Role of Cathepsin S in Periodontal Inflammation and Infection by S. Memmert, A. Damanaki, A. V. B. Nogueira, S. Eick, M. Nokhbehsaim, A. K. Papadopoulou, A. Till, B. Rath, S. Jepsen, W. Götz, C. Piperi, E. K. Basdra, J. A. Cirelli, A. Jäger, J. Deschner

“…The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions elicited by interleukin-1β and Fusobacterium nucleatum, respectively. …”
Get full text

Sensory Deprivation during Early Postnatal Period Alters the Density of Interneurons in the Mouse Prefrontal Cortex by Hiroshi Ueno, Shunsuke Suemitsu, Yosuke Matsumoto, Motoi Okamoto

“…Recent study using functional MRI in humans suggests a role of the prefrontal cortex (PFC) in cross-modal plasticity. …”
Get full text

Quantifying glucose uptake at the single cell level with confocal microscopy reveals significant variability within and across individuals by Joel D. Paprocki, Patrick J. Macdonald, Yongjin Xu, Alan Cheng, Timothy C. Dunn, Sergey Y. Tetin

“…Abstract Measurement of glycated hemoglobin (HbA1c) in human red blood cells plays a critical role in the diagnosis and treatment of diabetes mellitus. …”
Get full text

Optimal Control Problem of Treatment for Obesity in a Closed Population by D. Aldila, N. Rarasati, N. Nuraini, E. Soewono

“…This is due to the difficulty in parameterizing the human interaction and transition process of obesity. …”
Get full text

Whole Exome Sequencing Uncovers Germline Variants of Cancer-Related Genes in Sporadic Pheochromocytoma by Milena Urbini, Margherita Nannini, Annalisa Astolfi, Valentina Indio, Valentina Vicennati, Matilde De Luca, Giuseppe Tarantino, Federica Corso, Maristella Saponara, Lidia Gatto, Donatella Santini, Guido Di Dalmazi, Uberto Pagotto, Renato Pasquali, Andrea Pession, Guido Biasco, Maria A. Pantaleo

“…Pheochromocytomas (PCCs) show the highest degree of heritability in human neoplasms. However, despite the wide number of alterations until now reported in PCCs, it is likely that other susceptibility genes remain still unknown, especially for those PCCs not clearly syndromic. …”
Get full text

Advanced decision analytics with fuzzy logic integrating AI and computational thinking for personnel selection by Mudiarasan Kuppusamy, Jugindar Singh, Priya Raman, Neda Abdolrahimi

“…However, numerous companies have Human Resources (HR) teams that deal with this issue. …”
Get full text

HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY... by Salvatore Siena, Kanwal Raghav, Toshiki Masuishi, Kensei Yamaguchi, Tomohiro Nishina, Elena Elez, Javier Rodriguez, Ian Chau, Maria Di Bartolomeo, Hisato Kawakami, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Issey Takehara, Daniel Barrios, Kojiro Kobayashi, Axel Grothey, Takayuki Yoshino

“…Abstract DESTINY-CRC01 (NCT03384940) was a multicentre, open-label, phase 2 study that investigated the safety and efficacy of trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2 (HER2)-expressing metastatic colorectal cancer (CRC). …”
Get full text

Molecular Characterization and Risk Factors of Giardia duodenalis among School Children from La Habana, Cuba by Luis Enrique Jerez Puebla, Fidel A. Núñez, Isabel Martínez Silva, Lázara Rojas Rivero, Marta Martínez González, Yuliet Méndez Sutil, Lucía Ayllón Valdés, Iraís Atencio Millán, Norbert Müller

“…Giardia duodenalis is considered the most common protozoan infecting humans worldwide. Molecular characterization of G. duodenalis isolates has revealed the existence of eight groups (assemblages A to H) which differ in their host distribution. …”
Get full text

Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis by David J. Gifondorwa, Ramon Jimenz-Moreno, Crystal D. Hayes, Hesam Rouhani, Mac B. Robinson, Jane L. Strupe, James Caress, Carol Milligan

“…We previously reported that recombinant human hsp70 (rhHsp70) injections delayed symptom onset and increased lifespan in SOD1G93A mice. …”
Get full text

