The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…ΔROP55 infection also induced RIPK3-dependent necroptosis in human and mouse primary macrophages. Moreover, ΔROP55 parasites were significantly impaired in virulence in female mice and prevented NF-κB activation and parasite clearance in mBMDM. …”
Get full text

Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway by Li Wang, Chaofan Zhang, Muhammad Azhar Memon, Qianting Shi, Le Lu, Xishuai Tong, Yonggang Ma, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan

“…Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. …”
Get full text

Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

“…Although energy transduction by glucose metabolism is the main function of this pathway, involvement in virulence, growth, pathogen–host interactions, immunomodulation and adaptation to environmental conditions are other functions attributed to this metabolic pathway. In humans, where glycolysis occurs mainly in the cytosol, the mislocalization of some glycolytic enzymes in various other subcellular locations, as well as alterations in their expression and regulation, has been associated with the development and progression of various diseases. …”
Get full text

Polymorphonuclear Leukocytes or Hydrogen Peroxide Enhance Biofilm Development of Mucoid Pseudomonas aeruginosa by Qi Tan, Qing Ai, Qi Xu, Fang Li, Jialin Yu

“…Pseudomonas aeruginosa is an opportunistic pathogenic bacterium involved in many human infections, including pneumonia, diabetic foot ulcers, and ventilator-associated pneumonia. …”
Get full text

Ecological situation in the modern Russian Federation: comparison with other countries as a basis for new ideas for the development of the state by M. S. Efremova

“…Among the necessary measures, it is worth noting the following: the introduction of a new ideology that will put in the first place the harmonious relationship between nature and a human; introduction of environmental education; a new system of preparing the specialists, including courses on an environmentally oriented lifestyle; information policy, revealing the essence of existing environmental problems; support for environmental organizations; introduction of a new approach to alternative energy and green technologies.…”
Get full text

Graph Neural Networks in Brain Connectivity Studies: Methods, Challenges, and Future Directions by Hamed Mohammadi, Waldemar Karwowski

“…Brain connectivity analysis plays a crucial role in unraveling the complex network dynamics of the human brain, providing insights into cognitive functions, behaviors, and neurological disorders. …”
Get full text

Experimental Investigation into Compressive Behaviour and Preconsolidation Pressure of Structured Loess at Different Moisture Contents by Yali Xu, Panpan Guo, Chengwei Zhu, Gang Lei, Kang Cheng

“…The Casagrande method realized through the MATLAB program can effectively eliminate human factors and accurately calculate the corresponding preconsolidation pressure for undisturbed soil. …”
Get full text

Oath-Taking, Peacebuilding and Conflict Resolution in Traditional African Society: The Izzi Example by Kelechi Johnmary Ani, Anselm Aleke Oyon

“…The reality of human history reveals the age-long traditions of different people in their quest for survival. …”
Get full text

A Comparative Analysis of Spatial Resolution Sentinel-2 and Pleiades Imagery for Mapping Urban Tree Species by Fabio Recanatesi, Antonietta De Santis, Lorenzo Gatti, Alessio Patriarca, Eros Caputi, Giulia Mancini, Chiara Iavarone, Carlo Maria Rossi, Gabriele Delogu, Miriam Perretta, Lorenzo Boccia, Maria Nicolina Ripa

“…Urbanization poses significant challenges to ecosystems, resources, and human well-being, necessitating sustainable planning. …”
Get full text

Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit by Maohua Cao, Junaid A. Khan, Bum-Yong Kang, Jawahar L. Mehta, Paul L. Hermonat

“…To investigate possible therapeutic synergism, we delivered both full-length wild-type human (h) STAT3 and hIL-10 genes by separate adenoassociated virus type 8 (AAV8) tail vein injection into LDLR KO on HCD. …”
Get full text

Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals by Ghyda Murad Hashim, Mehdi Shahgolzari, Kathleen Hefferon, Afagh Yavari, Srividhya Venkataraman

“…In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. …”
Get full text

Scattering Improves Temporal Resolution of Vision: A Pilot Study on Brain Activity by Francisco J. Ávila

“…Temporal vision is a vital aspect of human perception, encompassing the ability to detect changes in light and motion over time. …”
Get full text

Green Synthesis and Characterization of Biocompatible Gold Nanoparticles Using Solanum indicum Fruits by Punuri Jayasekhar Babu, Pragya Sharma, Sibyala Saranya, Ranjan Tamuli, Utpal Bora

“…The cytotoxicity of the synthesized AuNPs were tested on two different human cancer cell lines, HeLa and MCF‐7 and were found to be nontoxic, thus providing an opportunity to be used in biomedical applications.…”
Get full text

Efficiency of Sawdust as Low-Cost Adsorbent for Dyes Removal by R. Chikri, N. Elhadiri, M. Benchanaa, Y. El maguana

“…In recent years, the removal of dyes from wastewater has attracted considerable attention due to their harmful effects to ecosystem and human health. Adsorption as a facile and effective technique has been widely used to eliminate a large variety of dyes from aqueous solutions. …”
Get full text

DDX1 is required for non-spliceosomal splicing of tRNAs but not of XBP1 mRNA by Teruhiko Suzuki, Satoko Takagi, Junta Funada, Yuka Egawa, Mana Yamakawa, Takahiko Hara

“…To analyze the functions of DDX1 in mammalian cells, we generated DDX1 cKO cells from the polyploid human U2OS cell line and found that splicing of intron-containing tRNAs was significantly disturbed in DDX1-deficient cells, whereas endoplasmic reticulum (ER) stress-induced splicing of XBP1 mRNA was unaffected. …”
Get full text

First Report of Psoriatic-Like Dermatitis and Arthritis in a 4-Year-Old Female Spayed Pug Mix by Stephanie A. Regan, Rosanna Marsella, Ibrahim Ozmen

“…After ruling out other differential diagnoses and based on the similarity of clinical, radiographic, and histologic findings to human psoriasis and PsA, a tentative diagnosis of psoriasis-like disease was made. …”
Get full text

Posthuman Communication Design in South Africa by Katarzyna Chmela-Jones, Johannes Cronje, Bruce Snaddon

“…It addresses the dearth in research regarding the interconnectedness of Posthumanism and communication design practice, specifically aiming to bridge the gap between human-centric design solutions and the traditional commercial facets of visual communication. …”
Get full text

POLUDANUM’S INFLUENCE ON REPRODUCTIVE AND RESPIRATORY SYNDROME, TRANSMISSIBLE GASTROENTERITIS AND AFRICAN SWINE FEVER VIRUSES IN PRIMARY AND CONTINUOUS CELL CULTURES by D. V. Sharypova, I. Yu.  Zhukov, Ali  Mazlum, N. N. Vlasova, O. S. Puzankova, V. L. Gavrilova, A. S. Igolkin

“…Today studies of the influence of interferon synthesis inducer on human and animal body is a topical issue. Interferon synthesis inducers are substances of natural or artificial origin stimulating production of body’s own interferon. …”
Get full text

Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1 by Satoshi Okano

“…Moreover, male Tg mice exhibit symptoms of diabetes characterized by beta-cell dysfunction, resembling human maturity onset diabetes of the young (MODY). …”
Get full text

History and Philosophy of Science at the Crossroads of Doctoral Education’s Reforms: Polemical Notes by E. N. Ishchenko

“…The high quality of training future researchers, and focus on the development of human capital meet the challenges posed by the contemporary knowledge society.…”
Get full text