Suggested Topics within your search.
Suggested Topics within your search.
-
661
CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens
Published 2025-02-01“…The molecule, termed mSA2-CD8h-tILCD32B1, was also successfully expressed in T cells, readily and stably bound biotinylated IgG mAbs in vitro and once decorated with the biotin labeled mAbs, conferred the T cells with high adhesiveness to multiple surface-coated antigens. mSA2-CD8h-tILCD32B1 expressing human T cells decorated ex vivo with a biotin-labeled mAb retained the antibody for hours after accumulation inside breast tumors implanted in immunodeficient recipient mice. Our results collectively suggest that a non-signaling CD32B1 can be used as a versatile scaffold for mAb decoration of T cells. …”
Get full text
Article -
662
Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts
Published 2025-03-01“…Leveraging xenograft tumors derived from patients with unresectable HCCs and a commercially available immunodeficient mouse strain that expresses human GM-CSF and IL-3, we demonstrate a novel but accessible approach for modeling the HCC tumor microenvironment.…”
Get full text
Article -
663
De Novo or inherited: gonosomal mosaicism in hereditary angioedema due to C1 inhibitor deficiency
Published 2025-02-01Get full text
Article