Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens by Tomás Rodrigues, Francisco Antonio Guardiola, Daniela Almeida, Agostinho Antunes

“…Despite challenges such as stability, ecological impacts, and regulatory hurdles, advancements in peptidomimetics and genetic engineering hold significant promise. …”
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Navigating the integration of ChatGPT in UAE’s government sector: challenges and opportunities by Ghada Nabil Goher

“…Originality/value – This study uniquely examines ChatGPT’s role in government, offering insights into communication, efficiency, decision-making, and service offerings. Identifying hurdles enriches understanding of ChatGPT’s practical integration in government.…”
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Embracing E-Court Innovation: Advancing Maslahah Mursalah in Indonesia's Religious Courts by Eti Yusnita, Yuswalina, Muhammad Toriq

“…The findings highlight that while the e-court system largely aligns with existing regulations, hurdles like inadequate network infrastructure and limited public digital literacy persist. …”
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Response of Non-Irrigated Peanut to Multiple Rate Delayed Flumioxazin Applications by Nicholas L. Hurdle, Timothy L. Grey, Juliana de Souza Rodrigues, W. Scott Monfort

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Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes by Sungkyoung Choi, Sunghwan Bae, Taesung Park

“…However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the “large p and small n” problem. …”
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Immunological Approaches and Different Strategies for Vaccine Development Against SARS-COV-2 by Muhammed Babakir-Mina

“…This study gives an update on the current immunological approaches and vaccination strategies for the emerging SARS-COV-2, and discusses the challenges and hurdles to overcome for developing efficacious vaccines against this dangerous pathogen. …”
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Protéger et guérir : la mission du gouvernement et des associations d’aide aux détenues en Angleterre entre 1856 et 1914 by Alice Bonzom

“…In Victorian and Edwardian England, life after release from prison was fraught with hurdles, especially for women. Female criminals had deviated from normative gender-biased ideologies describing woman’s true nature as meek, gentle, modest and shameful; they were stigmatized and ostracized, even after serving their sentences in a local or a convict prison. …”
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Awareness of Healthcare Providers About COVID-19 Vaccinations in Karbala City by Atta Ah. Mousa Al-Sarray, Rasha Haider Shareef

“…It would probably take months to design and manufacture a coronavirus vaccine, which is a significant hurdle. Despite promises from several groups that a corona virus vaccine will be ready soon, achieving so will be challenging in reality. …”
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Conflict-induced displacement in Pakistan: a sociological study of lived experiences of involuntary migration among Afghan immigrants by Kashif Iqbal, Sheng Hongcheng, Hu Liang

“…The finding revealed the challenging legal and administrative hurdles faced by Afghan immigrants, the economic disparities, the complex dynamics of social integration, and accommodation issues within the host community. …”
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A review on topology and control strategies of high-power inverters in large- scale photovoltaic power plants by Amirreza Azizi, Mahdi Akhbari, Saeed Danyali, Zahra Tohidinejad, Mohammadamin Shirkhani

“…This paper aims to delve into the exploration of diverse structural configurations and technical hurdles encountered in high-power multilevel inverter topologies, alongside the associated control systems and modulation techniques tailored for application in large-scale photovoltaic power plants (LS-PV-PP) systems. …”
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How Can Law and Policy Reform Shape Human Resource Strategies in Indonesian State Universities Post-Law No. 20 of 2023? by Siti Mursidah, Cahya Wulandari, Moh Khoiruddin, Muhammad Sayuti Hassan, Ricky Dermawan Fauzi

“…Adjusting organizational structures and enhancing staff competencies remain major hurdles. The novelty of this research lies in its focus on the intersection of legal reform and HR strategies in higher education. …”
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TRIM25: A Global Player of Cell Death Pathways and Promising Target of Tumor-Sensitizing Therapies by Wolfgang Eberhardt, Usman Nasrullah, Josef Pfeilschifter

“…Therapy resistance still constitutes a common hurdle in the treatment of many human cancers and is a major reason for treatment failure and patient relapse, concomitantly with a dismal prognosis. …”
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Genome-editing opportunities to enhance cattle productivity in the tropics by Luiz Sergio de Almeida Camargo, Jorge Fernando Pereira

“…Several strategies have been adopted in an attempt to overcome such hurdles in the tropical regions, but definitive solutions are yet to be implemented. …”
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Leveraging AI-driven nudge theory to enhance hand hygiene compliance: paving the path for future infection control by Samiksha Bhattacharjee, Sudip Bhattacharya

“…However, implementing AI solutions in countries like India faces challenges, including limited resources, resistance to new technologies, and cultural barriers. Despite hurdles, integrating AI-driven nudges with behavioral strategies has the potential to transform hand hygiene practices. …”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Issues such as standardization, regulatory approval, and supply sustainability remain significant hurdles. Overcoming these limitations requires a concerted effort to address the complexities of NP drug development. …”
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A Review of the Digital Twin Technology in the AEC-FM Industry by Haidar Hosamo Hosamo, Aksa Imran, Juan Cardenas-Cartagena, Paul Ragnar Svennevig, Kjeld Svidt, Henrik Kofoed Nielsen

“…The findings show that information standardization is the first major hurdle that must be overcome before the actual use of Digital Twin can be realized in the AEC-FM industry. …”
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Sacred Bonds or Sinful Ties? Interreligious Marriage in Islamic Law by Rafli Zidan Eka Ramadhan, Rohadhatul Aisy, Shofriya Qonitatin Abidah, Fateema Muslihatun Najihah, Bagus Hendradi Kusuma

“…Additionally, interfaith couples often encounter significant legal and social hurdles, including issues related to inheritance, child custody, and religious conversion. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…However, challenges related to data privacy, algorithm transparency, and clinical integration must be addressed. Overcoming these hurdles will likely make AI a central component of future cancer immunotherapy, offering more personalized and effective treatments.…”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…In this study, we aimed to investigate the role of EPN3 in modulating EGFR function, its effects on NSCLC progression, and its potential involvement in tyrosine kinase inhibitor (TKI) resistance, which remains a significant hurdle in NSCLC treatment. Results Our findings revealed that the expression of EPN3 is significantly up-regulated in NSCLC patients. …”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…However, widespread implementation faces several challenges: (1) characterizing dynamic molecular changes across multiple biological scales; (2) developing computational methods to integrate data into DTs; (3) prioritizing disease mechanisms and therapeutic targets; (4) creating interoperable DT systems that can learn from each other; (5) designing user-friendly interfaces for patients and clinicians; (6) scaling DT technology globally for equitable healthcare access; (7) addressing ethical, regulatory, and financial considerations. Overcoming these hurdles could pave the way for more predictive, preventive, and personalized medicine, potentially transforming healthcare delivery and improving patient outcomes.…”
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