Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection by Trever T. Greene, Yeara Jo, Carolina Chiale, Monica Macal, Ziyan Fang, Fawziyah S. Khatri, Alicia L. Codrington, Katelynn R. Kazane, Elizabeth Akbulut, Shobha Swaminathan, Yu Fujita, Patricia Fitzgerald-Bocarsly, Thekla Cordes, Christian Metallo, David A. Scott, Elina I. Zúñiga

“…Mechanistically, we identify lactate dehydrogenase B (LDHB) as a positive regulator of pDC IFN-I production in mice and humans; meanwhile, LDHB deficiency is associated with suppressed IFN-I production, pDC metabolic capacity, and viral control following infection. …”
Get full text

PAIVS: prediction of avian influenza virus subtype by Hyeon-Chun Park, Juyoun Shin, Sung-Min Cho, Shinseok Kang, Yeun-Jun Chung, Seung-Hyun Jung

“…Highly pathogenic avian influenza (HPAI) viruses have caused severe respiratory disease and death in poultry and human beings. Although most of the avian influenza viruses (AIVs) are of low pathogenicity and cause mild infections in birds, some subtypes including hemagglutinin H5 and H7 subtype cause HPAI. …”
Get full text

Guiding Lights in Genome Editing for Inherited Retinal Disorders: Implications for Gene and Cell Therapy by Carla Sanjurjo-Soriano, Vasiliki Kalatzis

“…New advances in the field of genome editing using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) have provided an accurate and efficient way to edit the human genome and represent an appealing alternative for treating IRDs. …”
Get full text

Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…Organoids have revolutionized the whole field of biology with their ability to model complex three-dimensional human organs in vitro. Intestinal organoids were especially consequential as the first successful long-term culture of intestinal stem cells, which raised hopes for translational medical applications. …”
Get full text

Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…Autophagy plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. …”
Get full text

Prospects and opportunities for mussel Mytilus trossulus farming in the southern Baltic Sea (the Gulf of Gdańsk) by Sokołowski Adam, Lasota Rafał, Alias Izabela Sami, Piłczyńska Joanna, Wołowicz Maciej

“…The cost-benefit analysis revealed a negative budget balance of production for human consumption, with a total income covering only 12.0% of the cumulative costs. …”
Get full text

Population aging: a look from nursing practice based on the Nola J. Pender model by María de los Ángeles Villegas Dorticós, Zenia Tamara Sánchez García, Omayda Urbina Laza, Noel Alberto Pardillo Mustelier, Jacquelin Cordero Odery, Maydelis Gómez Valdivia

“…Health promotion motivated by the desire to increase well-being and update human potential is currently considered a powerful tool that allows promoting attitudes, motivations and actions based on the concept of self-efficacy, the commitment of individuals to change of behaviors to promote health, not only about aging itself, but from aging. …”
Get full text

Synthesis of pyranopyrazolo N-glycoside and pyrazolopyranopyrimidine C-glycoside derivatives as promising antitumor and antimicrobial agents by Hafez Hend N., El-Gazzar Abdel-Rhman B. A.

“…N-(β-D-ribofuranosyl)- and N-(β-D-xylofuranosyl)-6{[(1E)-4-chlorophenyl)-methylene] amino}4-(4-florophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile (6a,b) were the most active compounds against three human cancer cell lines. Also, most of the newly synthesized compounds exhibited high activity towards Gram-negative and Gram-positive bacteria. …”
Get full text

Peculiarities of Chickpea Growing Technology in the Steppe Zone of Ukraine by Zhuk Mykola, Rudenko Viacheslav, Khodjibekov S.

