A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Methods Participants were randomized to either: (1) TES: the “Vira” smartphone app (Ksana Health Inc.), informed by behavioral activation and using passive sensing technology to provide behavioral “insights” and target behaviors associated with mental health symptoms, alongside lay-provider coaching, or (2) Control: the Mood Education mobile app (ME), containing static psychoeducational resources designed to target mental health symptoms. …”
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The enigmatic diploid Chenopodium ucrainicum (Chenopodiaceae / Amaranthaceae s. l.): geographical, ecological, and phytosociological patterns as clues to its origin by Shynder O.I., Pashkevych N.A., Kharytonova I.P., Holovko O.V., Mandák B., Mosyakin S.L.

“…This study provides a detailed account of its presently known geographical distribution, ecological preferences, and phytosociological features, plus some further information of its morphology, based on field surveys conducted during 2021–2024 across central and western regions of Ukraine. …”
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The Chinese version of the immediate mood scaler (IMS): a study evaluating its validity, reliability, and responsiveness in patients with MDD in China by Xiongying Chen, Zizhao Feng, Nanxi Li, Le Xiao, Xu Chen, Xuequan Zhu

“…At baseline, data from 368 patients with MDD, including demographic information and scores on the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and IMS, were collected. …”
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Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes by Subin Lee, Alexander Giesen, Dimitrios Mouselimis, Loris Weichsel, Andreas A. Giannopoulos, Max Nunninger, Matthias Renker, Florian André, Norbert Frey, Grigorios Korosoglou

“…The Agatston score, CAD-RADS and high-risk plaque features may provide complementary prognostic information in patients with CCS. A composite CCTA score, derived by these imaging markers may identify high-risk individuals, who may benefit from more intensified treatment and clinical follow-up in future studies.…”
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The association between tobacco and alcohol use and health outcomes in individuals living with diabetes and prediabetes in South Africa: A cross-sectional study by S J Mulder, T Chivese, C O Egbe

“…Research on tobacco and alcohol use and specific health outcomes among adults with prediabetes or type 2 diabetes mellitus (T2DM) could provide valuable information leading to more efficient treatment and management of this disease. …”
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Surface processes and drivers of the snow water stable isotopic composition at Dome C, East Antarctica – a multi-dataset and modelling analysis by I. Ollivier, I. Ollivier, H. C. Steen-Larsen, B. Stenni, L. Arnaud, M. Casado, A. Cauquoin, G. Dreossi, C. Genthon, B. Minster, G. Picard, M. Werner, A. Landais

“…<p>Water stable isotope records in polar ice cores have been largely used to reconstruct past local temperatures and other climatic information such as evaporative source region conditions of the precipitation reaching the ice core sites. …”
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The prevalence and associated disability burden of mental disorders in children and adolescents in China: a systematic analysis of data from the Global Burden of Disease StudyResea... by Wanyue Dong, Yunning Liu, Ruhai Bai, Lei Zhang, Maigeng Zhou

“…Methods: Following the same approach as the Global Burden of Disease Study 2021, we systematically analyze epidemiological and demographic information for mental disorders, and assess the prevalence, disability-adjusted life-years (DALYs), and years lived with disability (YLDs) in the children and adolescents for mental disorders and their ten subtypes across national and provinces in China from 1990 to 2021. …”
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FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

“…Participants will be required to provide written informed consent. The results of this trial will be disseminated through national and international presentations and peer-reviewed publications.Trial registration number The trial was registered at ClinicalTrials.gov on 23 February 2024 (NCT06286709). …”
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The implementation of genome sequencing in rare genetic diseases diagnosis: a pilot study from the Hong Kong genome projectResearch in context by Wai Kei Jacky Lam, Chak Sing Lau, Ho Ming Luk, Lisa Wing Chi Au, Gary C.P. Chan, Will Yap Hang Chan, Shirley Sze Wing Cheng, Timothy Hua Tse Cheng, Li Li Cheung, Yiu Fai Cheung, Josephine Shuk Ching Chong, Annie Tsz Wai Chu, Claudia Ching Yan Chung, Kin Lai Chung, Cheuk Wing Fung, Eva Lai Wah Fung, Yuan Gao, Stephanie Ho, Shirley Pik Ying Hue, Chi-Ho Lee, Tsz Leung Lee, Philip Hei Li, Hei Man Lo, Ivan Fai Man Lo, Herbert Ho Fung Loong, Becky Mingyao Ma, Wei Ma, Shirley Yin Yu Pang, Wai-Kay Seto, Steven Wai Kwan Siu, Ho So, Yuk Him Tam, Wenshu Tang, Rosanna Ming Sum Wong, Desmond Yat Hin Yap, Maggie Lo Yee Yau, Brian Hon Yin Chung, Su-Vui Lo

“…All participants received srGS, while lrGS was applied to a subset to resolve technically challenging regions unclear from srGS and provide phasing information for potential compound heterozygous variants. …”
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AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecogniz... by Raquel M. Zimmerman, Edgar J. Hernandez, Mark Yandell, Martin Tristani-Firouzi, Robert M. Silver, William Grobman, David Haas, George Saade, Jonathan Steller, Nathan R. Blue

“…Results Feature selection identified the 16 most informative variables, which yielded a PGM with good overall performance in the validation cohort (AUC 0.83, 95% CI 0.79–0.87), including among “N of 1” unique scenarios (AUC 0.81, 0.72–0.90). …”
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Intention to vaccinate against COVID-19 and adherence to non-pharmaceutical interventions against COVID-19 prior to the second wave of the pandemic in Uganda: a cross-sectional stu... by Ambrose Talisuna, Solome Okware, Rhoda K Wanyenze, Solomon Tsebeni Wafula, Innocent B Mugume, Benjamin Sensasi, Alexander Chimbaru, Richard Kabanda, Tabley Bakyaita, Jayne Byakika-Tusiime