CAREER ADMINISTRATION AS A DETERMINANT OF PROACTIVE BEHAVIOR by Azman Ismail, Wan Aishah Wan Mohd Nowalid, Azmawaty Mohamad Nor

“…By addressing the duo problem of organizational development and the human aspect of organization, career administration considers as expedient, having proactive individuals who assist in moving the organization forward. …”
Get full text

The Role of PPARs in Placental Immunology: A Systematic Review of the Literature by Stefan Hutter, Julia Knabl, Ulrich Andergassen, Udo Jeschke

“…They are expressed in most human organs and their function extends from regulating metabolism, homeostasis, and carcinogenesis to immune response. …”
Get full text

Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma by Mei Liu, Su-jun Zheng, Yu Chen, Ning Li, Peng-fei Ren, Li-ping Dai, Zhong-ping Duan, Jian-Ying Zhang

“…The prevalence of autoantibodies against MDM2 was significantly higher than that in liver cirrhosis (LC), chronic hepatitis (CH), and normal human sera (NHS). The average titer of autoantibodies against MDM2 in HCC serum was higher compared to that in LC, CH, and NHS. …”
Get full text

Integrating Satellite Data and In-situ Observations for Trophic State Assessment of Renuka Lake, Himachal Pradesh, India by Sujit Kumar Jally, Rakesh Kumar and Sibabrata Das

“…The sustained eutrophic condition is attributed to escalating human-induced activities surrounding the lake, particularly in the western region.…”
Get full text

Project-based learning through augmented reality-assisted math trails at Blenduk Church to promote mathematical literacy by Muhammad Andi Nugroho, Indriana Yulandari, Adi Nur Cahyono

“…In the field of education, the era of society 5.0 has a great impact, so education must be able to produce human resources who have good mathematical literacy and are able to apply technology well with their literacy abilities. …”
Get full text

Zoning the villages at flood risk in the Varkesh-Chai drainage basin by GIS and HEC - RAS software and HEC- GEO - RAS extension by Asdollah hejazi, fatemeh khodaie geshlag, leila khodaie geshlag

“…Lack of knowledge and attention to the above-mentioned cases and river bed manipulation has increased the vulnerability of villages, agricultural land or other human facilities of the flood risk in the catchment area. …”
Get full text

GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 by Yu You, Konglin Huo, Liang He, Tongyue Wang, Lei Zhao, Rong Li, Xiaoqing Cheng, Xuebin Ma, Zhiying Yue, Stefan Siwko, Ning Wang, Lujian Liao, Mingyao Liu, Jian Luo

“…Moreover, the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss. In humans, serum GnIH increases and bone resorption markers decrease after green light exposure. …”
Get full text

A Comparison of Cholesterol Uptake and Storage in Inflammatory and Noninflammatory Breast Cancer Cells by Breonna J. Martin, Kenneth L. van Golen

“…Our results demonstrate that compared with human mammary epithelial cells (HMECs), both IBC and non-IBC cells have increased cholesterol content. …”
Get full text

Synthesis of Anti-Inflammatory Drugs’ Chalcone Derivatives and a Study of Their Conformational Properties Through a Combination of Nuclear Magnetic Resonance Spectroscopy and Molec... by Nikitas Georgiou, Andromachi Tzani, Kyriaki Vavougyiou, Christos Papadopoulos, Nikolaos Eleftheriadis, Primož Šket, Demeter Tzeli, Tuomas Niemi-Aro, Anastasia Detsi, Thomas Mavromoustakos

“…Finally, their selectivity profile was investigated against human 15-LOX-1 and general Lipoxidase activity. Conclusions: The in silico methods suggest that chalcones could be promising lead compounds for drug designs targeting the LOX enzyme.…”
Get full text

A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters by Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa

“…Treatment of human immunodeficiency virus type 1 (HIV-1) infection during the symptomatic phase has significantly improved patient survival. …”
Get full text

Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells by Shanti Klingspor, Angelika Bondzio, Holger Martens, Jörg R. Aschenbach, Katharina Bratz, Karsten Tedin, Ralf Einspanier, Ulrike Lodemann

“…Porcine (IPEC-J2) and human (Caco-2) intestinal cells were incubated without bacteria (control), with E. faecium, with enteropathogenic (EPEC) or enterotoxigenic E. coli (ETEC) each alone or in combination with E. faecium. …”
Get full text