Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications by Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang

“…Therefore, restoring the balance in autoimmune regulation is essential because proatherogenic and antiatherogenic immunomodulatory effects are equally important in the complex human immune network. In this review, we summarized the recent evidence of the roles of proatherogenic and antiatherogenic immune networks in the pathogenesis of ACS and discussed how immune and inflammation contribute to atherosclerosis progression, plaque instability, and adverse cardiovascular events. …”
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Chronic nitrogen legacy in the aquifers of China by Xin Liu, Fu-Jun Yue, Li Li, Feng Zhou, Hang Wen, Zhifeng Yan, Lichun Wang, Wei Wen Wong, Cong-Qiang Liu, Si-Liang Li

“…Here we used machine learning and decision tree-heatmap analysis by compiling nitrate concentrations and isotope data from 4047 groundwater sites across China to understand their dynamics and drivers across gradients of geographical, climate, and human factors. Results show that nitrate concentrations vary substantially over depth and are generally lower in deeper groundwater, indicating potentially higher nitrate removal rates according to nitrate isotopic pattern such as denitrification at depth. …”
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Effect of Hepatitis E Virus on the Male Reproductive System: A Review of Current Evidence by Ahmed A. Kotb, Mohamed A. El-Mokhtar, Ibrahim M. Sayed

“…However, the effect of HEV infection on male infertility is not confirmed. One study including human samples showed male infertility associated with HEV genotype 4 infection. …”
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An Incremental Self-Adaptive Wood Species Classification Prototype System by Peng Zhao, Zhen-Yu Li, Yue Li

“…Last, if one cluster of one unknown species has an adequate amount of wood samples, these wood samples are removed and identified by human experts or other schemes to ensure to get the correct wood species name. …”
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Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target by Mingxia Wang, Shangling Zhu, Weixiang Peng, Qiuxia Li, Zhaoxia Li, Minqi Luo, Xiaoxue Feng, Zhuofeng Lin, Jianlin Huang

“…Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, and is activated in a number of malignancies. …”
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Evaluation of hesperidin as a potential larvicide against Culex pipiens with computational prediction of its mode of action via molecular docking by Abdullah Haikal, Mahmoud Kamal, Eslam M. Hosni, Yhiya Amen

“…Culex pipiens, commonly known as the northern house mosquito, is a major vector of several human pathogens, such as the West Nile virus and filariasis, making it a key target in the fight against vector-borne diseases. …”
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Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma by Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng

“…Furthermore, the CAR-NK-92 cells show synergistic therapeutic efficacy with cabozantinib against human RCC xenograft models. Our results provided the basis for combination with chemotherapy as a novel strategy for enhancing the therapeutic efficacy of CAR-modified immune effector cells for solid tumors.…”
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Inhibition of mutagenic activation of orthoaminoazotoluene increases its carcinogenicity for mouse liver by V. I. Kaledin, L. P. Ovchinnikova, S. I. Ilnitskaya, T. S. Morozkova, N. A. Popova

“…Various mutationally impaired genes are often found in malignant tumors of animals and humans. At the same time, a large number of carcinogens demonstrate positive activity in different in vitro tests for mutagenicity. …”
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ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure by Qing Liu, Dan Liu, Yuejiao Wang, Xiaowei Wei, Wei Ma, Hui Gu, Shanshan Jia, Yiwen He, Wenting Luo, Songying Cao, Zhonghua Yang, Anhua Wu, Zhengwei Yuan

“…We demonstrated that ApoM expression was reduced in the spinal cord samples of rat models and human fetuses with NTDs respectively. Specifically, lack of ApoM resulted in reduced cytosolic localization of Elavl2 and caused Nnt mRNA degradation, which further led to impaired cell homeostasis by suppressing PINK1-PRKN-mediated mitophagy and promoting apoptosis and subsequent NTDs formation. …”
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Breaking the Frame: Arabesque and Metric Complexity in the Sunrise Scene from Ravel’s Daphnis et Chloé (1912) by Gurminder Kaur Bhogal