“…Its grain is widely used in human nutrition, especially in countries such as Turkey, Israel and other Middle Eastern countries. …”
Get full text

Developing Halal Tourism Based on Local Wisdom in Religious Area of Sis Aljufri by Suhri Hanafi, Nadia Nadia, Muhammad Syarif Nurdin, Sitti Nurkhaerah, Zaiton Osman

“…The study reveals that the development of halal tourism in this area can be categorized into four aspects: products and services, government support, human resources, and infrastructure. While the development of tourist attractions aligns with the general principles of Sharia tourism and guidelines related to tourists and destinations, facilities such as hotels and travel agencies still need to meet the required Sharia-compliant standards. …”
Get full text

Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases by Ali Haydar Eskiocak, Birgul Ozkesici, Soner Uzun

“…Although there is some evidence pointing towards a genetic predisposition by some human leukocyte antigen (HLA) genes, familial occurrence of PV is very rare. …”
Get full text

Mononuclear Aluminum–Fluoride Ions, AlF<i>_x</i>^(+/−)—Study of Plausible Frameworks of Complexes with Biomolecules and Their In Vitro Toxicity by Anja Pavlovič, Larisa Janžič, Lucija Sršen, Andreja Nataša Kopitar, Kathleen F. Edwards, Joel F. Liebman, Maja Ponikvar-Svet

“…The importance of fluorine and aluminum in all aspects of daily life has led to an enormous increase in human exposure to these elements in their various forms. …”
Get full text

NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. by Harikrishnan Balachandran, Kyle Kroll, Karen Terry, Cordelia Manickam, Rhianna Jones, Griffin Woolley, Tammy Hayes, Amanda J Martinot, Ankur Sharma, Mark Lewis, Stephanie Jost, R Keith Reeves

“…To address this deficit, we employed a validated experimental NK cell depletion non-human primate (NHP) model with SARS-CoV-2 Delta variant B.1.617.2 challenge. …”
Get full text

Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells by Gregory M. Kelly, Mohamed I. Gatie

“…Another major focus is on the epigenetic regulation of ECCs and stem cells, and, towards that end, this review closes on what we see as a new frontier in combating aging and human disease, namely, how cellular metabolism shapes the epigenetic landscape and hence the pluripotency of all stem cells.…”
Get full text

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases by César Pacheco-Tena, Susana Aideé González-Chávez

“…Both roles are not mutually exclusive. Some examples in human disease and in animal models are provided based on current evidence.…”
Get full text

Induction of Interleukin-8 from Nasal Epithelial Cells during Bacterial Infection: The Role of IL-8 for Neutrophil Recruitment in Chronic Rhinosinusitis by Bit-Na Yoon, Nan-Geum Choi, Hyun-Sun Lee, Kyu-Sup Cho, Hwan-Jung Roh

“…The expression of CD11b/CD18 on neutrophils and E-selectin/ICAM-1 on endothelial cells and the adherence between neutrophils and human umbilical vascular endothelial cells (HUVECs) were determined by flow cytometric analysis, ELISA, and RIA, respectively. …”
Get full text

Understanding the Anticontagion Process and Reopening of China during COVID-19 via Coevolution Network of Epidemic and Awareness by Lingbo Li, Ying Fan, An Zeng, Zengru Di

“…Through an empirical analysis based on large-scale data and simulation based on a metapopulation and multilayer network model, we ascertain the impact of human movements and awareness diffusion on the epidemic, elucidate the inherent patterns and effective interventions of different epidemic prevention methods, and highlight the crunch time of each measure. …”
Get full text

Optimal Location of Biogas Plants in Supply Chains under Carbon Effects: Insight from a Case Study on Animal Manure in North Dakota by Yong Shin Park, Joseph Szmerekovsky, Alan Dybing

“…Faced with increasing concerns over the negative environmental impact due to human and industrial activities, biomass industry practitioners and policy makers have great interest in green supply chains to reduce carbon emissions from supply chain activities. …”
Get full text

Presence of organochlorines in water and oysters Crassostrea sp. in Cananeia-SP by Cláudia Simões Reigada, Luiz Carlos Luchini, Edison Barbieri

“…Being a place of great ecological importance in the ecosystem, the Cananeia estuarine lagoon complex presents several aquatic environments subject to contamination by human activities. Within this region were chosen four collection points and bodies of water, with some changes on the board by the shell fishermen, due to the seasons, as in winter there is a decrease in the production of oysters. …”
Get full text

Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations by Irene Riezzo, Natascha Pascale, Raffaele La Russa, Arcangelo Liso, Monica Salerno, Emanuela Turillazzi

“…The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. …”
Get full text