Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis by Ruoyu Wan, Ruohong Wan, Qing Xie, Anshu Hu, Wei Xie, Junjie Chen, Yuhan Liu

“…However, there are numerous challenges, and fully realizing AI’s potential will require overcoming hurdles in algorithm design, data integration, and societal ethics. …”
Get full text

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Still, they face substantial hurdles when applied to the central nervous system (CNS), such as the blood–brain barrier (BBB) and unwanted systemic effects. …”
Get full text

Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Acti... by Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

“…Cell-free therapy using a conditioned medium (CM) of mesenchymal stem cells has been highlighted in the field of regenerative medicine owing to its potent therapeutic effects with lower regulatory hurdles and safety risk. Recently, we demonstrated that a CM of an immortalized stem cell line from human exfoliated deciduous teeth (SHED) has protective effects against a mouse model of ulcer formation via antioxidative and angiogenic activities mediated by HGF and VEGF. …”
Get full text

RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…However, its low immunogenicity has been a hurdle, resulting in the production of minimal anti-RBD antibodies even when combined with alum adjuvant. …”
Get full text

CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics by Young-Kyu Park, Tae-Wook Kang, Su-Jin Baek, Kwon-Il Kim, Seon-Young Kim, Doheon Lee, Yong Sung Kim

“…High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic alterations and genes. The main hurdle in cancer genomics is to identify the real causative mutations or genes out of many candidates from an HGT-based cancer genomic analysis. …”
Get full text

Synthesis and performance analysis of novel SiO2 Janus nanoparticles for enhancing gas foam injection in oil reservoirs by Amir Hossein Saeedi Dehaghani, Reza Gharibshahi, Mohammad Mohammadi

“…Abstract Gas foam injection offers a viable solution to challenges faced in oil reservoirs, yet ensuring optimal foamability and stability remains a pivotal hurdle in practical field operations. This study presents a novel synthesis procedure to create silica (SiO2) Janus nanoparticles (JNPs) and examines their potential to enhance gas foam stability for enhanced oil recovery (EOR) applications. …”
Get full text

Prevalence and level of stress among final-year students at a health science institute in Bangladesh by Md. Jonaied Alam, Mahmudul Islam Khan Pratik, Abid Hasan Khan, Muhammad Shahidul Islam, Muhammad Millat Hossain

“…Abstract Background Final-year students studying in various health science institutes are usually very stressed about their studies so that they can complete their studies without any hurdles. This stress can lead to poor academic and professional results because psychological issues such as anxiety and depression are frequently overlooked and not treated. …”
Get full text

Affective-sexual and gender diversity in Spanish education: a systematic literature review by Delfín Ortega-Sánchez, Esther Sanz de la Cal, Jaime Ibáñez Quintana, Eduardo Encabo-Fernández

“…The sensitivity of the content and its curricular invisibility, along with training deficiencies, lack of academic recognition, and the absence of specific protocols for preventing LGBTIQphobia are identified as the most prominent limitations or hurdles for the comprehensive promotion of education pertaining to affective-sexual and gender diversity across distinct educational stages.DiscussionInstances of discrimination, harassment, and both physical and symbolic violence against non-heteronormative groups, grounded in the sex-gender system and cis-heteronormativity, continue to be recognized by educators. …”
Get full text

Neonatal Intensive Care Unit Apocalypse—Rise of the World Health Organization Priority Pathogens by Apurva Kawdiya, Swati Bhalse, Gaurav Mogra, Kewal K Arora

“…Background: With higher neonatal survival, increasing neonatal intensive care unit (NICU) admissions, and rampant use of antibiotics, highly resistant organisms have become a major hurdle in the path of intact survival of neonates. …”
Get full text

Comparing the Scores of The Functional Movement Screen™ in Individuals with Low Back Pain versus Healthy Individuals: A Systematic Review and Meta-Analysis by Khalid M. Alkhathami, Bijad Alqahtani

“…Patients with LBP had a significantly lower score than the control group regarding FMS™ movement patterns, the deep squat (p <0.01), the hurdle step (p <0.01), the inline lunge (P value <0.01), the active straight leg raise (p <0.01), the trunk stability push-up (p=0.02), and the rotational stability screens (p <0.01)…”
Get full text

Overcoming barriers for investigating nickel-pincer nucleotide cofactor-related enzymes by Jorge L. Nevarez, Aiko Turmo, Santhosh Gatreddi, Swati Gupta, Jian Hu, Robert P. Hausinger

“…LarB, LarC, and LarE are responsible for NPN synthesis, with the cofactor subsequently installed into LarA homologs. Hurdles for investigating the functional properties of such proteins arise from the difficulty of obtaining the active, NPN cofactor-loaded enzymes and in assaying their diverse reactivities. …”
Get full text

