Prior Anticoagulation and Risk of Hemorrhagic Transformation in Acute Stroke: A Post Hoc Analysis of the PRODAST Study by Gerrit M. Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Martin Grond, Jens D. Rollnik, Lars Marquardt, Andrea Kraft, Eckhard Schlemm, Carsten Eggers, Christoph C. Eschenfelder, Christian Weimar, Hans‐Christoph Diener

“…These findings were confirmed using sensitivity analyses accounting for thrombolysis and mechanical thrombectomy, as well as timing of brain imaging. Antiplatelet therapy had hardly any association with the end points compared with no antithrombotic pretreatment. …”
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Clinical features and prognostic predictors of C. Psittaci Pneumonia: a systematic review and individual patient meta-analysis by Qingqing Jia, Jibo Sun, Dongguang Wang, Jiao Xu, Xiu Li, Shijie Zhang, Lian Wang, Sitong Liu, Xiang Tong, Hong Fan

“…Symptoms including dyspnea (aOR 4.88; 95% CI 3.19–7.46; P < 0.001), neuropsychiatric symptoms (aOR 3.58; 95% CI 2.05–6.28; P < 0.001), gastrointestinal symptoms (aOR 1.76; 95% CI 1.10–2.80; P = 0.018), or the presence of multilobar infiltrates on imaging (aOR 3.27; 95% CI 2.11–5.06; P < 0.001) upon admission frequently serve as indicators of severe pneumonia. …”
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Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center by Olivier Hugli, Jean-Yves Meuwly, Noémie Boillat-Blanco, Pierre-Nicolas Carron, Siméon Schaad, Thomas Brahier, Mary-Anne Hartley, Jean-Baptiste Cordonnier, Luca Bosso, Tanguy Espejo, Olivier Pantet

“…This study evaluates the diagnostic performance of lung ultrasound (LUS), an affordable, consumable-free point-of-care tool, for COVID-19 screening.Design, setting and participants This prospective observational cohort included adults presenting with cough and/or dyspnoea at a SARS-CoV-2 screening centre of Lausanne University Hospital between 31 March and 8 May 2020.Interventions Investigators recorded standardised LUS images and videos in 10 lung zones per patient. Two blinded independent experts reviewed LUS recording and classified abnormal findings according to prespecified criteria to investigate their predictive value to diagnose SARS-CoV-2 infection according to PCR on nasopharyngeal swabs (COVID-19 positive vs COVID-19 negative).Primary and secondary outcome measures We finally combined LUS and clinical findings to derive a multivariate logistic regression diagnostic score.Results Of 134 included patients, 23% (n=30/134) were COVID-19 positive and 77% (n=103/134) were COVID-19 negative; 85%, (n=114/134) cases were previously healthy healthcare workers presenting within 2–5 days of symptom onset (IQR). …”
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Nerve Enlargement in Patients with INF2 Variants Causing Peripheral Neuropathy and Focal Segmental Glomerulosclerosis by Quynh Tran Thuy Huong, Linh Tran Nguyen Truc, Hiroko Ueda, Kenji Fukui, Koichiro Higasa, Yoshinori Sato, Shinichi Takeda, Motoshi Hattori, Hiroyasu Tsukaguchi

“…<b>Methods</b>: To characterize the peripheral nerve phenotype of INF2-related CMT, we studied the clinical course, imaging, histology, and germline genetic variants in two unrelated CMT-DIE patients. …”
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Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews by Keith Wilson, Nigel Westwood, Catherine Wloch, Pauline Harrington, Luke J Rogers, Judith Tanner, Gavin Murphy, Colin S Brown, Jeremy Dearling, Ricky Vaja, Melissa Rochon, Lyn Brierley Jones

