Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome by Zhuo Liu, Rui-Han Wang, Ke-Hua Wang

“…Abstract Background Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by multiple clinical features, including anovulation, hyperandrogenism, and polycystic ovarian morphology, leading to infertility. …”
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Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome by Xu Boqun, Dai Xiaonan, Cui YuGui, Gao Lingling, Dai Xue, Chao Gao, Diao Feiyang, Liu Jiayin, Li Gao, Mei Li, Yuan Zhang, Xiang Ma

“…Combined with its localization in theca cells, SET may participate in regulating ovarian androgen biosynthesis and the pathophysiology of hyperandrogenism in PCOS.…”
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Two Novel CYP11B1 Gene Mutations in Patients from Two Croatian Families with 11β-Hydroxylase Deficiency by Katja Dumic, Tony Yuen, Zorana Grubic, Vesna Kusec, Ingeborg Barisic, Maria I. New

“…Here, we describe the molecular genetics of two previously reported male siblings in whom diagnosis of 11β-OHD has been established based on their hormonal profiles displaying high levels of 11-deoxycortisol and hyperandrogenism. Both patients are compound heterozygous for a novel p.E67fs (c.199delG) mutation in exon 1 and a p.R448H (c.1343G>A) mutation in exon 8. …”
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Use of complementary and alternative medicine among females with polycystic ovary syndrome in Jordan: a cross-sectional study by Oriana Awwad, Mais Saleh, Ali Alsamydai, Fatma U Afifi, Amal Akour, Renad Abu Tarboosh, Manar Hamdan, Asma Sa’d Basha, Sanaa K Bardaweel

“…Common PCOS signs/symptoms included menses irregularity (81.8%), fatigue (71.6%) and hyperandrogenism (77.6%). Among all participants, 63.2% used CAM with the most common being herbs (60.4%). …”
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Plasma Diaphanous Related Formin 1 Levels Are Associated with Altered Glucose Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Case Control Study by Xing Li, Mingyu Liao, Jiaqing Shao, Weixin Li, Liu Shi, Dong Wang, Juan Ni, Qiuyue Shen, Fan Yang, Guiliang Peng, Ling Zhou, Yuling Zhang, Zheng Sun, Hongting Zheng, Min Long

“…PCOS patients manifested hyperandrogenism, increased luteinizing hormone/follicle-stimulating hormone (LH/FSH), and accumulated body fat and insulin resistance. …”
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Pre-gestational diabetes in a young woman with a pathogenic INSR missense mutation, p.(Met1180Lys) by Emma L Prehn, Mairéad Crowley, David Fennell, Brendan T Kinsley, Kevin Colclough, Maria M Byrne

“…Heterozygous insulin receptor (INSR) mutations cause type A insulin resistance (IR), associated with a phenotype of IR; hyperandrogenism, oligomenorrhoea and acanthosis nigricans in the absence of obesity or lipoatrophy. …”
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Utility of Visceral Adiposity Index and Lipid Accumulation Products to Define Metabolically-Unhealthy Polycystic Ovary Syndrome in Asian Indian Women - A Cross Sectional Study by R. A. Shreenidhi, Reeta Mahey, Monika Rajput, Rohitha Cheluvaraju, Ashish D. Upadhyay, Jai Bhagwan Sharma, Garima Kachhawa, Neerja Bhatla

“…Background: Polycystic ovary syndrome (PCOS) women are at risk of developing diabetes, cardiovascular disease and metabolic syndrome (MetS) due to insulin resistance (IR) and hyperandrogenism (HA). Both visceral adiposity index (VAI) and lipid accumulation product (LAP) are simple outpatient department-based metric tools that have been introduced to screen PCOS women who are metabolically unhealthy and are at risk of development of MetS. …”
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The Hormonal dysregulation and its consequences in Obese Women - overview by Katarzyna Maria Pala, Wiktoria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Maria Golińska, Anna Nowak, Jakub Kurasz, Wiktoria Podlasiewicz, Piotr Dudziak, Wojciech Maj

“…Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects.   …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…After steroidogenic human granulosa-like tumor cell line KGN were exposed to 100 μmol/L DHEA to simulate the hyperandrogen environment of PCOS, and then treated with 5 and 10 μg/mL AS for 24 h, the protein levels of endoplasmic reticulum stress signaling pathway was detected by Western blotting. …”
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