Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Issues such as standardization, regulatory approval, and supply sustainability remain significant hurdles. Overcoming these limitations requires a concerted effort to address the complexities of NP drug development. …”
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A Review of the Digital Twin Technology in the AEC-FM Industry by Haidar Hosamo Hosamo, Aksa Imran, Juan Cardenas-Cartagena, Paul Ragnar Svennevig, Kjeld Svidt, Henrik Kofoed Nielsen

“…The findings show that information standardization is the first major hurdle that must be overcome before the actual use of Digital Twin can be realized in the AEC-FM industry. …”
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Sacred Bonds or Sinful Ties? Interreligious Marriage in Islamic Law by Rafli Zidan Eka Ramadhan, Rohadhatul Aisy, Shofriya Qonitatin Abidah, Fateema Muslihatun Najihah, Bagus Hendradi Kusuma

“…Additionally, interfaith couples often encounter significant legal and social hurdles, including issues related to inheritance, child custody, and religious conversion. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…However, challenges related to data privacy, algorithm transparency, and clinical integration must be addressed. Overcoming these hurdles will likely make AI a central component of future cancer immunotherapy, offering more personalized and effective treatments.…”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…In this study, we aimed to investigate the role of EPN3 in modulating EGFR function, its effects on NSCLC progression, and its potential involvement in tyrosine kinase inhibitor (TKI) resistance, which remains a significant hurdle in NSCLC treatment. Results Our findings revealed that the expression of EPN3 is significantly up-regulated in NSCLC patients. …”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…However, widespread implementation faces several challenges: (1) characterizing dynamic molecular changes across multiple biological scales; (2) developing computational methods to integrate data into DTs; (3) prioritizing disease mechanisms and therapeutic targets; (4) creating interoperable DT systems that can learn from each other; (5) designing user-friendly interfaces for patients and clinicians; (6) scaling DT technology globally for equitable healthcare access; (7) addressing ethical, regulatory, and financial considerations. Overcoming these hurdles could pave the way for more predictive, preventive, and personalized medicine, potentially transforming healthcare delivery and improving patient outcomes.…”
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Implementing an intrahospital transport preparation (IHT) and management project for critically ill patients: identification of barriers and facilitators using consolidated framewo... by Jing Wang, Li Ma, Ying Lu, Baohua Li, Xiaotian Zhang, Rui Xie, Guifen Li, Man Cui, Lanfang Du

“…Facilitators were identified in four primary domains: ease of implementation, scientific and project completion, patient advantages and enhanced capacity for safe and professional transfer. Additionally, hurdles were identified in the CFIR domains of intervention characteristics, outer settings and inner settings. …”
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The Wilson's disease - etiology, symptoms in various organs, diagnosis, treatment, prognosis by Patryk Graczyk, Paulina Klaudia Kwaśniewska, Anna Wilewska, Kinga Borowiec, Agnieszka Borowiec, Julia Biernikiewicz, Konstanty Alabrudziński, Milena Biernikiewicz, Bartosz Pomirski, Agata Pomirska

“…However, nonadherence to lifelong therapy remains a major hurdle, emphasizing the need for ongoing patient education. …”
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Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells by Markus Bergqvist, Kyong-Su Park, Nasibeh Karimi, Lijuan Yu, Cecilia Lässer, Jan Lötvall

“…Abstract Extracellular vesicles (EVs) are taken up by most cells, however specific or preferential cell targeting remains a hurdle. This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercellular adhesion molecule-1 (ICAM-1). …”
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Six-Phase Fully Coreless Axial-Flux Permanent-Magnet Generator: Design, Fabrication, and Performance Analysis by Turki M. Alsuwian, Asiful Habib, Muhammad Ammirrul Atiqi Mohd Zainuri, Ahmad Asrul Ibrahim, Nasrudin Abd Rahim, Adam R. H. Alhawari, Abdulkarem H. M. Almawgani, Saleh Almasabi, A. T. Hindi, Mohamed Fauzi Packeer Mohamed

“…Nevertheless, the proliferation of coreless AFPM machines faces hurdles as to high leakage flux and weaker structural integrity. …”
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Optical Imaging Biomarkers of Drug-Induced Vascular Injury by Shu-An Lin MS, Donna L. Suresch, Brett Connolly, Gebre Mesfin, Raymond J. Gonzalez, Manishkumar R. Patel, Diane Shevell, Timothy Johnson, Bohumil Bednar

