National and regional aspects of formation of physical culture and recreation environment in educational institutions of the Republic of Tatarstan by Manurov, Ilgiz M., Kalmanovich, Vladimir L.

“…The sports and recreation environment is a broad sphere imbued with the values of humanity and an abundance of educational opportunities. …”
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Self‐Driving Lab for Solid‐Phase Extraction Process Optimization and Application to Nucleic Acid Purification by Sebastian Putz, Jonathan Döttling, Tim Ballweg, Andre Tschöpe, Vitaly Biniyaminov, Matthias Franzreb

“…Through the integration of robotics, machine learning, and data‐driven experimentation, the SDL demonstrates a highly accelerated process optimization with minimal human intervention. In the multistep purification approach, the system is able to optimize buffer compositions for DNA extraction from complex samples, demonstrating effectiveness in both conventional chaotropic salt‐based methods and innovative chaotropic salt‐free buffers. …”
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Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity by Martin Regensburger, Iryna Prots, Beate Winner

“…The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis. …”
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A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η1-C2H4OMe)(DMSO)(phen)]+ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells... by Federica De Castro, Erika Stefàno, Erik De Luca, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Recently, a novel Pt(II) complex, [Pt(ƞ1-C2H4OMe)(DMSO)(phen)]+ (phen =  1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight human cancer cell lines. Pt-EtOMeSOphen showed higher cytotoxic effects than cisplatin in most of the cancer cell lines and in particular against the neuroblastoma cell line (SH-SY5Y). …”
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A Bichannel Transformer with Context Encoding for Document-Driven Conversation Generation in Social Media by Yuanyuan Cai, Min Zuo, Qingchuan Zhang, Haitao Xiong, Ke Li

“…We evaluate the proposed BCTCE by both automatic evaluation and human judgment. The experimental results on the dataset CMU_DoG indicate that the proposed model yields significant improvements over the state-of-the-art baselines on most of the evaluation metrics, and the generated responses of BCTCE are more informative and more relevant to dialogues than baselines.…”
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The Role of Digital Feedback on the Self-Esteem of Digital Natives by Şakir Güler, Murat Sezgin

“…The development of web technologies makes virtual platforms as an inseparable part of human life. This situation makes digital feedback highly effective on the self-esteem of individuals. …”
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Classification of Genes Based on Age-Related Differential Expression in Breast Cancer by Gunhee Lee, Minho Lee

“…As clinical transcriptome data have accumulated significantly, we classified all human genes based on age-specific differential expression between normal and breast cancer cells using public data. …”
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Form over Substance: Possibilities to Prove Electoral Irregularities under Serbian Law by Jelena Jerinić

“…Besides Serbian legislation and case law, the analysis leans on the relevant European standards, including the case law of the European Court of Human Rights. The results show that in practice, electoral commissions and courts use a limited circle of means of evidence and that the evidence submitted by complainants is not evaluated in the same way as the one coming from electoral boards. …”
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Genome Stability Pathways in Head and Neck Cancers by Glenn Jenkins, Kenneth J. O'Byrne, Benedict Panizza, Derek J. Richard

“…Variable functionality of an increasing spectrum of repair gene polymorphisms is associated with increased cancer risk, while aetiological factors such as human papillomavirus, tobacco and alcohol induce significantly different behaviour in induced malignancy, underpinned by differences in genomic stability. …”
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Ukraine-Russian Federation Relations within the Concepts of Security Dilemma and Responsibility To Protect (R2P) by Tuba Taşlıcalı Koç

“…Since the early ages of history, the need to feel safe in human beings has emerged and the instinct to act collectively for the purpose of self-protection has settled. …”
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Exploring Logical Intuition in Base-Rate Problems Using the Instructional Manipulation Paradigm by Debiao Zhu, Ping Lu, Zhujing Hu, Jianyong Yang, Dandan Nie

