Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells by Rosa E. Hansen, Mieko Otsu, Ineke Braakman, Jakob R. Winther

“…The results show that while the global thiol-disulfide state is affected to some extent by the differentiation, steady-state levels of glutathionylated protein thiols are less than 0.3% of the total protein cysteines, even in fully differentiated cells, and the overall protein redox state is not affected until late in differentiation, when large-scale IgM production is ongoing. A general expansion of the ER does not affect global protein redox status until an extensive production of cargo proteins has started.…”
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Liver Infarction in a Patient with HELLP and Probable Anti-phospholipid Syndrome by Cihan Kaya, Hüseyin Cengiz, Murat Ekin, Ammar Kanawati, Levent Yaşar

“…Further, laboratory parameters defined an elevated Cardiolipin IgM antibody (11.59 U/ml). She had a diagnosis of HELLP and probable anti-phospholipid syndrome due to these findings. …”
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CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. by Gina L Griffith, Kawthar Machmach, Ningbo Jian, Dohoon Kim, Margaret C Costanzo, Matthew Creegan, Isabella Swafford, Gautam Kundu, Lauren Yum, Jessica S Bolton, Lauren Smith, Bonnie M Slike, Elke S Bergmann-Leitner, Rasmi Thomas, Nelson L Michael, Julie A Ake, Leigh Anne Eller, Merlin L Robb, Samantha M Townsley, Shelly J Krebs, Dominic Paquin-Proulx, RV217 Study Group

“…In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies.…”
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Immunological and Molecular Method for the Diagnosis of Human Bocavirus in Patients with Respiratory Infections in Mosul, Iraq by Anmar A. AlTaie, Noor Raad Abdulghany, Muhammad Abdul-Ghani Muhammad, Mohammad M. Salih, Iman Mutasher Aufi

“…Results: Out of 70 samples, the prevalence rate of immunoglobulin (Ig)M antibodies was 37 (53%), IgG was 33 (47%), and viral DNA for HBoV was 24 (34%), respectively. …”
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Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 by Adriana Martinez-Cuazitl, Monica M. Mata-Miranda, Miguel Sanchez-Brito, Daniel Valencia-Trujillo, Amanda M. Avila-Trejo, Raul J. Delgado-Macuil, Consuelo Atriano-Colorado, Francisco Garibay-Gonzalez, Virginia Sanchez-Monroy, Gustavo J. Vazquez-Zapien

“…Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19.…”
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Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia by Shinsaku Imashuku, Naoko Kudo, Katsushige Takagishi, Katsuyasu Saigo

“…Both patients were diagnosed with primary CAD, with continuously high cold agglutinin titers (1 : >8,192 and 1 : 16,834, resp.), monoclonal IgM-kappa light chains, and no underlying disease. …”
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A Rare but Fascinating Disorder: Case Collection of Patients with Schnitzler Syndrome by Maaman Bashir, Brittany Bettendorf, Richard Hariman

“…Schnitzler syndrome is a rare disorder characterized by a chronic urticarial rash and monoclonal gammopathy (IgM in more than 90% of the cases). It is difficult to distinguish from other neutrophilic urticarial dermatoses, and diagnosis is based on the Strasbourg criteria. …”
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Primera parte. Hombre de 45 años con neumonía grave, infección diseminada por citomegalovirus y agammaglobulinemia by Mónica Fernandes Pineda, Andrés F. Zea-Vera

“…Los valores de las inmunoglobulinas fueron: IgA < 0,13, IgG < 3 e IgM < 0,25 g/L. La biopsia de médula ósea reveló un aumento del 80 % en el número de células, sin alteraciones morfológicas. …”
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Neuropsychiatric Disorder Associated with Group G Streptococcus Infection by Rie Okumura, Sawako Yamazaki, Tsukasa Ohashi, Shinichi Magara, Jun Tohyama, Hiroshi Sakuma, Masaharu Hayashi, Akihiko Saitoh

“…We report a case of Streptococcus dysgalactiae subspecies equisimilis (group G Streptococcus) (GGS) infection associated with involuntary movements, complex tics, and emotional lability in an 11-year-old Japanese girl. Serum IgM and IgG antibodies to lysoganglioside were positive, and she responded rapidly to intravenous immunoglobulin treatment. …”
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A Case of Undetected Neuroborreliosis in a 75-Year-Old Chinese Male by Jenny Lamichhane, Rohail Haider, Michael Bekkerman, Sean Tilford, Shireen Hijaz, Bikash Bhattarai, Rajanish Bobde