Identifying Factors Associated with Barriers in the Number of Antenatal Care Service Visits among Pregnant Women in Rural Parts of Ethiopia by Sali Suleman Hassen, Belete Mulatu Teshale, Lema Abate Adulo

“…Nearly 42% of pregnant mothers did not visit antenatal care services, and only 1% of the mothers attended antenatal care service visits eight times and above. From hurdle Poisson regression model results, women having previous pregnancy complication (AOR = 1.16; P≤0.001); husbands with primary education (AOR = 1.02; P=0.004), secondary education (AOR = 1.117; P≤0.0001), and higher education (AOR = 1.191; P≤0.001); middle wealth index (AOR = 1.08; P=0.006); richer wealth index (AOR = 1.10; P≤0.001); maternal age 35–49 (AOR = 0.690; P≤0.001); being exposed to media access (AOR = 1.745; P=0.019); having distance problem (AOR = 0.75; P=0.013); planned pregnancy (AOR = 1.42; P=0.002); and mothers with primary education (AOR = 1.85; P≤0.001) and secondary (AOR = 2.387; P≤0.001) were statistically associated with barriers in the number of ANC service visits. …”
Get full text

REVIEW ON PROTEIN FOOTPRINTING AS A TOOL IN STRUCTURAL BIOLOGY by Oluwatosin Ogundairo, Oluwatoyin Ayo-Farai, Chinedu Paschal Maduka, Chiamaka Chinaemelum Okongwu, Abdulraheem Olaide Babarinde, Olamide Sodamade

“…Additionally, it discusses challenges associated with the technique, such as data interpretation and accessibility, and proposes future directions for overcoming these hurdles. Protein footprinting stands as a valuable tool in the structural biologist’s arsenal, providing unique perspectives on protein structure and dynamics. …”
Get full text

Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.<h4>Objective</h4>The study explored the utility of interferon-gamma (IFN-γ) inducible protein 10 (IP-10) for diagnosing latent and active M.tb infections among children vaccinated with the Bacille Calmette-Guerin (BCG) vaccine. …”
Get full text

The Antibacterial Effect In Vitro of Honey Derived from Various Danish Flora by Reem Dina Matzen, Julie Zinck Leth-Espensen, Therese Jansson, Dennis Sandris Nielsen, Marianne N. Lund, Steen Matzen

“…We conclude that honeys derived from Danish flora possess antibacterial effect, probably by a hurdle effect of viscosity, osmolality, acidity, bioactive peptides, and most importantly the content of hydrogen peroxide. …”
Get full text

Exploring barriers to rehabilitation for individuals with spinal cord injury: a qualitative study in Iran by Farhad Nosrati Nejad, Mehdi Basakha, Abdurrahman Charkazi, Abdullatif Esmaeili

“…Results The study identified three primary categories of barriers: 1) Personal limiting factors, such as insufficient health literacy and inadequate home adaptations; 2) provider-related, including insufficient expertise, non-professional service delivery, inappropriate facility adaptations, limited service accessibility, and inadequate service provision; and 3) socio-supportive, encompassing companionship needs, financial constraints, insurance limitations, and bureaucratic hurdles. Conclusion The findings of this study highlight a complex interplay of patient, provider, and societal factors that impede access to rehabilitation services for individuals with spinal cord injuries in Golestan province. …”
Get full text

Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…The bioavailability of compounds such as antisense oligonucleotides and siRNAs in humans remains a big hurdle, which will require further improvement of gene-delivery strategies. …”
Get full text

Assessing The Impact of Record Managers Training on Organizational Performance: A Case Study of Kabale University. by Kyasimiire, Sheillah

“…From objective two above, it was found out that there was a lack of basic skills and competencies for handling records, technological hurdles because most of the information is kept in the form of multimedia, insufficient cost the record center cannot provide a good service and without good planning on the budget the record, records management are not specific to a particular file format. …”
Get full text

Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells by K. S. Young, G. R. Hancock, E. C. Fink, A. Zigrossi, B. Flowers, D. A. Cooper, V. T. Nguyen, M. C. Martinez, K. S. Mon, M. Bosland, D. R. Zak, A. P. Runde, M. N. Sharifi, I. Kastrati, D. D. L. Minh, S. Kregel, Sean W. Fanning

“…Abstract Resistance to endocrine therapies remains a major clinical hurdle in breast cancer. Mutations to estrogen receptor alpha (ERα) arise after continued therapeutic pressure. …”
Get full text

Effects of Bioactive Packaging Films Incorporated with Bifidocin A on Microbial Reduction and Quality Parameters of Chill-Stored Spanish Mackerel (Scomberomorus niphonius) Fillets by Guorong Liu, Xue Li, Xu Hao, Chengtao Wang, Baoguo Sun

“…Hence, the bioactive packaging films incorporated with bifidocin A could be a promising hurdle technology and alternative to conventional processes used for improving the safety and quality of chilled mackerel fillets.…”
Get full text