Regulation of body temperature and blood pressure in women: Mechanisms and implications for heat illness risk by Gabrielle E. W. Giersch, Nisha Charkoudian

“…Mechanisms controlling blood pressure and body temperature have substantial overlap in humans, largely due to autonomic mechanisms which contribute to both. …”
Get full text

Learning models innovation in industrial revolution 4.0 era by Metsa Fajrianti Kusumah Suwandi, Muhammad Alfat

“…The study results show that the Industrial Revolution 4.0 era resulted in changes in human life patterns due to the influence of technological devices. …”
Get full text

Educational Migration of Applicants Among Regions of the Russian Federation as a Data Source for Planning the Higher Education System Development by A. V. Dozhdikov, E. V. Kornilova

“…The practical problems of the study are focused on the creation of analytical conditions for decision-making and planning for the education system development: the distribution of enrollment targets, financing and resource supporting the infrastructure development, and the development of the human resources potential of Russian universities. …”
Get full text

Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Abstract Bacterial infections pose a significant threat to human health. Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as a promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. …”
Get full text

Embracing generative artificial intelligence: The perspectives of English instructors in Thai higher education institutions by Lucas Kohnke, Mark B. Ulla

“…The participants emphasised that human instructors were still needed, although their roles needed to evolve. …”
Get full text

Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation by Sonia Aristin Revilla, Cynthia L. Frederiks, Stefan Prekovic, Enric Mocholi, Onno Kranenburg, Paul J. Coffer

“…High expression of genes upregulated in CRC organoid-induced Treg cells correlates with shorter progression-free intervals and overall survival in CRC patients. Human CRC organoids similarly induced Treg cells with enhanced suppressive capacity and upregulated genes linked to CRC Treg cells in vivo. …”
Get full text

Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

“…In line with these observations, an increased c-Abl activation is reported in human neurodegenerative pathologies, such as Parkinson’s, and Alzheimer’s diseases. …”
Get full text

Obscenity Detection Using Haar-Like Features and Gentle Adaboost Classifier by Rashed Mustafa, Yang Min, Dingju Zhu

“…This only fact may lead to many false images having skin-like objects and may not detect those images which have partially exposed skin area but have exposed erotogenic human body parts. This paper presents a novel method for detecting nipples from pornographic image contents. …”
Get full text

Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling by Preeti Dubey, Yingye Fang, K. Lionel Tukei, Shobhan Kuila, Xinming Liu, Annika Sahota, Antonina I. Frolova, Erin L. Reinl, Manasi Malik, Sarah K. England, Princess I. Imoukhuede

“…To address this, we developed a mathematical model examining the effects of five OXT receptor (OXTR) variants (V45L, P108A, L206V, V281M, and E339K) on OXT–OXTR binding dynamics in human embryonic kidney cells (HEK293T) and myometrial smooth muscle cells. …”
Get full text

Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 by Mark A Wainberg, Ronald Rooke, Michel Tremblay, XuGuang Li, Michael A Parniak, Qing Gao, Xiao-Jian Yao, Chris Tsoukas, JSG Montaner, M Fanning, J Ruedy

“…A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. …”
Get full text

An IoT and Machine Learning-Based Model to Monitor Perishable Food towards Improving Food Safety and Quality by Amina Batool, Souvik Ganguli, Hashem Ali Almashaqbeh, Muhammad Shafiq, A. L. Vallikannu, K. Sakthidasan Sankaran, Samrat Ray, F. Sammy

“…Additionally, it safeguards food imported from other nations by confirming that it is safe for human consumption before it is released. This article describes a technique for monitoring perishable goods that is based on the Internet of Things and machine learning. …”
Get full text

Feline Papillomatosis by Herman Egberink, Katrin Hartmann, Ralf Mueller, Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Karin Möstl, Diane D. Addie, Corine Boucraut-Baralon, Tadeusz Frymus, Regina Hofmann-Lehmann, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Margaret J. Hosie

“…Besides cat-specific PVs, DNA sequences most closely related to human and bovine PVs have been detected in feline skin lesions. …”
Get full text

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain by Geeta Ramesh, Andrew G. MacLean, Mario T. Philipp

“…This review will focus on how cytokines and chemokines affect neuroinflammation and disease pathogenesis in bacterial meningitis and brain abscesses, Lyme neuroborreliosis, human immunodeficiency virus encephalitis, and neuropathic pain.…”
Get full text

Computational thinking for young indigenous learners in New Zealand by Wendy Fox‐Turnbull, Shaoqun Wu, Tiana Mayo, Matthew Stafford, Swati Gulati

“…Abstract Computational thinking, a key component for digital technologies, is defined as an approach to problem‐solving, designing computer systems, and understanding related human behaviours, while drawing on fundamental ideas of computing. …”
Get full text

Configuration Synthesis and Performance Analysis of Finger Soft Actuator by Ziqiang Zhang, Hanlong Chen, Zining Zhang

“…The configuration synthesis method for soft actuator was proposed based on the analysis of the physiological structure of the finger, and the soft actuator can make the human-machine closed-loop structure including n joints (n=1, 2, 3) meet the requirement of DOF (degrees of freedom). …”
Get full text

<i>Helicobacter pylori</i> HP0135 Is a Small Lipoprotein That Has a Role in Outer Membrane Stability by Doreen Nguyen, Rachel G. Ivester, Kyle Rosinke, Timothy R. Hoover

“…<i>Helicobacter pylori</i> is a Gram-negative bacterium and human pathogen that is linked to various gastric diseases, including peptic ulcer disease, chronic gastritis, and gastric cancer. …”
Get full text

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability by Emily Graham, Lucia Rampazzo, Chin Wei Brian Leung, Jacob Wall, Emőke Zsanett Gerőcz, Mikhail Liskovykh, Nikolay Goncharov, Xanita Saayman, Ramazan Gundogdu, Masato T. Kanemaki, Hiroshi Masumoto, Vladimir Larionov, Natalay Kouprina, Fumiko Esashi

“…We find that BRCA2, but not PALB2, is essential for maintaining a human artificial chromosome. In native chromosomes, BRCA2 ensures CENP-A occupancy and prevents DNA fragility at centromeres. …”
Get full text

Perspectives on Clinical Informatics: Integrating Large-Scale Clinical, Genomic, and Health Information for Clinical Care by In Young Choi, Tae-Min Kim, Myung Shin Kim, Seong K. Mun, Yeun-Jun Chung

“…The widespread adoption of EMR systems and the completion of the Human Genome Project developed the technologies for data acquisition, analysis, and visualization in two different domains. …”
Get full text

Spatial/Temporal Characterization and Risk Assessment of Trace Metals in Mangla Reservoir, Pakistan by Muhammad Saleem, Javed Iqbal, Gulraiz Akhter, Munir H. Shah

“…Probable risk associated with the metals levels on human health was also evaluated using hazard quotients (HQ) by ingestion and dermal routes for adults and children. …”
Get full text

Aflatoxin B1-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae by Michael Fasullo, Yifan Chen, William Bortcosh, Minzeng Sun, Patricia A. Egner

“…AFB1 exposure induces RAD51 expression and triggers Rad53 activation in yeast cells that express human CYP1A2. It was unknown, however, when and if Rad51 foci appear. …”
Get full text