“…It was only late in the course of his treatment that blood titers and cerebrospinal fluid analysis were positive for Lyme IgG and IgM. He was treated with intravenous doxycycline and prescribed oral doxycycline on discharge, resulting in a full recovery. …”
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A Curious Case of Pseudothrombocytopenia due to In Vitro Agglutination by Le Zhong, Juskaran Chadha, Ali Ameri

“…The EDTA-dependent mechanism of PTCP occurs due to a conformational change of platelet surface glycoprotein IIb/IIIa (GPIIb/IIIa) caused by EDTA, which allows natural IgM or IgG auto-antibodies to bind to GPIIb/IIIa, leading to platelet agglutination. …”
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Bing and Neel Syndrome by S. Jennane, K. Doghmi, E. M. Mahtat, N. Messaoudi, B. Varet, M. Mikdame

“…The diagnosis was suspected on MRI and confirmed by the detection in the CSF of a monoclonal IgM similar to the one found in the plasma. A quite good partial remission has been obtained after one course of RDHAP (rituximab, dexamethasone, cytarabine, and cisplatin) and 3 courses of RDHOx (rituximab, dexamethasone, cytarabine, and oxaliplatin), in addition to ten intrahectal chemotherapy injections. …”
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Clinical Features and Severity of Leptospirosis Cases Reported in the Hawke’s Bay Region of New Zealand by Paul Sellors, Rebecca F. Watson, Rachel Bate, Gemma L. Bentham, Kathryn Haigh

“…Inclusion criteria were IgM positivity and diagnosis confirmed with either polymerase chain reaction (PCR) or microscopic agglutination test (MAT). …”
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ELISA-Based Measurement of Antibody Responses and PCR-Based Detection Profiles Can Distinguish between Active Infection and Early Clearance of Borrelia burgdorferi by John J. Lazarus, Akisha L. McCarter, Kari Neifer-Sadhwani, R. Mark Wooten

“…Mice receiving even minimal doses of live B. burgdorferi produced significantly more B. burgdorferi-specific IgM and IgG than groups receiving large inocula of heat-killed bacteria. …”
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Hantavirus pulmonary syndrome in Santa Cruz, Bolivia: outbreak investigation and antibody prevalence study. by Joel M Montgomery, Patrick J Blair, Darin S Carroll, James N Mills, Alberto Gianella, Naomi Iihoshi, Ana M Briggiler, Vidal Felices, Milagros Salazar, James G Olson, Raisa A Glabman, Daniel G Bausch

“…Four other persons living on the ranch were IgM antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. …”
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CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type by Alexandra Papoudou-Bai, Leonidas Marinos, Amalia Vassou, Eleni Kapsali, Panagiotis Kanavaros

“…Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. …”
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Acute Transverse Myelitis (Ascending Myelitis) as the Initial Manifestation of Japanese Encephalitis: A Rare Presentation by Varshney Ankur Nandan, Kumar Nilesh, Behera Dibyaranjan, Tiwari Ashutosh, Anand Ravi, Anand Arvind

“…Spinal screening showed abnormal cord intensities in entire cord with gross edema in cervical and conus regions. He had elevated IgM titres against JE virus in cerebrospinal fluid. …”
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Unusual Paraneoplastic Presentation of Cholangiocarcinoma by Aman Opneja, Sonia Mahajan, Sargam Kapoor, Shanthi Marur, Steve Hoseong Yang, Rebecca Manno

“…Immunofluorescence revealed IgM positive cytoid bodies scattered along the epidermal basement membrane zone. …”
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新生儿无症状轮状病毒感染的研究

“…所有新生儿感染的轮状病毒,病毒核酸电泳型均为同一模式,与当年婴幼儿腹泻病孩所分出的轮状病毒流行优势株,其电泳图谱完全重叠。32份脐血中仅1份轮状病毒特异性IgM抗体阳性。此外,用PAGE及阻断ELISA法证实,ELISA法检测无症状新生儿粪便的轮状病毒时,具有较高的假阳性(24.8％)。…”
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Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood by Sylvie Amu, Mikael Brisslert

“…CD25-expressing B cells express a functional IL-2 receptor and high levels of CC-chemokine receptors and spontaneously produce antibodies of IgG and IgM subclass. Conclusions. CD25 expression is a common denominator of a specific immunomodulatory B-cell subset ready to proliferate upon IL-2 stimulation, possibly ready to migrate and home into the peripheral tissue for further differentiation/action.…”
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