Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Knockdown of Cullin 2 (CUL2) stimulated the accumulation of MAF1 protein, attenuated the RNA sensor RIG-I/interferon regulatory factor 3 (IRF3) signaling pathway, and reduced cell apoptosis. …”
Get full text

Research on E-Commerce Platform-Based Personalized Recommendation Algorithm by Zhijun Zhang, Gongwen Xu, Pengfei Zhang

“…Aiming at data sparsity and timeliness in traditional E-commerce collaborative filtering recommendation algorithms, when constructing user-item rating matrix, this paper utilizes the feature that commodities in E-commerce system belong to different levels to fill in nonrated items by calculating RF/IRF of the commodity’s corresponding level. In the recommendation prediction stage, considering timeliness of the recommendation system, time weighted based recommendation prediction formula is adopted to design a personalized recommendation model by integrating level filling method and rating time. …”
Get full text

AN ANALYSIS OF INTERACTIONAL PATTERN BETWEEN TEACHER AND STUDENT IN SMAN 1 CURUP KOTA by Hendi Afriyanto, Alamsyah Harahap, Azwandi Azwandi

“…The data analysis shows that (a) the dominant pattern used in the classroom is complete pattern (IRF) and there are also semi-complete pattern (IR) and incomplete pattern (IF); (b) In the type of acts section, the elicitation is the highest followed by informative and starter in the initiation move,  reply as the highest act in the response move, and in the follow up accept as the highest followed by comment. …”
Get full text

AN ANALYSIS OF INTERACTIONAL PATTERN BETWEEN TEACHER AND STUDENT IN SMAN 1 CURUP KOTA by Hendi Afriyanto, Alamsyah Harahap, Azwandi Azwandi

“…The data analysis shows that (a) the dominant pattern used in the classroom is complete pattern (IRF) and there are also semi-complete pattern (IR) and incomplete pattern (IF); (b) In the type of acts section, the elicitation is the highest followed by informative and starter in the initiation move,  reply as the highest act in the response move, and in the follow up accept as the highest followed by comment. …”
Get full text

Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…Pestiviruses generally counteract the cellular innate immune response by degradation of interferon regulatory factor 3 (IRF3) mediated by the viral N-terminal protease (N^pro). …”
Get full text

Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat by Ahmed A. Elsayed, Ahmed M. Sallam

“…Levels of gene expression of SLC11A1, TLR1, TLR9, SP110, ADORA3, CARD15, IRF3, HMOX1, TKT, RPIA and AMPD were significantly (P < 0.05) up regulated in the infected compared to the non-infected ones. …”
Get full text

From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment by Shengkun Peng, MinHong Cai, Hongyu Kuang, Anqi Lin, Qinghua Ma, Xiaoqin Dai, Peng Luo, Yijun Liu, Guo Zhang, Yifeng Bai

“…Moreover, significant upregulation was observed in inflammatory pathways, specifically those involving IL-1, IL-6, TNF-α, and IRF3/IRF7-mediated immune responses. Clinical cohort analyses demonstrated significant elevations in both cardiac injury biomarkers (NT-proBNP, CK-MB, cTnT) and inflammatory mediators (CRP) following VEGF(R)i administration. …”
Get full text

Evaluation Model and Decision Analysis of Digital Firms Ranked in Forbes’ Top Companies by Fang Chen Kao, Thanh Nhan Dinh, Anh Thi Truc Nguyen

“…This study evaluates the profitability and marketability efficiencies of digital firms ranked in Forbes’ list of top companies by using a two-stage network data envelopment analysis (DEA) model with multiplicative efficiency aggregation under the second-order cone programming (SOCP) and examines the respective impacts of the 1995–2001 dot-com bubble and the 2007–2009 global financial crisis on the companies’ efficiencies by applying impulse response function (IRF) analysis. The data of our 49 sampled companies are derived from the Compustat database. …”
Get full text

Fiscal policy on Peru’s gross domestic product through fiscal multipliers, 2000 – 2022 by Jhunniors Puscan Visalot, Omer Cruz Caro, Alex Javier Sánchez Pantaleón, Einstein Sánchez Bardales, Angelica María Carrasco Rituay, River Chavez Santos

“…Using an SVAR methodology and impulse response analysis (IRF), it was possible to obtain that, after an increase in current spending, GDP initially decreases; and as time passes, it fluctuates and recovers. …”
Get full text

Analysis of the influence internal and external factors on the performance of IDXV30 by Tumpal Samosir, Pardomuan Sihombing

