From Bench to Brain: A Metadata-driven Approach to Research Data Management in a Collaborative Neuroscientific Research Center by Marlene Pacharra, Tobias Otto, Nina Olivia Caroline Winter

“…Using this metadata schema, neuroscientific data from more than 3,200 human subjects and lab animals are currently shared within the CRC. …”
Get full text

Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease by Neng-jun Lou, Yi-hong Ni, Hong-ying Jia, Jing-ti Deng, Lu Jiang, Feng-jie Zheng, Ai-li Sun

“…This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD). 31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study. …”
Get full text

Point of Care Perioperative Coagulation Management in Liver Transplantation and Complete Portal Vein Thrombosis by Cristiano Piangatelli, Lucia Faloia, Claudia Cristiani, Ilaria Valentini, Marco Vivarelli

“…Based on ROTEM findings, the patient received 16 g of human fibrinogen concentrate, half preoperatively (with prothrombin complex concentrate 2000 IU, tranexamic acid 1 g, and platelets 2 IU), and two doses of 4 g before and after graft reperfusion; we achieved normalization of all monitored parameters. …”
Get full text

Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin by Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin

“…The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested. …”
Get full text

The Effect of Organizational Intelligence on Improving the Performance of Bushehr Public Library Staff by Abbas Doulani, mahnaz saadat, Roya Baradar

“…Identifying and strengthening the various components of organizational intelligence can enhance library staff performance.Value: This research emphasizes the importance of human resources and highlights the role of organizational intelligence in improving performance, which is particularly relevant in the context of public libraries.…”
Get full text

Preliminary Evaluation of a Nuclear Scenario Involving Innovative Gas Cooled Reactors by Barbara Vezzoni, Nicola Cerullo, Giuseppe Forasassi, Emil Fridman, Guglielmo Lomonaco, Vincenzo Romanello, Eugene Shwageraus

“…., EPR-SNF directly disposed) shows a reduction of the time needed to reach a fixed reference level from ∼170000 years to ∼1550 years (comparable with typical human times and for this reason more acceptable by the public opinion). …”
Get full text

Adaptive Recognition of Motion Posture in Sports Video Based on Evolution Equation by Rui Yuan, Zhendong Zhang, Yanyan Le, Enqing Chen

“…The application of artificial intelligence technology to the training of athletes to recognize athletes’ posture can help coaches assist in decision-making and greatly enhance athletes’ competitive ability. The human body movements embodied in sports are more complicated, and the accurate recognition of sports postures plays an active and important role in sports competitions and training. …”
Get full text

MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production by Xinrui Yang, Jing Liu, Yaru Yin, Luxun Yang, Mingquan Gao, Zifei Wu, Binghui Lu, Shenglin Luo, Weidong Wang, Rong Li

“…In this study, we investigate the therapeutic potential of human umbilical cord-derived mesenchymal stem cell exosomes (MSC-EXs) in mice exposed to DU. …”
Get full text

Dose and strain dependent lethality of Usutu virus in an Ifnar−/− mouse model by Johanna M. Duyvestyn, Eleanor M. Marshall, Peter J. Bredenbeek, Barry Rockx, Martijn J. van Hemert, Marjolein Kikkert

“…While usually mild or asymptomatic in humans, neurological disorders are increasingly observed, which has boosted interest and the need for better understanding of the pathogenesis of various USUV lineages. …”
Get full text

Motivations of Retailers Accepting Cryptocurrency Payments and Their Implications on Retail Customer Experience by Muhammed Ali Yetgin, Kasım Yılmaz, Volkan Temizkan

“…The level of technology use of humanity has increased, while the interest in digital assets has increased with the effect of the pandemic period. …”
Get full text

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…The copy number and scRT profiles obtained by analysing >119,000 high-quality human single cells from different cell lines, patient tumours and patient-derived xenograft samples leads to a multi-sample heterogeneity-resolved scRT atlas. …”
Get full text

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. …”
Get full text

Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor by Bilasini Devi Naorem, Jatinder Pal Singh, Babita Sharma, Satyam Garg, Athira C, Hashima Sherin, Mahima Momaliya, Muskan, Shubhi Sahu, Arijit Chowdhuri, Mallika Verma, Monika Tomar, Neha Batra

“…The fabricated biosensor exhibits excellent performance in terms of sensitivity (40 µAmM-1cm-2), selectivity with <5 % deviation found in presence of other known markers present in human sera, and shelf life >12 weeks, enabling precise and sensitive uric acid detection. …”
Get full text

Elevated Blood Ammonia Level Is a Potential Biological Risk Factor of Behavioral Disorders in Prisoners by Yunfeng Duan, Xiaoli Wu, Shan Liang, Feng Jin

“…Hydrothion (H2S) and ammonia (NH3) can be toxic for the human central nervous system and cause psychological disturbances and behavioral disorders. …”
Get full text

Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging by Iorhen Ephraim Akase, Bolanle O. P. Musa, Reginald Onyedumarakwe Obiako, Abdurrahman Ahmad Elfulatiy, Abdullahi Asara Mohammed

“…The serum concentrations of cytokines IL-6 and IL-10 were carried out using R&D human Quantikine ELISA kits, while patients’ CD4+ T cell counts were evaluated using the Partec easy count kit. …”
Get full text

High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma by Wei Sun, Qi Su, Xiankui Cao, Bin Shang, Aishan Chen, Hongzhuan Yin, Baolin Liu

“…Thus, we presume that the status of PLK1 expression might be an independent prognostic factor for HCC and targeting PLK1 might be a useful strategy for diagnosis and treatment of human HCC.…”
Get full text

Monitoring of ant species surrounding the ports of South Korea by Dayeong Kim, Heejo Lee, Nanghee Kim, Beom-jun Jang, Dong Eon Kim

“…The introduction and spread of invasive insects is accelerating worldwide owing to human activities, such as trade and transportation development; in particular, ports are hubs and routes for invasive insects, including ants. …”
Get full text

NIR‐II emissive biohybrid nanovesicles as mild‐temperature photothermal antibiofilm agents against acute bacterial skin and skin‐structure infections by Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao

“…Bacterial biofilms are naturally resistant to antibiotics and the human immune system, making biofilm‐based infections extremely difficult to treat. …”
Get full text

Helicobacter pylori Infection, Chronic Inflammation, and Genomic Transformations in Gastric MALT Lymphoma by Magdalena Witkowska, Piotr Smolewski

“…Occasionally, it can be found in salivary and thyroid gland, lung, breast, bladder, skin, or any other place in the human body. This paper is a review of the current knowledge on etiology, pathogenesis, treatment, and follow-up of gastric MALT lymphoma.…”
Get full text

IL-1 and its role in rat carrageenan pleurisy by R. Goodman, L. R. Mantegna, C. L. McAIlister, E. Bruin, R. L. Dowling, H. George, W. Feeser, B. Freimark, M. Lischwe, S. Pick, R. R. Harris, J. S. Kerr

“…None of the drugs tested, including the IL-1 receptor antagonist, maintained pleural cell influx and IL-1β levels at control levels. When human IL-1α or β or rat IL-1β were injected individually into the pleural cavity, none of these cytokines were pro-inflammatory, as measured by increased cell influx and fluid extravasation. …”
Get full text