Osteopontin at the Crossroads of Inflammation and Tumor Progression by Luigi Mario Castello, Davide Raineri, Livia Salmi, Nausicaa Clemente, Rosanna Vaschetto, Marco Quaglia, Massimiliano Garzaro, Sergio Gentilli, Paolo Navalesi, Vincenzo Cantaluppi, Umberto Dianzani, Anna Aspesi, Annalisa Chiocchetti

“…OPN is overexpressed in several human carcinomas and has been implicated in inflammation, tumor progression, and metastasis. …”
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Image Digitization of Colorimetric Detection of Acephate Based on Its Complexation with Citrate-Capped Gold Nanoparticles by Mohd Junaedy Osman, Wan Md Zin Wan Yunus, Keat Khim Ong, Buong Woei Chieng, Noor Azilah Mohd Kassim, Siti Aminah Mohd Noor, Victor Feizal Knight, Jahwarhar Izuan Abd Rashid, Chin Chuang Teoh

“…Acephate (Ac), an organophosphate (OP) insecticide, is very harmful to human and the environment. Conventional techniques of detection are sensitive and selective but relatively time-consuming, expensive, and require trained personnel. …”
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Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of High-Dose Autologous CD34+ Bone Marrow Mononuclear Cells by Joseph C. Poole, Arshed A. Quyyumi

“…Indeed, the past decade has been marked by a number of human trials studying the safety and efficacy of progenitor cell delivery in the post-STEMI setting. …”
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Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine by Monika Wojtyłko, Ariadna B. Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach, Oliwia Kordyl, Antoni Białek, Julia Krysztofiak, Tomasz Osmałek, Dimitrios A. Lamprou

“…The optimized formulations were subjected to spectroscopic and rheological characterization and mechanical tests, as well as tested for release through an artificial membrane and permeation through human skin ex vivo. Both hydrogels were found to have suitable parameters for coating microneedles using the dip-coating method, including the stability of the substance at the process temperature, shear-thinning behavior, and appropriate textural parameters such as adhesion or hardness. …”
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Roquefort Cheese Proteins Inhibit Chlamydia pneumoniae Propagation and LPS-Induced Leukocyte Migration by Ivan M. Petyaev, Naylia A. Zigangirova, Natalie V. Kobets, Valery Tsibezov, Lydia N. Kapotina, Elena D. Fedina, Yuriy K. Bashmakov

“…We report that a proprietary protein extract isolated from Roquefort cheese inhibits the propagation of C. pneumoniae in a human HL cell line in a dose-dependent manner, as revealed by the immunofluorescence analysis. …”
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Evaluating the Polyphenol Profile in Three Segregating Grape (Vitis vinifera L.) Populations by Alberto Hernández-Jiménez, Rocío Gil-Muñoz, Yolanda Ruiz-García, Jose María López-Roca, Adrián Martinez-Cutillas, Encarna Gómez-Plaza

“…Among the intraspecific crosses, plants with grapes presenting very high concentrations of anthocyanins and flavonols were found, indicating a transgressive segregation for this character, and this could lead to highly colored wines with an increased benefits for human health. As regards the qualitative composition of anthocyanins and flavonols, the hydroxylation pattern of the hybrids that also may influence wine color hue and stability presented intermediate values to those of the parentals, indicating that values higher than that showed by the best parental in this respect will be difficult to obtain. …”
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Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia by Dominique Dardevet, Didier Rémond, Marie-Agnès Peyron, Isabelle Papet, Isabelle Savary-Auzeloux, Laurent Mosoni

“…However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. …”
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Unveiling the Influencing Factors of the Residual Life of Historical Buildings: A Study of the Wuhan Lutheran Missions Home and Agency Building by Bo Huang, Xueqi Liu, Lanjun Liu, Zhiyong Li, Zhifeng Wu, Bin Huang, Zimo Jia

“…The development of a city needs the accumulation of culture, and historical buildings are the most direct witness of the rise and fall of a city. Like the human body, historical buildings have a certain life cycle, but the acceleration of urbanization and unreasonable use cause an irreversible reduction in the remaining life of historical buildings. …”
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Wpływ emisji energii z terenów zurbanizowanych i szlaków komunikacyjnych na zmiany w rozwoju ekosystemów w ich otoczeniu by Urszula Kaźmierczak, Andrzej Kulczycki