“…Dissemination of accurate, safe and efficacious information about the vaccines is necessary to enhance vaccine uptake.…”
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Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Acinetobacter baumannii Clinical Isolates in South Africa by Yaw Adjei Anane, Teke Apalata, Sandeep Vasaikar, Grace Emily Okuthe, Sandile Songca

“…Results showed a high level of oxacillinases producing A. baumannii circulating in our study setting, highlighting the need for local molecular surveillance to inform appropriate management and prevention strategies.…”
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Prevalence of depression and its correlates among undergraduate health science students in Mogadishu, Somalia: a cross-sectional study by Bashiru Garba, Samiro Ali Mohamed, Maria Mowlid Mohamed, Hodo Aideed Asowe, Najib Isse Dirie, Yushau Umar, Jamal Hassan Mohamoud, Mohamed Hussein Adam, Jihaan Hassan, Fartun Abdullahi Hassan Orey, Abdullahi Abdirahman Omar, Ibrahim Abdullahi Mohamed, Mohamad Mustaf Ahmed, Samira Abdullahi Moalim

“…However, there is a scarcity of information in this regard in higher education institutions in Somalia. …”
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Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction by Ralf J. Dirschinger, Ralf J. Dirschinger, Alexander Müller, Petra Barthel, Alexander Steger, Michael Dommasch, Axel Bauer, Karl-Ludwig Laugwitz, Georg Schmidt, Daniel Sinnecker, Daniel Sinnecker

“…The aim of this study was to assess whether this post-extrasystolic ST segment and T wave variation (PEST) conveys prognostic information regarding the mortality risk of cardiac patients.MethodsPEST was calculated from 30-min ECGs obtained from 941 survivors of acute myocardial infarction (AMI) as mean difference between the sum of squared voltages from three orthogonal leads (XYZ) of the first (post-extrasystolic) and second (reference) beat after each VPC, in a time window between the limits ϕ1 and ϕ2. …”
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Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modeling by Han Zhang, Jiaxing Dai, Qiuqiao Mu, Xiaojiang Zhao, Ziao Lin, Ziao Lin, Kai Wang, Meng Wang, Meng Wang, Daqiang Sun

“…We also examined differences between high and low-risk groups in terms of pathway enrichment, mutation information, tumor microenvironment(TME), and immunotherapy efficacy. …”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…Subjects completed surveys related to smoking habits and mental health, including the Fagerstrom test for nicotine dependence and Patient-Reported Outcomes Measurement Information System questionnaire, respectively. Patients were provided free nicotine replacement therapy for 4 weeks. …”
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Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control studyResearch in context by Amazigh Mokhtari, El Chérif Ibrahim, Arnaud Gloaguen, Claire-Cécile Barrot, David Cohen, Margot Derouin, Hortense Vachon, Guillaume Charbonnier, Béatrice Loriod, Charles Decraene, Ipek Yalcin, Cynthia Marie-Claire, Bruno Etain, Raoul Belzeaux, Andrée Delahaye-Duriez, Pierre-Eric Lutz

“…Importantly, they also demonstrated that performance progressively increased with the number of molecular datasets considered. Interpretation: Informational gain from multiomic integration had already been documented in other medical fields. …”
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Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis by Alessio Gerussi, Oliver Lester Saldanha, Giorgio Cazzaniga, Damiano Verda, Zunamys I. Carrero, Bastian Engel, Richard Taubert, Francesca Bolis, Laura Cristoferi, Federica Malinverno, Francesca Colapietro, Reha Akpinar, Luca Di Tommaso, Luigi Terracciano, Ana Lleo, Mauro Viganó, Cristina Rigamonti, Daniela Cabibi, Vincenza Calvaruso, Fabio Gibilisco, Nicoló Caldonazzi, Alessandro Valentino, Stefano Ceola, Valentina Canini, Eugenia Nofit, Marco Muselli, Julien Calderaro, Dina Tiniakos, Vincenzo L’Imperio, Fabio Pagni, Nicola Zucchini, Pietro Invernizzi, Marco Carbone, Jakob Nikolas Kather

“…In addition, there is need for quantitative assessment of information embedded in liver biopsies, which are currently evaluated on qualitative or semi-quantitative methods. …”
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Validation of the version 4.5 MAESTRO ozone and NO₂ measurements by P. S. Jeffery, J. R. Drummond, C. T. McElroy, K. A. Walker, J. Zou

“…The version 4.5 retrieval algorithm represents an improvement from previous versions, with changes including updated pressure and temperature input information, an improved algorithm for high-Sun reference spectrum calculation, improved Rayleigh scattering modelling, and the change to a Twomey–Tikhonov inversion algorithm from a Chahine relaxation technique. …”
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Understanding the experiences of young, urban, Indigenous mothers-to-be in British Columbia, Canada by Nicole L. A. Catherine, Jennifer Leason, Namaste Marsden, Brittany Barker, Ange Cullen, Ashley Simpson, Brandi Anne Berry, Erik Mohns, Donna Yung, Yufei Zheng, Harriet MacMillan, Charlotte Waddell

“…Given higher fertility rates, younger overall ages and higher adolescent pregnancy rates, perinatal research is needed—to inform policymaking and programming throughout pregnancy and childhood. …”
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