Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males by Ming Liao, Lirong Huang, Yan Mao, Yonghua Jiang, Ziting Yao, Xinggu Lin, Zheng Lu, Chunlei Wu, Xue Qin, Haiying Zhang, Zengnan Mo

“…Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile.…”
Get full text

Dermatological Disorders following Liver Transplantation: An Update by Dipesh Kumar Yadav, Xue li Bai, Tingbo Liang

“…Additionally, the incidence of IgE-mediated food allergies develops in 12.2% of LT patients and may present as life-threatening conditions such as urticaria and/or angioedema and hypersensitivity. …”
Get full text

miR-224-5p Attenuates Allergic Responses in Mice with Allergic Rhinitis by Modulating the Th1/Th2 Response by Yuxiao Li, Ran An, Mingjin Wu, Jiayan He, Xiaoguang He

“…RT-qPCR was used to determine the level of miR-224-5p; western blot analysis was used to determine GATA3; ELISA was used to determine the levels of OVA-specific IgE, IFN-γ, IL-4, IL-5, and IL-13; flow cytometry was used to determine the differentiation of Th1 and Th2 cells; and HE and PAS staining was used to observe the histopathological alterations in the mouse nasal mucosa and spleen. …”
Get full text

Mechanisms of reduced sensitization by extensive hydrolysis of milk protein concentrate: Impact on the immune response of Th1/Th2 and Treg/Th17 cells in mice by Qiang Cui, Jianjun Cheng, Mingruo Guo

“…The results demonstrated that the serum levels of the specific IgE, IgG, and IgG1 antibodies in the EMPH group (one-step alcalase-protamex [O-AX] and two-step alcalase-protamex [T-AX]) were significantly decreased (P < 0.01). …”
Get full text

Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy by Urszula Grzybowska-Chlebowczyk, Halina Woś, Aleksander L. Sieroń, Sabina Więcek, Aleksandra Auguściak-Duma, Halina Koryciak-Komarska, Joanna Kasznia-Kocot

“…Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. …”
Get full text

Effects of Earthworm (Pheretima communisima) extract on atopic dermatitis: An in vitro and in vivo study by Yoon-Young Sung, Heung-Joo Yuk, Seung-Hyung Kim, Dong-Seon Kim

“…Oral administration of EWE in AD mouse reduced inflammatory cell accumulation, epidermal hyperplasia, and dermatitis severity in AD skin lesions and thymic stromal lymphopoietin (TSLP) and immunoglobulin (Ig) E concentrations in serum. EWE administration in AD mice also reduced secretion of Interleukin (IL)-4, IL-13, IL-5, and IFN-γ in cultures of isolated splenic cells. …”
Get full text

Nasal food challenge with hen's egg white allergen by Edyta Krzych-Fałta, Andrzej Namysłowski, Sławomir Białek, Monika E. Czerwińska, Konrad Furmańczyk, Aleksandra Tylewicz, Adam Sybilski, Bolesław Samoliński, Oksana Wojas

“…The method consisted in a nasal allergen provocation test carried out with the use of hen's egg white allergen and assessed using the visual analog scale and optical rhinometry as well as by determination of sIgE and tryptase levels in nasal lavage fluid. Results Subjective nasal symptoms and objective evaluations following the application of 100 µg of hen's egg white allergen revealed a moderately positive nasal mucosal response in optical rhinometry tests (ΔE = 0.34 OD). …”
Get full text

Interleukin-1 Receptor-Associated Kinase 4 Deficiency in a Greek Teenager by Panagiota Karananou, Anastasia Alataki, Efimia Papadopoulou-Alataki

“…Her immunological laboratory evaluation revealed low serum IgA and restored in subsequent measurements; normal IgG, IgM, and IgE; and normal serum IgG subclasses. Peripheral blood immunophenotyping by flow cytometry and dihydrorhodamine (DHR) test revealed normal counts. …”
Get full text

Effects of Omalizumab on Serum Levels of Substance P, Calcitonin Gene-Related Peptide, Neuropeptide Y, and Interleukin-31 in Patients with Chronic Spontaneous Urticaria by Cagdas Boyvadoglu, Hasan Ulusal, Seyithan Taysı, Goknur Ozaydin-Yavuz, Ibrahim Halil Yavuz, Pınar Korkmaz, Huseyin Serhat Inaloz

“…This study supports the view that omalizumab does not only affect IgE receptors but also affects mast cells through other mechanisms. …”
Get full text

类风湿关节炎合并干眼症的临床分析

“…【结果】 52例中有干眼自觉症状者12例占23.1%，Schirmer试验阳性者39例(占75.0%)，BUT阳性者48例(占92.3%)，FL阳性者26例(占50.0%)，其中二项以上检查阳性者22例占(42.3%)；IgA、IgM&、IgG、IgE、C3、C4均有不同程度异常;ESR、RF ≥ 25 IU.mL-1 、crp ≥ 5、抗SSA/抗SSB(+)、ANA(+)分别为75%、90.7%、76.9%、9.3%、43.8%。…”
Get full text

Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice by Yiyun Zhang, Jinxing Wang, Qi Zhang, Liling Deng, Siyao Miao, Geng Zhong

“…We found that the number of nasal rubbing and sneezing, the eosinophil (EOS) count in the nasal mucosa, and the serum levels of histamine (HIS), OVA-specific immunoglobulin E (OVA-sIgE) and interleukin-4 (IL-4) were decreased, and the histopathological changes of nasal mucosa were inhibited. …”
Get full text

Cardiogenic Shock due to Kounis Syndrome following Cobra Bite by W. D. D. Priyankara, E. M. Manoj, A. Gunapala, A. G. R. M. A. Ranaweera, K. S. Vithanage, M. Sivasubramanium, E. Snajeeva

“…Serum Troponin was 10 ng/ml (control= <0.5). Serum IgE levels were significantly high (19155IU/ml, baseline 100). 2-Dimensional echocardiogram showed anterior and apical-septal hypokinesia with left ventricular ejection fraction of 30-35%. …”
Get full text

ALLERGIC RHINITICAL THERAPY WITH ACUPUNCTURE, LEGUNDI AND TEMULAWAK HERBS by Maya Septriana, Novita Purnamasari, Herra Studiawan

“…Background: Allergic rhinitis is an inflammatory disease of the nasal mucosa mediated by IgE (immunoglobulin E) with the main mediator histamine. …”
Get full text

Modification of Cɛ mRNA Expression by EBV-Encoded Latent Membrane Protein 1 by Kazuhiko Hanashiro, Shigeto Ohta, Masanori Sunagawa, Mariko Nakamura, Mikio Suzuki, Tadayoshi Kosugi

“…Cɛ mRNA expression in IgE-producing cells are modulated by LMP1, which might depend on the differentiation status of B cells upon exposure to allergen.…”
Get full text

A novel murine model of late-phase reaction of immediate hypersensitivity by S. Facincone, A. L. Pereira De Siqueira, S. Jancar, M. Russo, J. A. Marzagão Barbuto, M. Mariano

“…High levels of ovalbuminspecific IgG1 but not of IgE were detected in the serum of these animals. …”
Get full text

12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens by Din L. Lin, Kevin M. Magnaye, Cara E. Porsche, Sophia R. Levan, Elze Rackaityte, Mustafa Özçam, Susan V. Lynch

“…In primary immune cell coculture assays involving peanut allergen stimulation, 12,13-diHOME promotes both IL-1β and IL-6 production, memory B cell expansion, and increased IgE production. Exposure to 12,13-diHOME also induces macrophage chromatin remodeling, specifically diminishing access to interferon-stimulated response elements resulting in reduced interferon-regulated gene expression upon bacterial lipopolysaccharide stimulation. …”
Get full text

Purification and immunoglobulin E epitopes identification of low molecular weight glutenin: an allergen in Chinese wheat by Yanbo Wang, Yihang Tong, Jinru Zhou, Dong Yang, Linglin Fu

“…In addition, 8 peptides were predicted efficiently by 5 immunological tools, among which five peptides showed significant immunoglobulin E (IgE) binding abilities. Two specific epitopes were found to be in the non-conserved region of the amino acid sequence of LMW-GS, which was speculated to be the specific epitope of Chinese wheat. …”
Get full text

Comprehensive review of pollen-food allergy syndrome: Pathogenesis, epidemiology, and treatment approaches by Yukinori Kato, Taiyo Morikawa, Shigeharu Fujieda

“…In PFAS pathogenesis, when food containing protein antigens (pan-allergens) with high homology to pollen antigens is ingested, mast cells bound to pollen antigen-specific IgE distributed in the oral mucosa cross-react with the food antigen, causing a local type I allergic reaction. …”
Get full text

Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice by E. Hattinger, S. Scheiblhofer, E. Roesler, T. Thalhamer, J. Thalhamer, R. Weiss

“…Vaccination efficiently suppressed TH2 cytokines, IgE responses, and lung eosinophilia. Protection was maintained after repeated exposure to aerosolized allergen and no TH1 associated pathology was observed. …”
Get full text

Predicting the effectiveness of omalizumab in patients with refractory chronic rhinosinusitis with nasal polyps comorbid with asthma based on inflammatory biomarkers by Yutong Sima, MD, Ming Zheng, MD, Yan Zhao, PhD, Siqi Ge, PhD, Chengyao Liu, MD, Ping Wang, BS, Xiangdong Wang, MD, PhD, Luo Zhang, MD, PhD

“…Nasal secretion CXCL-1 (AUC = 0.812), GM-CSF (AUC = 0.813), IgE (AUC = 0.900) and IP-10 (AUC = 0.800) effectively predicted none or less improvement in nasal polyp score. …”
Get full text