Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…The role of other tissue-resident immune subsets in RCDII is unknown. Here, we characterized CD8 and CD4 T cells in RCDII duodenum at the single-cell level and in situ. …”
Get full text

Bacillus subtilis HGCC-1 improves growth performance and liver health via regulating gut microbiota in golden pompano by Ming Li, Hui Liang, Jian Zhang, Jie Chen, Shichang Xu, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…Abstract Probiotics as green inputs have been reported to regulate metabolism and immunity of fish. However, the mechanisms by which probiotics improve growth and health of fish are unclear. …”
Get full text

MicroRNA Expression in Cutaneous Lupus: A New Window to Understand Its Pathogenesis by Silvia Méndez-Flores, Janette Furuzawa-Carballeda, Gabriela Hernández-Molina, Gustavo Ramírez-Martinez, Nora E. Regino-Zamarripa, Blanca Ortiz-Quintero, Luis Jiménez-Alvarez, Alfredo Cruz-Lagunas, Joaquín Zúñiga

“…It was to assess the levels of a selected panel of circulating miRNAs that could be involved in the regulation of the immune response, inflammation, and fibrosis in cutaneous lupus. …”
Get full text

A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Abstract Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment. …”
Get full text

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group by Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

Get full text

Dairy cows' responses to 2 separation methods after 3 months of cow-calf contact by Anina Vogt, Susanne Waiblinger, Rupert Palme, Uta König von Borstel, Kerstin Barth

“…Fecal and blood samples were collected twice per week from day −1 until +23 relative to separation start for analysis of fecal cortisol metabolites and the immune response. Milk yield in the parlor was continuously recorded. …”
Get full text

Outcomes of Idecabtagene Vicleucel Therapy in Patients with Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience by Aaron Trando, Farid Ghamsari, Philip Yeung, Caitlin Costello, Ila Saunders, Ah-Reum Jeong

“…The incidence of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome incidence was 92% and 12%, respectively. …”
Get full text

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“… Background: Persistent human papillomavirus (HPV) infection is a necessary cause for development of cervical precancerous lesions and cervical cancer, however, only a small percentage of women progress to cervical cancer. The local immune response, determined, among other factors, by Human Leucocyte Antigen (HLA) genes, is thought to be significant. …”
Get full text

Combination of garlic - shatterstone herb powder to control Streptococcus agalactiae infection in tilapia by Ririn Nurul Fauziah, Dinamella Wahjuningrum, , Sukenda, , Ranta

“…In addition, A. sativum-P. niruri suplemented in feed was also able to enhance the immune response by increasing phagocytic activity.   …”
Get full text

Environmental exposures associated with atopy in a rural community in Gwanda district, Zimbabwe: a cross-sectional study by Vuyelwa Ndlovu, Vuyelwa Ndlovu, Moses Chimbari, Pisirai Ndarukwa, Pisirai Ndarukwa, Elopy Sibanda, Elopy Sibanda

Get full text

A novel ready-to-use loop-mediated isothermal amplification (LAMP) method for detection of Burkholderia mallei and B. pseudomallei by Mitsuru Nakase, Jeewan Thapa, Vanaabaatar Batbaatar, Ochirbat Khurtsbaatar, Batchuluun Enkhtuul, Jugderkhorloo Unenbat, Baasansuren Lkham, Sachiho Fujita, Ai Koshikawa, Apichai Tuanyok, Vannarat Saechan, Hideaki Higashi, Kyoko Hayashida, Yasuhiko Suzuki, Chie Nakajima, Takashi Kimura

Get full text

Hubungan Diare dengan Status Gizi Balita di Kelurahan Lubuk Buaya Kecamatan Koto Tangah Kota Padang by Alania Rosari, Eka Agustia Rini, Masrul Masrul

“…Malnutrition may increase the risk of infectious disease because the immune system is decreased. Otherwise, infectious disease can also affect the nutritional status because of decreased food intake, malabsorption, and increased body catabolism. …”
Get full text

Relationship Between Short‐Term Outcomes and PD‐L1 Expression Based on Combined Positive Score and Tumor Proportion Score in Recurrent or Metastatic Head and Neck Cancers Treated W... by Akihiro Ohara, Taisuke Mori, Mai Itoyama, Kazuki Yokoyama, Shun Yamamoto, Ken Kato, Yoshitaka Honma

“…ABSTRACT Background PD‐L1 expression in tumors and immune cells is a biomarker for the efficacy of anti‐PD‐1 antibody (APA) therapy across diverse cancers. …”
Get full text

P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…IL-1β/IL-1R signaling is crucial for P2Y2R-mediated protective immune response in an experimental model of cutaneous leishmaniasis.…”
Get full text

The gene Sr38 for bread wheat breeding in Western Siberia by E. S. Skolotneva, V. N. Kelbin, V. P. Shamanin, N. I. Boyko, V. A. Aparina, E. A. Salina

“…Present-day wheat breeding for immunity exploits extensively closely related species from the family Triticeae as gene donors. …”
Get full text

Magnitude of opportunistic infections and associated factors among HIV-infected individuals attending care and treatment clinics in Dar es Salaam, Tanzania: a hospital-based cross-... by Agricola Joachim, Doreen Kamori, Mtebe Majigo, Doris Andrew Njelekela, Rogath Kishimba, Mololo Noah

“…Promptly implementing the test-and-treat protocol while an individual’s immunity is still strong and timely screening for OI are critical.…”
Get full text

Ethnoracial disparities in childhood growth trajectories in Brazil: a longitudinal nationwide study of four million children by Helena Benes Matos da Silva, Rita de Cássia Ribeiro-Silva, Juliana Freitas de Mello e Silva, Irina Chis Ster, Poliana Rebouças, Emanuelle Goes, Maria Yury Ichihara, Andrêa Ferreira, Julia M. Pescarini, Rosemeire Leovigildo Fiaccone, Enny S. Paixão, Maurício L. Barreto

Get full text

Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression by Yu-Fei Cao, Hui Wang, Yong Sun, Bei-Bei Tong, Wen-Qi Shi, Liu Peng, Yi-Meng Zhang, Yu-Qiu Wu, Teng Fu, Hua-Yan Zou, Kai Zhang, Li-Yan Xu, En-Min Li

Get full text

Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial by Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

“…This anti-inflammatory potential has prompted interest in exploring the MedDiet’s role in immune-mediated diseases, including psoriasis. Observational studies have indicated potential benefits, such as reductions in the Psoriasis Area and Severity Index. …”
Get full text

Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…After a marathon, changes in biomarkers suggesting pathological events in certain organ systems such as cardiovascular, renal, gastrointestinal, liver, hematological, immune, musculoskeletal, central nervous, and endocrine systems can often be observed. …”
Get full text