TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

“…MTAP deletion occurs in 10–15 % of all human cancer representing multiple histologies. MTA is a negative regulator of PRMT5 that accumulates as a result of MTAP deletion. …”
Get full text

An Integrative Approach to Accurate Vehicle Logo Detection by Hao Pan, Bailing Zhang

“…A fast and reliable vehicle logo detection approach is proposed following visual attention mechanism from the human vision. Two prelogo detection steps, that is, vehicle region detection and a small RoI segmentation, rapidly focalize a small logo target. …”
Get full text

Explosion Flame and Pressure Characteristics of Nonstick Coal Dust and the Inhibition of Explosion Suppressants by Tianqi Liu, Ruiheng Jia, Xiaoting Dong, Xuan Zhao, Weiye Tian, Zhixin Cai, Ning Wang

“…Nonstick coal is widely distributed in the world and is an important resource for human beings. The explosion characteristics and explosion suppression of nonstick coal dust are increasingly concerning. …”
Get full text

La Seguridad en la Producción de Alimentos en la Granja: Buenas Prácticas Agrícolas y Buenas Prácticas de Manejo – Sanidad en las Instalaciones de Empaque by Federico G. Caro, Alexandra Chang, Renée M. Goodrich-Schneider, Keith R. Schneider

“…Schneider, and published by the UF Department of Food Science and Human Nutrition, February 2013.  http://edis.ifas.ufl.edu/topic_series_spa_food_safety_on_the_farm  http://edis.ifas.ufl.edu/fs219   …”
Get full text

Occurrence of Surface Active Agents in the Environment by Ewa Olkowska, Marek Ruman, Żaneta Polkowska

“…Due to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). After using and discharging from wastewater treatment plants as effluent stream, surface active agents (SAAs) are emitted to various elements of the environment (atmosphere, waters, and solid phases), where they can undergo numerous physic-chemical processes (e.g., sorption, degradation) and freely migrate. …”
Get full text

THE SANDY HILL LANDSCAPE (CORRIENTES, ARGENTINA) FROM LATE PLEISTOCENE TO THE PRESENT by Félix Ignacio Contreras, Silvina Andrea Contreras, Cecilia Romina Méndez, Mariana Noemí Baruzzo, Elsie Araseli Ojeda, Ivana Evelin Kovalsky

“…The landscape is the sum of natural and human elements. The presence of these elements, their distribution and interaction are combined throughout time to give shape to a particular place. …”
Get full text

Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…Our results may help to clarify the role of inflammations on RA development and imply that blocking NF-κB activation may be partly beneficial for human RA therapy. These findings might provide a mechanism-based rationale for developing new strategy to RA clinical therapy.…”
Get full text

GLOBALIZATION AND HIGHER EDUCATION: A WAY TO THE GLOBAL CITIZENSHIP OR LOSS OF NATIONAL IDENTITY by T. L. Oskolova

“…As an alternative to the existing pragmatic approach, the author puts forward the multicultural educational paradigm which is a culture relevant, valuebased system of moral and civil education focused on preservation of unique national features and simultaneous development of universal human values. The research objectives include critical evaluation of the USA experience, regarding the advantages and disadvantages of commercialized education; and identification of the pragmatic approach consequences in Russia, such as unification and simplification of education, and negative impact on the cultural and national identity formation. …”
Get full text

COAST-ES: Herramienta integral de tamizaje para adultos mayores by Karima Alabasi, Nancy J. Gal, Wendy Dahl, Daniela Rivero Mendoza

“…Dahl, translated by Daniela Rivero Mendoza, and published by the UF/IFAS Food Science and Human Nutrition Department. https://edis.ifas.ufl.edu/fs396 …”
Get full text

Occurrence of 1,4-dioxane in domestic wastewater and processed water: A case study of Thailand’s central plain by Rattanit Mantiya, Kusanthia Ladawan, Sethbhakdi Pavin, Pornwongthong Peerapong

“…1,4-Dioxane is an emerging water contaminant and probable human carcinogen. Its use in various applications and improper waste management can lead to water contamination. …”
Get full text

A Theoretical Model of Listeriosis Driven by Cross Contamination of Ready-to-Eat Food Products by C. W. Chukwu, F. Nyabadza

“…The results show that a reduction in the number of contaminated workers and removal of contaminated food products are essential in eliminating the disease in the human population and vice versa. The results have significant public health implications in the management and containment of any listeriosis disease outbreak.…”
Get full text

Extracellular Matrix Remodeling of the Umbilical Cord in Pre-eclampsia as a Risk Factor for Fetal Hypertension by Lech Romanowicz, Zofia Galewska

“…The human umbilical cord forms a connection between the placenta and the foetus. …”
Get full text

Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…The degradation of pre-miR-21 by TaRiboTACs significantly increases the radiotherapeutic susceptibility of cancer cells achieving efficient suppression of human lung adenocarcinoma A549 tumors in living mice.…”
Get full text

Water Quality of The Karedok Weir in Kecamatan Jatigede, Kabupaten Sumedang, West Java Province as a Source of Raw Water for Drinking Water by Aris Wulandani, Nurhasanah Nurhasanah, Sherly Ridhowati

“…Clean water is a funWeirental human need. This need for clean water can be met from groundwater and surface water. …”
Get full text

Evaluation of the Medical Assistance to Patients with Arterial Hypertension in Four Urban Áreas by Addys Díaz Piñera, Armando Rodríguez Salvá, Susana Balcindes Acosta, René García Roche, Nelsy Álvarez Mesa

“…The variables studied were related to the coverage and quality of human resources, the availability of material resources, the compliance of the main activities set for the process of assistance. …”
Get full text

New Geographical Regionalization of Russia by V. A. Gorbanyov

“…For each region area, population size and density, level of urbanization, natural, mechanical and overall population growth, GDP per capita, the structure of employment, Human Development Index were counted, and the appropriate analysis were made.…”
Get full text

The GbbZIP41 transcription factor participates in terpene trilactones biosynthesis in Ginkgo biloba L. by Nuo Wang, Yi Tu, Sirui Zeng, Jiabao Ye, Weiwei Zhang, Feng Xu, Yongling Liao

“…Terpene trilactones (TTLs) are important secondary metabolites in ginkgo tree (Ginkgo biloba), which play a crucial role in the treatment of human cardiovascular disease and prevention of thrombosis, and have been widely used in food, medicine and health products. …”
Get full text

Land Acquisition for the Eviction of Uncertified Residents Houses for the Widening of Manyar Highway by Maulidya Diegha Widyasari, Hardian Iskandar

“…This research makes an important contribution to the formulation of more humane, equitable, and sustainable land acquisition policies.…”
Get full text

Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements by Beyza Arslandaş Dinçtürk, Arzu Şahin Mantı, Cemile Kedici Alp, Ayşenur Altuğ Yıldırım, Arzu Kaya Mumcu

“…This study evaluated the effect of resin cements and post-space irrigation solutions on the push-out bond strength of diabetic and non-diabetic dentin. A total of 160 human central teeth (80 diabetic, 80 non-diabetic) were prepared using X5 files and obturated with AH Plus sealer and X5 gutta-percha. …”
Get full text

A Laboratory Study of Plasma Charging Inside Lava Tubes on the Lunar Surface by S. Gopalakrishnan, X. Wang, M. Horányi

“…Our results provide insights into the plasma charging environment inside lunar lava tubes that may be used as natural habitats for future human exploration on the surface of the Moon.…”
Get full text