The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control by Jean-Philippe Guégan, Christophe Frémin, Georges Baffet

“…In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.…”
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Noninvasive Techniques for Management of Erythema Multiforme by Fabiana Martins, Debora Pallos, Jodkandlys Candeia, Rodrigo Zerbinati, Paulo Henrique Braz-Silva, Luana Campos

“…The laboratory findings included serum positivity for the Epstein-Barr virus, and salivary tests showed positive values for herpes simplex virus (HSV-2) and human herpesvirus (HHV-7). The diagnostic hypothesis was based on clinical findings and viral infection detected in the saliva, which triggered an immunological disorder, that is, erythema multiforme (EM). …”
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The effect of a learning approach based on experience and prior knowledge on the mastery of the concept of static fluids by Nadrah Nadrah

“…These natural phenomena can occur at any time without being realized by humans. This study aims to determine the difference in concept mastery between students who are taught with an experiential learning approach and students who are taught using a conventional approach to class XI Science at SMA Negeri 2 Makassar in the 2020/2021 academic year, to determine the differences in conceptual mastery between students who have high and low initial knowledge. …”
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Enteric coating of granules containing the probiotic Lactobacillus acidophilus by Pyar Hassan, Peh Kok-Khiang

“…In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestine…”
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Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Epigenetic mechanisms play a role in human disease but their involvement in pathologies from the central nervous system has been hampered by the complexity of the brain together with its unique cellular architecture and diversity. …”
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Recent catalytic advances in the production of adipic acid and its esters from bio-based C6 molecules and carbon dioxide by Dinesh Kumar Mishra, Cong Chien Truong, Yeongin Jo, Young-Woong Suh

“…Adipic acid (AA), used in the manufacture of nylon-6,6, polyurethane, and plasticizers, is derived from multi-stage processing of petrochemical resources, posing serious harms to human being and environment. Owing to the recent mounting concern over carbon footprint, the establishment of AA and its esters from renewable bio-based C6 molecules and carbon dioxide (CO2) has come into the limelight. …”
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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

“…Here we show that when directly added to a cell culture, 12mer guanine RNA (G12) and its phosphorothioate-linked derivatives (G12(S)), rapidly entered cytoplasm and suppressed the propagation of human coronaviruses and influenza A viruses to between 1/100 and nearly 1/1000 of normal virus infectivity without cellular toxicity and induction of innate immunity. …”
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Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin by Nádia Bertoncello, Roseli Peres Moreira, Danielle Yuri Arita, Danielle S. Aragão, Ingrid Kazue Mizuno Watanabe, Patricia S. Dantas, Ralmony Santos, Rodolfo Mattar-Rosa, Rodrigo Yokota, Tatiana Sousa Cunha, Dulce Elena Casarini

“…Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. …”
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Production, Characterization, and Sensory Profiling of Novel Pepper Distilled Spirit by Yap Chin Ann, Foo See Wei, Gilbert Yeo, Teow Wei Ping, Lawrence Tuah

“…In conclusion, pepper berries can be used as raw material for pepper whiskey production and having organoleptic quality acceptable for human consumption.…”
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Skeletal Muscle Mitochondria and Aging: A Review by Courtney M. Peterson, Darcy L. Johannsen, Eric Ravussin

“…Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched. Animal and human studies typically show that skeletal muscle mitochondria are altered with aging, including increased mutations in mitochondrial DNA, decreased activity of some mitochondrial enzymes, altered respiration with reduced maximal capacity at least in sedentary individuals, and reduced total mitochondrial content with increased morphological changes. …”
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Comparing student mobility pattern models by Marie-Louise Litmeyer, Philipp Gareis, Stefan Hennemann

“…However, in recent years, a number of new models, such as radiation models, have been introduced to estimate human mobility. The focus has generally been on models dealing with commuting movements. …”
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In silico modelling of organ-on-a-chip devices: an overview by Yue Wang, Lucia Marucci, Lucia Marucci, Lucia Marucci, Martin E. Homer

“…An organ-on-a-chip (OOAC) is a microscale device designed to mimic the functions and complexity of in vivo human physiology. Different from traditional culture systems, OOACs are capable of replicating the biochemical microenvironment, tissue-tissue interactions, and mechanical dynamics of organs thanks to the precise control offered by microfluidic technology. …”
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Privacy preservation in data intensive environment by Jyotir Moy Chatterjee, Raghvendra Kumar, Prasant Kumar Pattnaik, Vijender Kumar Solanki, Noor Zaman

“…Healthcare data frameworks have enormously expanded accessibility of medicinal reports and profited human services administration and research work. …”
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Magnetic micro-protrusion arrays with wrinkled polypyrrole surfaces for enhancing the performance of flexible pressure sensors by Ruixue Sun, Jie Lu, Pei Li, Pingan Yang, Jianchun Jiang, Mengjie Shou, Changrong Liao

“…On this basis, sensing arrays and grip strength tests were performed to accelerate practical development, and these sensors were integrated into smart insoles for fall detection early warning, demonstrating their potential applications in wearable devices, smart homes, and human health monitoring.…”
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Corticomuscular Activity Modeling by Combining Partial Least Squares and Canonical Correlation Analysis by Xun Chen, Aiping Liu, Z. Jane Wang, Hu Peng

“…Corticomuscular activity modeling based on multiple data sets such as electroencephalography (EEG) and electromyography (EMG) signals provides a useful tool for understanding human motor control systems. In this paper, we propose modeling corticomuscular activity by combining partial least squares (PLS) and canonical correlation analysis (CCA). …”
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A study of the propensity for communicative aggressiveness in cadet pilots by M. V. Erkhova, I. Sh. Aizatullova

“…This technique is designed to assess a person’s predisposition to aggression in various situations and contains 11 parameters of explicit and hidden forms of aggressive human behaviour. The article substantiates the relevance of studying communicative aggressiveness as a professional destruction of civil aviation pilots. …”
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Offline English Handwritten Character Recognition using Sequential Convolutional Neural Network by Muhammad Iqbal, Muniba Humayun, Raheel Siddiqi, Christopher J. Harrison, Muneeb Abid Malik

“…The idea is to make the machine recognize handwritten human characters. The language focused in this research paper is English while using offline handwritten character recognition for identifying English characters. …”
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Design and Evaluation of Photo-Induced Biofeedback Fabric for the Enhancement in Sleeping Sense by Wei-Cheng Chu, Hsin-Ju Lin, Shu-Ping Chiu

“…The results were shown that human’s brain wave can be changed from sober status to shallow-sleeping status and the effect of enhancing sleeping sense can be achieved for all pattern layers in frequencies of 0, 5 and 10 Hz. …”
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A time-varying index for agricultural suitability across Europe from 1500–2000 by Alexander Lehner, Dylan Philippe

“…It will empower researchers to explore the interplay between climatic fluctuations and Europe’s agricultural landscape, analyze human responses at a local and regional scale, and foster a deeper understanding of the region’s historical dynamics.…”
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Biofilm-associated proteins: from the gut biofilms to neurodegeneration by Jaione Valle

“…Human microbiota form a biofilm with substantial consequences for health and disease. …”
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