“…The analysis phase is through the Stationarity Test, Optimal Lag Test, VAR Stability Test, Granger Causality Test, Cointegration Test, Impulse Response Function (IRF), and Forecast Error Variance Decomposition (FEVD). …”
Get full text

Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…GQD reduced IL-1β, IL-6, and TNF-α levels in the serum and downregulated TLR4, MyD88, and phosphorylation of IκBα, P65, and IRF3 in the colon tissue from AOM/DSS-induced mice. …”
Get full text

Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected by Mycob... by Elena Giacomini, Maria Elena Remoli, Marta Scandurra, Valérie Gafa, Manuela Pardini, Lanfranco Fattorini, Eliana M. Coccia

“…The analysis of the signalling pathways leading to this selective cytokine expression showed that in monocytes Mtb activates MAPK and NF-κB but is unable to stimulate IRF-3 phosphorylation, a transcription factor required for IL-12p35 and IFN-β gene expression. …”
Get full text

The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…The single-cell RNA sequencing analysis was used to evaluate the expression distribution of the MMP, VEGFA, SPI1, and IRF8 in synovial tissues of patients with osteoarthritis. …”
Get full text

IFN-β production induced by PRRSV is affected by GP3 quantity control and CLND4 interaction by Dexin Li, Xinyu Cui, Yingchao Li, Qin Zhang, Hongyan Gao, Youbo Li, Yanmeng Hou, Hongjie Yuan, Yihong Xiao

“…GP3 also downregulated IFN-β by decreasing the phosphorylation of TBK1 and IRF3. These findings highlight functional differences in GP3 under quantity control, which account for the variations in IFN-β induction during the early and late stages of infection. …”
Get full text

Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…We observed (1) graded μS-PAS usage during PC differentiation, (2) IRF4 and Blimp-1 functioned hierarchically to increase μ abundance as well as μS-PAS usage, and (3) graded μS populations did or did not express Blimp-1. …”
Get full text

CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type by Alexandra Papoudou-Bai, Leonidas Marinos, Amalia Vassou, Eleni Kapsali, Panagiotis Kanavaros

“…Immunohistochemistry revealed that these large cells were positive for CD5, CD20, CD79a, MUM1/IRF4, Bcl6, Bcl2, and cytoplasmic IgM/λ, whereas CD3, CD56, CD23, CD21, CD10, CD30, cyclin D1, CD68, lysozyme, myeloperoxidase, and CD34 were not detected. …”
Get full text

Unraveling the immunomodulatory and metabolic effects of bioactive glass S53P4 on macrophages in vitro by Karoliina Kajander, Nicole Nowak, Negin Vaziri, Pekka K. Vallittu, Terhi J. Heino, Jorma A. Määttä

“…Additionally, BG S53P4-exposed macrophages expressed lower mRNA levels of inflammatory cytokines Il6 and Il1b, as well as demonstrated decreased activation of inflammatory interferon regulatory factor (IRF) and NF-κB pathways and nitrogen oxide secretion in response to LPS. …”
Get full text

The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…It highlights how NPs mitigate macrophage imbalances to alleviate SALI, focusing on key signaling pathways such as PI3K/AKT, TLR4/NF-κB, JAK/STAT, IRF, HIF, NRF2, HMGB1, TREM2, PKM2, and exosome-mediated signaling. …”
Get full text

Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically by Mingming Zhao, Dragana Jankovic, Verena M. Link, Camila Oliveira Silva Souza, Katherine M. Hornick, Oyebola Oyesola, Yasmine Belkaid, Justin Lack, Png Loke

“…IL-4-directed epigenomic remodeling reveals C57BL/6 specific enrichment of NF-κB, IRF, and STAT motifs. Additionally, IL-4-activated C57BL/6 TRMs demonstrate an augmented synergistic response upon in vitro lipopolysaccharide (LPS) exposure, despite naïve BALB/c TRMs displaying a more robust transcriptional response to LPS. …”
Get full text

The PB1 protein of H9N2 influenza A virus inhibits antiviral innate immunity by targeting MAVS for TRIM25-mediated autophagic degradationThe parent data and images support the find... by Jiawei Luo, Yiyuan Lu, Enqi Dai, Nianchun Yin, Ting Wang, Hongxi Qian, Qingrong Jiang, Xin Cao, Chunfeng Wang, Yan Zeng

“…Furthermore, H9N2 PB1 inhibited the phosphorylation of IRF3, IκBα, and TBK1 and the secretion of IFN-β. …”
Get full text