“…Drug-induced vascular injury (DIVI), defined as arterial medial degeneration/necrosis usually associated with perivascular inflammation, is frequently observed in the mesenteric arteries of rats but the relevance to humans remains a hurdle for drug development. Here, we describe the evaluation of commercially available optical imaging biomarkers using a rat DIVI model. …”
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D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer by Takashi Harino, Koji Tanaka, Daisuke Motooka, Yasunori Masuike, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…Abstract Esophageal cancer is a highly aggressive disease, and acquired resistance to chemotherapy remains a significant hurdle in its treatment. mtDNA, crucial for cellular energy production, is prone to mutations at a higher rate than nuclear DNA. …”
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Factors influencing livestock ownership and herd intensity among smallholder farmers in the Eastern Cape, South Africa by Jabulile Z. Manyike, Amon Taruvinga, Leocadia Zhou

“…Data were collected through a semi-structured questionnaire and analysed using a double hurdle model. The findings reveal that the decision to own livestock is positively influenced by adherence to African traditional religion, access to climate information, membership in farming organizations, income diversification, possession of formal housing, exposure to high average temperatures, and the likelihood of being in female-headed households. …”
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Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Notably, neuroscience drug development encounters distinct challenges, including the complex nature of diseases, limitations imposed by the blood–brain barrier, the absence of reliable predictive preclinical models, and regulatory hurdles. Ethical and safety considerations are pivotal due to the potential cognitive and motor effects of CNS-active drugs. …”
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Design and implementation of an asynchronous online course-based undergraduate research experience (CURE) in computational genomics. by Seema B Plaisier, Danielle O Alarid, Joelle A Denning, Sara E Brownell, Kenneth H Buetow, Katelyn M Cooper, Melissa A Wilson

“…As genomics technologies advance, there is a growing demand for computational biologists trained for genomics analysis but instructors face significant hurdles in providing formal training in computer programming, statistics, and genomics to biology students. …”
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Reliability and Differences Between Sexes in Landing Mechanics when Performing the Lateral Bound Test by Andy Waldhelm, Sydney Allen, Lacy Grand, Carolyn Bopp, Kristian Foster, Ginger Muckridge, Neil Schwarz

“… # Materials/Methods Each subject performed three trials of a LBT which included jumping laterally from one leg over a hurdle and landing on the opposite leg. Two cameras were placed six feet from the landing marker. …”
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Repeatability and High-Speed Validation of Supplemental Lead-Extrusion Energy Dissipation Devices by Geoffrey W. Rodgers, J. Geoffrey Chase, John B. Mander

“…However, despite several research study tests and a limited range of velocity testing, they have never been tested across a realistic velocity range or for robustness to manufacture and design across several devices. These issues are hurdles that limit professional design uptake and add uncertainty and risk to their use in design. …”
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Challenges of Blockchain Implementation in Construction by Ahsan Waqar, Lubna A. Alharbi, Faiz Abdullah Alotaibi, Khaled A. Alrasheed, Abdul Mateen Khan, Hamad Almujibah

“…Furthermore, this research study has revealed that the primary, social, and economic hurdles for implementation of blockchain technology in extensive building projects are stakeholders’ reluctance to change, disputes over ownership, and the challenge of demonstrating a definitive return on investment. …”
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Genetic diversity and differentiation of cultured Nile tilapia populations from Ethiopia revealed by ddRAD-seq: implications for better hatchery management by Geletu Temesgen Tola, Tang Shoujie, Zhao Jinliang

“…Hence, the development of aquaculture in Ethiopia faces a major hurdle owing to the absence of good-quality seeds, largely because of the lack of genetic management practices within hatchery centers. …”
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The small modular molten salt reactor potential and opportunity in Saudi Arabia by Dana Hejazi, Anas M. Alwafi, Salman M. Alzahrani, Meshari M. Alqahtani, Salman M. Alshehri

“…While implementing MSRs requires overcoming technical hurdles, mainly related to structural materials withstanding extreme conditions, Saudi Arabia’s thriving research ecosystem is well-suited for overcoming such challenges. …”
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