“…All six interviewees’ preference was for digital approaches using images. Survey respondents were least likely (50%) to reply to questionnaires that required software to be downloaded and installed. …”
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Sagittal Inclination Angle of the Graft Affects Graft Maturity and Knee Stability After Anterior Cruciate Ligament Reconstruction by Ming Li, Fangang Meng, Dianbo Long, Dorje Wencheng, Yanlin Zhong, Yan Kang, Peihui Wu, Aishan He

“…Using magnetic resonance imaging, graft maturity was evaluated as the mean signal‐to‐noise quotient (SNQ) measured in three regions. …”
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Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms by Yongjae Hong, Geon Ko, Yeong-Jae Jeon, Hyeon-Man Baek, Juni Lee, Donghun Lee, Jieun Park, Jaehong Kim, Keun-A Chang

“…Infarct size was assessed using a 2,3,5-triphenyl tetrazolium chloride (TTC) staining procedure alongside magnetic resonance imaging (MRI). Neuroprotective metabolites including inositol (Ins), glycerophosphocholine+phosphocholine (GPc+ PCh), N-acetylaspartate+N-acetylaspartylglutamate (NAA+NAAG), creatine + phosphocreatine (Cr+PCr), and glutamine+glutamate (Glx) were analyzed via magnetic resonance spectroscopy (MRS). …”
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Synthesis and Characterization of Modified Kaolin-Bentonite Composites for Enhanced Fluoride Removal from Drinking Water by Ebenezer Annan, Emmanuel Nyankson, Benjamin Agyei-Tuffour, Stephen Kofi Armah, George Nkrumah-Buandoh, Joanna Aba Modupeh Hodasi, Michael Oteng-Peprah

“…The results showed that the BET surface areas for the granules were 10 m2/g and 3 m2/g for KBNPs and KB, respectively. The SEM images for the adsorbents before and after adsorption confirm the plate-like morphology of kaolin and bentonite. …”
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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…With continued cognitive decline, magnetic resonance imaging of the head revealed an increased number of lesions with T. gondii-associated ring-enhancing lesions. …”
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Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway by Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao

“…Syt1 is highly expressed in cardiomyocytes and has been used as an extracellular molecular probe for SPECT imaging of cardiac cell death in acute myocardial infarction. …”
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Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality by Marianna Zahurak, Ravi Varadhan, Ilias Christodoulou, Ruyan Rahnama, Jun Choe, Huilin Yang, Monika Kizerwetter, Christian Guaraca, Natalie Jordan Holl, Stamatia C Vorri, Megan Zinsky, Danielle G Jones, Nikol Garcia Espinoza, Yun-Huai Kuo, Jamie B. Spangler, Challice L. Bonifant

“…The resulting CAR-NK cell panel was studied with in vitro binding, activation, and cytotoxicity studies and in mouse xenograft models.Results 26292 and 7G3 CARs of variable CD123 binding affinities were highly expressed in NK cells and conferred antigen-specific activation in vitro. High-resolution imaging demonstrated greater clustering of high-affinity 7G3 CAR-NK cells and consequent AML target cell death in a short-term time lapse. …”
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Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration. …”
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Delayed facial nerve decompression for severe refractory cases of Bell’s palsy: a 25-year experience by Ilyes Berania, Mohamed Awad, Issam Saliba, Jean-Jacques Dufour, Marc-Elie Nader

“…Electroneuronography, electromyography and imaging results were assessed when available. Results Eighteen patients had surgery between 21 and 60 days after onset of BP (group I), and 18 patients had surgery more than 60 days after onset of symptoms (group II). …”
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FEASTS: Radial Distribution of H i Surface Densities Down to 0.01 M⊙ pc−2 of 35 Nearby Galaxies by Jing Wang, Dong Yang, Xuchen Lin, Qifeng Huang, Zhijie Qu, Hsiao-wen Chen, Hong Guo, Luis C. Ho, Peng Jiang, Zezhong Liang, Céline Péroux, Lister Staveley-Smith, Simon Weng

