Denis Thibeault, Hélène Tremblay, Christiane Noël, Marie-Josée Perron

“…Most of the reported methods for coupling anthracycline drugs to antibody result in either a loss of pharmacological activity or yield antibodies which have lost much of their immunological specificity. The use of glutaraldehyde for coupling saves both the pharmacological and immunological activities but it causes some polymerization of the antibody or of the macromolecular carrier which is undesirable for in vivo use. …”
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Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…The discovery of new immunological factors and a better understanding of psoriasis have turned to the use of immunological pathways and could develop new biological drugs against specific immunological elements that cause psoriasis. …”
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Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface by Daniel Damiani, Aline Ribeiro de Bem

“…The etiologies behind these diseases are represented by paraneoplastic syndromes (including occult tumors) as well as viral infections, in both cases constituting true immunological triggers with exposure of antigens that will lead to a cross-immunological response directed at healthy structures of the nervous system. …”
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Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes? by Datis Kharrazian, Martha Herbert, Aristo Vojdani

“…However, we identified strong to moderate immunological reactivity with antibodies against insulin receptor alpha, ZnT8, IA2, GAD-65, and GAD-67 with several dietary proteins. …”
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Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion by Mehmet Erdem Çakmak, Nida Oztop, Osman Ozan Yeğit

“…Hypersensitivity reactions may develop with both immunological and non-immunological mechanisms. 5-FU infusion chemotherapy may cause early types of life-threatening hypersensitivity reactions. …”
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Impact of Combined Antiretroviral Treatment (cART) on Latent Cytomegalovirus Infection by Aura Temereanca, Luminita Ene, Gratiela Tardei, Camelia Grancea, Cristian L. Achim, Simona Ruta

“…Anti-CMV IgG antibodies were present in 93.7% of participants, with lower levels correlating with longer cART exposure and better immunologic parameters. Patients with immunological treatment success (CD4 > 350 cells/mL) had significantly lower CMV IgG titers compared to those with suboptimal immune response to cART. …”
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Virological Mechanisms in the Coinfection between HIV and HCV by Maria Carla Liberto, Emilia Zicca, Grazia Pavia, Angela Quirino, Nadia Marascio, Carlo Torti, Alfredo Focà

“…Also, HCV might increase immunological defects due to HIV and risk of comorbidities. …”
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The cell autonomous and non-autonomous roles of itaconate in immune response by Chao Chen, Xinjian Li

“…Based on these knowledges, we propose itaconate is a messenger transmitting immunologic signals from myeloid cells to other types of cells during host inflammation and immune defense.…”
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The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep by C. Y. Lee, K. A. Munyard, K. Gregg, J. D. Wetherall, M. J. Stear, D. M. Groth

“…The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions between these forming an interconnecting multilevel relationship. …”
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Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric... by Sinegugu Kholeka Mhlophe, Charlene Clarke, Giovanni Ghielmetti, Giovanni Ghielmetti, Megan Matthews, Tanya Jane Kerr, Michele Ann Miller, Wynand Johan Goosen, Wynand Johan Goosen

“…These findings highlight the value of accurately distinguishing between mycobacterial species in complex samples, especially in high-value animals, to facilitate accurate interpretation of immunological test results and management of aTB.…”
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Disulfidptosis-related immune patterns predict prognosis and characterize the tumor microenvironment in oral squamous cell carcinoma by Xuechen Wu, Boxin Liu, Shi-Zhou Deng, Tengteng Xiong, Lin Dai, Bo Cheng

“…Abstract Background Establishing a prognostic risk model based on immunological and disulfidptosis signatures enables precise prognosis prediction of oral squamous cell carcinoma (OSCC). …”
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Chronic Rhinosinusitis without Nasal Polyps in Asian Patients Shows Mixed Inflammatory Patterns and Neutrophil-Related Disease Severity by Dae Woo Kim, Kyoung Mi Eun, Eun Youn Roh, Sue Shin, Dong-Kyu Kim

“…Chronic rhinosinusitis (CRS) shows heterogeneous immunologic features. Western studies revealed that CRS without nasal polyps (CRSsNP) showed a predominantly type 1 immune response and CRS with nasal polyps (CRSwNP) was characterized by type 2 immune response; however, the detailed immunologic profile of CRSsNP in Asian patients has not been thoroughly investigated. …”
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Global Distribution, Public Health and Clinical Impact of the Protozoan Pathogen Cryptosporidium by Lorenza Putignani, Donato Menichella

“…Principal key indicators of the parasite distribution were associated to environmental (e.g., geographic and temporal clusters, etc.) and host determinants of the infection (e.g., age, immunological status, travels, community behaviours). …”
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Combination of High-Dose Intravenous Immunoglobulins and Itraconozole in Treating Chronic Mycotic Demyelinating Optic Neuritis by Andrew W. Campbell, Ebere C. Anyanwu, Aristo Vojdani

“…This is probably the first report where persistent toxic mold-induced neurological and immunologic disorders were successfully treated with a combination of itraconozole and IVIG.…”
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Human Polymorphisms as Clinical Predictors in Leprosy by Ernesto Prado Montes de Oca

“…Genetic and serum markers in human host can predict leprosy susceptibility per se as well as be useful in classification and/or prediction of clinical variants and immunological responses in leprosy. Adequate and timely assessment of potential risks associated with these 38 host leprosy genes could diminish epidemiological burden and improve life quality of patients with this still prevalent mycobacterial disease.…”
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Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment by Ye. N. Shirokova, K. V. Ivashkin, V. T. Ivashkin

“…Development of new treatment strategy is possible on the basis of assessment of key defects of immunological homeostasis and antigenic targets.…”
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Single-cell transcriptomics unveils multifaceted immune heterogeneity in early-onset versus late-onset cervical cancer by Qian Chen, Dongfeng Deng, Hong Zhu, Shan Li

“…Epithelial cells in EOCC exhibited a notable dual immunological phenotype, characterized by immune-suppressive properties driven by elevated CXCL production, alongside immune-stimulatory features linked to heightened HLA molecule expression. …”
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Role of Serum and Ultrasonometric Markers in the Early Diagnosis of Malignant Transformation of Periductal Liver Fibrosis in Patients with <i>Opisthorchis Felineus</i> Infection by A. Е. Kovshirina, O. S. Fedorova, Yu. V. Kovshirina, V. A. Petrov

“…During the analytical stage, the relationship between the structural features of the liver ac- cording to the results of ultrasound examination (presence of opisthorchiasis-associated periductal fibrosis), clinical parameters, parasitological study data (infection intensity), and changes in biochemical, immunological parameters and tumor markers in patients against the background of O. felineus infection was assessed. …”
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Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value by Xavier Mariette, Gaetane Nocturne, Pascale Chretien, Claire Goulvestre, Paul Cioni, Eric Ballot, Dounia Khelifi-Touhami

“…Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. …”
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Diabetic Neuropathy: A Clinical and Neuropathological Study of 107 Patients by David S. Younger

“…Nerve biopsy revealed the underlying histopathology, including cell and humoral-mediated immunological lesions in the majority of patients. When combined with clinical and laboratory studies, nerve biopsy has the potential to assist in the selection of patients who may benefit from immunomodulatory therapy.…”
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