Minimizing Adverse Environmental Impact: How Murky the Waters by Reed W. Super, David K. Gordon

“…However, in an attempt to avoid compliance costs, industry has seized on the statutory phrase “adverse environmental impact” to propose significant procedural and substantive hurdles and layers of uncertainty in the permitting of cooling-water intakes under the Clean Water Act. …”
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Do We Need CO2 Shadow Prices on Public Expenditures? by Andreas Löschel, David Schulze

“…The expected effect is limited by the low price range, the short planning horizon and the current limited application to federal expenditures. Potential hurdles include the legal complexity and the effort required to avoid double burdens should the scope of shadow pricing be extended to state and municipal levels. …”
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Modeling Hospitalization Decision and Utilization for the Elderly in China by Xin Xu, Dongxiao Chu

“…One aim of this study was to use zero-inflated and hurdle models to better solve the problem of excess zeros. …”
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Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes by Shuang Gao, Yuanyuan Zhang, Kaini Liang, Ran Bi, Yanan Du

“…Moreover, we highlight the importance of understanding the pharmacokinetics (PK) of transplanted cells and discuss the hurdles in MSC-based T2DM therapy toward future clinical applications.…”
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Surgical modalities in the treatment of vitiligo by R. Vignesh Narayan, Vishal Thakur

“…While medical therapies can halt disease progression, achieving repigmentation, especially in challenging areas, remains a hurdle. Surgical interventions, including therapeutic wounding, camouflage techniques, excision, and grafting methods, offer viable solutions. …”
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Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm by Jitendra Parmar, Tapan Patel, Sandip Shah, Jay Kothari, Sameer Dani, Sagar Vyas

“…Herein, we present the first case report of bilateral renal artery dissection in a 41-year-old male patient who recently recovered from COVID-19 and was managed successfully in stages after many medical hurdles.…”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Industry efforts focus on developing devices or solutions for vascular aging assessment and treatment strategies, yet face hurdles in large-scale adoption and reimbursement. …”
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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses by Alice Njolke Mafe, Great Iruoghene Edo, Osamah S. Majeed, Tayser Sumer Gaaz, Patrick Othuke Akpoghelie, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Joseph Oghenewogaga Owheruo, Rapheal Ajiri Opiti, Yasal Garba, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…By examining the connections between probiotics, gut microbiota, and outcomes such as digestive health, immune function, and metabolic well-being, this review identifies conditions where probiotics show potential benefits. It also addresses hurdles, including variability in strain effectiveness and dosage, and outlines future research areas, particularly personalized probiotic approaches. …”
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Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…Despite significant progress, challenges such as translational hurdles, cost barriers, and long-term efficacy require further investigation. …”
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GENDER EQUALITY AND ECONOMIC DEVELOPMENT IN NIGERIA: THE ROLE OF CIVIL SOCIETY by KAZEEM ADEREMI ASIYANBI, AHMED YUSUF BABATUNDE, ADENIYI MICHAEL ADEWUSI

“…It examines the techniques used by CSOs, assesses their impact on policy reforms and public attitudes, and analyzes the hurdles to accomplishing their goals. This study emphasized the literature rather than the major concerned respondents that have been the focus of previous researchers.  …”
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Sustainable 3D printing of bone scaffolds using animal biowaste feedstocks by A. Dukle, M. Ravi Sankar

“…The study also addresses the challenges and future perspectives of biowaste-derived feedstocks for bone tissue engineering, including regulatory hurdles, biocompatibility, and scalability.…”
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Maize Market Chain Analysis and the Determinants of Market Participation in the Gamo and Gofa Zones of Southern Ethiopia by Duge Galtsa, Kassa Tarekegn, Kusse Kamaylo, Endrias Oyka

“…The data were analyzed by using descriptive statistics, marketing margins, and the double hurdle model. The survey results revealed that approximately 35.88% of the maize from the total maize produced by the sampled farmers was marketed in the study area. …”
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Forced to Reimagine: Reflections on the Experience of Leicester Vaughan College Community Benefit Society by Miriam Gill, Lucy Faire

“…As we searched (and continue to search) for a ‘happy ending’ with LVC, the multiple hurdles experienced exemplify the difficulties of trying to create a space for a new paradigm within hostile, shifting structures shaped by neoliberal regulatory and economic imperatives. …”
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ETHNIC POLITICS AND SUSTAINABLE DEMOCRACY IN NIGERIA by UKWU FELIX EMEKA

“…The research contends that the endemic nature of ethnic politics presents significant hurdles to democracy's survival in Nigeria. The findings reveal various symptoms and ramifications of ethnic politics that hinder the consolidation of democracy, including heightened calls for self-determination, escalating insecurity, and stalled development. …”
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Immediate shock and residual stress: Unmasking the dual dynamics of covid-19 on the mental health of health professionals in China by Suyi Duan

“…It has posed extraordinary hurdles for Chinese health workers, affecting their mental health with respect to situations in the present as well as the future. …”
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Usage of Probabilistic and General Regression Neural Network for Early Detection and Prevention of Oral Cancer by Neha Sharma, Hari Om

“…It is critical to ascertain the diagnosis in order to initiate most advantageous treatment of the suspicious lesions. The main hurdle in appropriate treatment and control of oral cancer is identification and risk assessment of early disease in the community in a cost-effective fashion. …”
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QeMFi: A Multifidelity Dataset of Quantum Chemical Properties of Diverse Molecules by Vivin Vinod, Peter Zaspel

“…Much research is progressing in this direction for diverse applications ranging from energy band gaps to excitation energies. One hurdle for effective research here is the lack of a diverse multifidelity dataset for benchmarking. …”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…In this paper, we review up-to-date clinical trials of GBM treatments in order to overcome these 4 hurdles and to aim at more therapeutical effect than conventional therapies that are ongoing or are about to launch in clinical settings and discuss future perspectives.…”
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Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…However, the delivery of nucleic acids to the central nervous system (CNS) by the systemic route, remains a major hurdle. To overcome this pitfall, this review focuses on oligonucleotide-based novel strategies including liposomes, carbon nanotubes, quantum dots, solid lipid nanoparticles, nano lipid carriers, polymeric nanoparticles, mesoporous silica, dendrimers, aptamers, nanobodies etc. …”
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Comparison of Flow Solutions for Naturally Fractured Reservoirs Using Complex Analysis Methods (CAM) and Embedded Discrete Fracture Models (EDFM): Fundamental Design Differences an... by Aaditya Khanal, Ruud Weijermars

“…One aim is to define scaling rules for the strength (flux) of the discrete natural fractures used in CAM models, which was previously theoretically defined based on the expected flow distortion. A major hurdle for quantitative benchmarks of CAM with EDFM results is that each of the two methods accounts for natural fractures with different assumptions and input parameters. …”
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