“…We present the H i surface density (Σ _H _i ) radial distributions based on total-power H i images obtained by FAST in the FEASTS program, for 35 galaxies with inclinations lower than 72°. …”
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Metabolic dysfunction-associated fatty liver disease and risk of nephrolithiasis: a sizeable cross-sectional study by Shengqi Zheng, Tianchi Hua, Guicao Yin, Wei Zhang, Xiaoxiang Wang, Lezhong Qi, Xiayong Jing, Qibing Fan, Xiaoping Yu, Yifan Li

“…Based on ultrasound examination, participants were divided into MAFLD and non-MAFLD groups, and the severity of liver steatosis was determined based on ultrasound images. The relationship between MAFLD and nephrolithiasis was analyzed using a multivariate logistic regression model and subgroup analysis was performed.ResultsThe proportion of participants with MAFLD was significantly higher in the nephrolithiasis group compared to the non-nephrolithiasis group (47.70% vs. 30.45%, P &lt; 0.001). …”
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Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis by Işıl Peker, Hacer Eroğlu İçli, Belgin Mutluay, Burcu Yüksel, Zeynep Özdemir, Mesrure Köseoğlu, Aysu Şen, Dilek Ataklı, Aysun Soysal, Musa Öztürk

“…A PATH analysis showed CSF CXCL13 was significantly associated with new T2 hyperintense lesions on brain magnetic resonance imaging (<i>p</i> < 0.001), and baseline serum CCL11 levels were associated with EDSS (<i>p</i> = 0.030), implying its potential role in indicating neurodegenerative processes and possible progression risk. …”
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Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator’s Consortium Registry Analysis by Margaret Stalker, MD, Connor B. Grady, MPH, Alex Watts, MS, Wei-Ting Hwang, PhD, Krishna Chandrasekhara, MS, Fangdi Sun, MD, Geoffrey Liu, MD, Devalben Patel, MD, Jorge Nieva, MD, Amanda Herrmann, MD, Kristen Marrone, MD, Vincent K. Lam, MD, Vamsidhar Velcheti, MD, Stephen V. Liu, MD, Gabriela Liliana Bravo Montenegro, MD, William Tompkins, MD, Tejas Patil, MD, Jared Weiss, MD, Kelsey Leigh Miller, MD, William Schwartzman, MD, Jonathan E. Dowell, MD, Khvaramze Shaverdashvili, MD, PhD, Liza Villaruz, MD, Amanda Cass, PharmD, Wade Iams, MD, Dara Aisner, MD, PhD, Charu Aggarwal, MD, MD, D. Ross Camidge, MD, PhD, Lova Sun, MD, Melina E. Marmarelis, MD

“…The ongoing risk of developing BM, together with the associated survival detriment, argues for routine surveillance of the brain through magnetic resonance imaging for patients with EGFRm NSCLC, which is not currently included in the guidelines.…”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Then the data on demographics, clinical symptoms, imaging characteristics, and laboratory findings were collected. …”
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Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

“…Early response was assessed using magnetic resonance imaging (MRI) after two cycles of treatment. Patients showing poor response, as defined by RECIST 1.1, could opt to receive additional pyrotinib or continue standard therapy. …”
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Transforaminal Endoscopic Lumbar Discectomy versus Coblation Nucleoplasty Combined with Collagenase Chemonucleolysis for Lumbar Disc Herniation with Grade I Degenerative Spondyloli... by Yuyu Guo, Liuhu Han, Tingting Li, Bingbing Xu, Penghui Ke, Jun Hu, Rongyi Zhang, Yan Guo, Long Zhao, Likui Wang

“…The surgical efficacy was evaluated according to the visual analogue scale (VAS), oswestry disability index (ODI), quality of recovery-15 (QoR-15), and modified MacNab criteria. Imaging findings including lumbar lordosis (LL), segmental lordosis angle (SL), slip percentage (SP), and disc height (DH) were compared between the two groups pre-operation and at the last follow-up. …”
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