“…The study provides additional evidence for human rationality.…”
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Biofilm Compositions and Bacterial Diversity on Kitchen Towels in Daily Use by Yao Zhang, Kexin Li, Yibo Ru, Yue Ma

“…<i>Kocuria</i>, <i>Rothia</i>, <i>Psychrobacter</i>, <i>Enhydrobacter</i>, and <i>Pseudomonas</i> are genera of relatively high abundance that may originate from the human body and foods. In addition, correlations among environmental factors, major bacterial genera, physical properties, and biofilm formation of the towels were analyzed, which could provide a scientific reference for maintaining towel hygiene.…”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Although underscored by animal studies, the endotypes of human RDEB are poorly understood. To fill this gap, we apply systems immunology approaches using single-cell high-dimensional techniques to capture the signature of peripheral immune cells and the diversity of metabolic profiles in RDEB adults, sampled outside of any opportunistic infection and active cancer. …”
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Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons by Bianca Seifert, Robert Eckenstaler, Raik Rönicke, Julia Leschik, Beat Lutz, Klaus Reymann, Volkmar Lessmann, Tanja Brigadski

“…Transport of BDNF was altered at a very early time point after onset of human APP expression or after acute amyloid-beta(1-42) treatment, while the activity-dependent release of BDNF remained unaffected. …”
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Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity by Dwaine F. Emerich, Jeffrey H. Kordower, Yaping Chu, Chris Thanos, Briannan Bintz, Giovanna Paolone, Lars U. Wahlberg

“…Methods. Human ARPE-19 cells engineered to secrete high levels of the glial cell line-derived neurotrophic factor (GDNF) were encapsulated into hollow fiber membranes. …”
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Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo by Liang Gongwen, Li Na, Ma Liping, Qian Zhonglian, Sun Yuwen, Shi Luwen, Zhao Libo

“…The aim of this study was to identify an effective flavonoid that could improve the intracellular accumulation of ritonavir in human brain-microvascular endothelial cells (HBMECs). …”
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The lingering menace: How legacy organochlorine pesticides still threaten our rivers and food chains by Wenping Xie, Guangjun Wang, Ermeng Yu, Jun Xie, Wangbao Gong, Zhifei Li, Kai Zhang, Yun Xia, Jingjing Tian, Hongyan Li

“…The bioaccumulation of organochlorine pesticides (OCPs) in aquatic organisms has been extensively explored in recent years due to associated ecological risks and potential threats to human health through food. This study aims to assess the bioaccumulation of organochlorine pesticides (OCPs) in 18 freshwater fish species from the Pearl River Delta, China. …”
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Oxygenation of the Intraportally Transplanted Pancreatic Islet by Thomas M. Suszynski, Efstathios S. Avgoustiniatos, Klearchos K. Papas

“…At our institutions, large human alloislets (>200 μm diameter) account for ~20% of total islet number but ~70% of total islet volume; since most of the total transplanted islet volume is accounted for by large islets, most of the intraportal islet cells are likely to be anoxic and not fully functional.…”
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Prednisone inhibits osteosarcoma cell by regulating the Wnt/β-catenin signaling pathway by Yo Zhang, Hongmei Zhang, Shanshan Yang, Xiufeng Gao, Wenhao Guo

“… Prednisone, a synthetic glucocorticoid, possesses a moderate duration of action in the human body. To investigate the effect of prednisone on osteosarcoma cells in vitro, CCK8, wound healing, Transwell assays, flow-cytometry, western blot, and ELISA were used to measure cell proliferation, cell migration, cell invasion, cell cycle, cell apoptosis, and the key proteins in Wnt/β-catenin pathway. …”
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Investigating Stability Problems in Solid Waste Landfills by Gökçe Buse Güner Karaca, Şeyma Ordu, Ertuğrul Ordu

“…The quality of groundwater has been seriously compromised due to improper storage methods. Problems related to human health and environmental pollution are more common in open dumps. …”
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