“…At this moment, the motif bursts into the foreground to suggest the symbolic fusion of nature, divinity, and human emotion. The structural role of the arabesque figure on metric and narrative levels unsettles prevailing viewpoints of ornament as meaningless and non-essential. …”
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ExAIRFC-GSDC: An Advanced Machine Learning-Based Interpretable Framework for Accurate Gas Leakage Detection and Classification by B. Lalithadevi, S. Krishnaveni

“…This research focuses on developing advanced systems that promptly identify gas types to prevent harm to human lives and the environment. This paper addresses the challenges of gas leakage detection and classification in diverse environments, such as industrial, residential, and mining scenarios. …”
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Fat from Tenebrionidae Bugs - Sterols Content, Fatty Acid Profiles, and Cardiovascular Risk Indexes by Jiri Mlcek, Anna Adamkova, Martin Adamek, Marie Borkovcova, Martina Bednarova, Ivana Knizkova

“…This work focused on analysing the content of selected sterols and profile of fatty acids of edible insect species – mealworm ( Tenebrio molitor ) and superworm ( Zophobas morio ), which are expected to increase their usability in human nutrition. Sterols content was determined using capillary gas chromatography method. …”
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Recalculating: The atlas of pragmatic parameters of developmental disorders by Anita Viszket, Alexandra Hoss, Eszter Kárpáti, Gábor Alberti

“…The model is built upon the idea that the worldlets are organized in a system of multi-level tree-structures and are easily processable and accessible in communication for the intact human mind. In this formally defined system, the intensity of the different BDIs (e.g. strong/weak belief) belonging to the worldlets must be signaled by the interlocutors, using pragmatic tools. …”
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Migratory Dates, Breeding Phenology, and Reproductive Success of European Turtle Doves between Lowlands and Highest Breeding Habitats in North Africa by Ismail Mansouri, Mohamed Mounir, Wafae Squalli, Laila Elhanafi, Mohamed Dakki, Lahsen El Ghadraoui

“…Moreover, at Midelt, 18.89% of eggs and 10.54% of chicks were predated, while at Beni Mellal 21.80% of eggs and 4.65% of chicks were deserted due to human disturbance. As a response, at Midelt breeding period was shorter and shifted to hot periods to ensure better reproductive success. …”
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Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence by Sashini D. Perera, Uthpala A. Jayawardena, Chanika D. Jayasinghe

“…Eight full papers were entitled to the review; out of those, two studies focused on ethnobotanical surveys, three on animal experiments, one on human trial, and two on in vitro antiviral activities, and one was computational study. …”
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Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis by Svetla Nikolova, Milka Dikova, Dobrin Dikov, Assen Djerov, Gyulnas Dzhebir, Ventseslav Atanasov, Alexey Savov, Ivo Kremensky

“…Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). …”
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Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells by Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke

“…Of these special cell-cell junctions containing desmosomal glycoproteins or proteins we review the composite junctions (areae compositae) connecting the cardiomyocytes of mature mammalian hearts and their importance in relation to human arrhythmogenic cardiomyopathies. We also emphasize the various plakophilin-2-positive plaques in AJs (coniunctiones adhaerentes) connecting proliferatively active mesenchymally-derived cells, including interstitial cells of the heart and several soft tissue tumor cell types. …”
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Research progress in integrated groundwater-surface water models by Shuyan PENG, Zheng LU, Tingting WU, Xiaofan YANG

“…The integrated models are widely used to study the changes in groundwater-surface water patterns under the influences of climate change and human activities, and to research water resources management and optimization. …”
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Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens by Ikbel Naouar, Thouraya Boussoffara, Melika Ben Ahmed, Nabil Belhaj Hmida, Adel Gharbi, Sami Gritli, Afif Ben Salah, Hechmi Louzir

“…Collectively, our data indicate that LmES are immunogenic in humans and emphasize the involvement of CD4+ T cells including activated and regulatory T cells in the immune response against parasite antigens.…”
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Occurrence and Removal Characteristics of Phthalate Esters from Typical Water Sources in Northeast China by Yu Liu, Zhonglin Chen, Jimin Shen

“…As drinking water is a major source for human exposure to PAEs, the fate of target PAEs in the two waterworks (Mopanshan Waterworks and Seven Waterworks) was also analyzed. …”
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