“…This article aims to draw attention to the hitherto unexplored and scarcely noticed the problem of the effects of the consumption of increasing amounts of energy to human health and ecosystems exposed to emissions processed in the phase of energy consumption. …”
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The Barcelona Historical Marriage Database and the Baix Llobregat Demographic Database. From Algorithms for Handwriting Recognition to Individual-Level Demographic and Socioeconomi... by Joana Maria Pujadas-Mora, Alícia Fornés, Oriol Ramos Terrades, Josep Lladós, Jialuo Chen, Miquel Valls-Fígols, Anna Cabré

“…However, its current state still requires some human intervention which explains the implemented crowdsourcing and game sourcing experiences. …”
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Evaluation of Mathematical Modeling Activities of 4th-Grade Students: The Case of Experiential Learning Theory by Gülcenur Kesebir, Dilara Yılmaz

“…The story about a virus facing humanity asked to the students to find a solution of the problem. …”
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Effects of Weather Conditions on Phenolic Content and Antioxidant Capacity in Juice of Chokeberries (Aronia melanocarpa L.) by Tolić Mandica-Tamara, Krbavčić Ines Panjkota, Vujević Predrag, Milinović Bernardica, Jurčević Irena Landeka, Vahčić Nada

“…This study indicates that although the examined properties vary considerably through the growing seasons (p≤0.05), chokeberry juices can serve as a good source of bioactive phytochemicals in a human diet.…”
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Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review by Wierzejska Regina

“…The question whether coffee has a negative or a positive impact on human health has been the topic of much heated debate for years. …”
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Secukinumab-Induced Inflammatory Bowel Disease in a Patient Treated for Chronic Plaque Psoriasis and Psoriatic Arthritis: A Case Report and Review of the Role of Novel Biologic Age... by K. M. Darch, T. L. Holland, L. J. Spelman

“…Secukinumab (Cosentyx), a fully-human monoclonal antibody that acts by selectively binding to and neutralising the proinflammatory cytokine IL-17A, is used widely for the treatment of both chronic plaque psoriasis and psoriatic arthritis. …”
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Sinonasal Melanoma: A Case Report and Literature Review by I. S. S. Alves, L. G. S. Berriel, R. T. Alves, M. B. Pinto, C. F. P. Oliveira, A. C. Cazzotto, W. V. Moura

“…Immunochemical analysis revealed positivity for vimentin, S100, and HMB-45 (human melanoma black 45), a result compatible with a diagnosis of malignant melanoma. …”
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New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases by Annika Willitzki, Rico Hiemann, Vanessa Peters, Ulrich Sack, Peter Schierack, Stefan Rödiger, Ursula Anderer, Karsten Conrad, Dimitrios P. Bogdanos, Dirk Reinhold, Dirk Roggenbuck

“…Due to lacking automation, standardization, modern data management, and human bias in IIF screening, this two-stage approach has recently been challenged by multiplex techniques particularly in laboratories with high workload. …”
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Biologically Inspired Spatial–Temporal Perceiving Strategies for Spiking Neural Network by Yu Zheng, Jingfeng Xue, Jing Liu, Yanjun Zhang

“…Moreover, this perceptual process needs to be interpretable and understandable, so that future interactions between unmanned systems and humans can be unimpeded. However, current mainstream DNN (deep learning neural network)-based AI (artificial intelligence) is a ‘black box’. …”
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Innate and Adaptive Immunity in Calcific Aortic Valve Disease by Patrick Mathieu, Rihab Bouchareb, Marie-Chloé Boulanger

“…The expression of TNF-α and IL-6 is increased in human mineralized aortic valves and promotes an osteogenic program as well as the mineralization of valve interstitial cells (VICs), the main cellular component of the aortic valve. …”
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The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring by Luyue Qi, Lianyong Liu, Li Li, Weiwei Hu, Wenzhen Fu, Ji Hu, Youjia Xu, Zhenlin Zhang

“…We used dual-energy X-ray absorptiometry to measure the composition of the human body. The quantitative transmission disequilibrium test (QTDT) was used to analyze the associations of the SNPs with the body composition. …”
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Justification of the approach to identifying promising managers for project management by I. M. Kazymov, B. S. Kompaneets

“…The article deals with problems of project management in the context of a shortage of human resources at enterprises in the real sector of the economy as well as with promising areas of development to improve the efficiency of project management. …”
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