Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa by Stefanie Hornschuh, Janan Janine Dietrich, Celokuhle Tshabalala, Fatima Laher

“…Human immunodeficiency virus (HIV) management of adolescents and young adults (AYAs) is particularly pertinent to sub-Saharan Africa, where the pediatric HIV burden is marked. …”
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Global Distribution, Public Health and Clinical Impact of the Protozoan Pathogen Cryptosporidium by Lorenza Putignani, Donato Menichella

“…Cryptosporidium spp. are coccidians, oocysts-forming apicomplexan protozoa, which complete their life cycle both in humans and animals, through zoonotic and anthroponotic transmission, causing cryptosporidiosis. …”
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Cadmium Tolerance and Detoxification Mechanisms of <i>Lentinula edodes</i>: Physiology, Subcellular Distribution, and Chemical Forms by Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong

“…<i>Lentinula edodes</i> has a strong cadmium-enrichment ability, posing a potential threat to human health. However, the cadmium tolerance and detoxification mechanisms of <i>Lentinula edodes</i> are not understood. …”
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Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O6-Alkylguanine-DNA Alkyltransferase Activity by Maria Tintoré, Anna Aviñó, Federico M. Ruiz, Ramón Eritja, Carme Fàbrega

“…Human O6-alkylguanine-DNA alkyltransferase (hAGT) is a DNA repair protein that reverses the effects of alkylating agents by removing DNA adducts from the O6 position of guanine. …”
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Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options by Wenjing Huang, Luwen Zhu, Wenjing Song, Mei Zhang, Lili Teng, Minmin Wu

“…It will become more apparent how the MGBA affects human health and disease with continuing advancements in this emerging field of biomedical sciences.…”
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A Maternal Loss‐of‐Function Variant in KHDC3L Gene Causes a Range of Adverse Pregnancy Outcomes: A Case Report by Zahra Anvar, Farnoosh Jafarpour, Bahia Namavar Jahromi, Andrea Riccio, Mohammad Hossein Nasr‐Esfahani, Maria Vittoria Cubellis

“…This case report broadens the understanding of KHDC3L's pathogenic variants and phenotypic spectrum, consistent with its crucial role during human pre‐ and post‐implantation development.…”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Interrogation of temporal and signalling-specific gene expression in this atlas, evaluated against cell type-specific gene expression in human complex trait data highlights the WNT-inhibitor gene TMEM88 as a regulator of mesendodermal lineages influencing cardiovascular and anthropometric traits. …”
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Neutrophils Promote Larynx Squamous Cell Carcinoma Progression via Activating the IL-17/JAK/STAT3 Pathway by Tianyi Liu, Shimin Zong, Yang Jiang, Rui Zhao, Jie Wang, Qingquan Hua

“…Incidence of LSCC increases every year, posing a great threat to human health. The underlying mechanism needs further study. …”
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Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis by Tobias Bomholt, Anders Krarup-Hansen, Martin Egfjord, Søren Schwartz Sørensen, Niels Junker

“…Kaposi Sarcoma (KS) is driven by human herpes virus 8 causing vascular proliferation which is induced by loss of immune function most often due to HIV or immunosuppressants. …”
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THE ROLE OF TEENAGEERS’ LIFE EXPERIENCE ACTUALIZATION IN THE FRAMEWORK OF THE SAFE SOCIAL ENVIRONMENT FORMATION by O. A. Selivanov

“…The author regards actualization of teenagers’ life experience as a promising direction for exploring the opportunities for creating the safe social environment.The individual socio-psychological functioning is delineated as a multilevel correlation of internal and external human resources used for resolving difficult situations. …”
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The Role of Higher Education in Reproduction of Social Inequality in the Labor Market of Kazakhstan by M. K. Shnarbekova

“…The author analyzes how the modern education system contributes to the formation of socio-economically determined choice of higher education, where the latter includes a decision on continue studying, choosing a university and specialty.The functioning of the higher education system is analyzed in the context of the interconnections of education, the labor market and family resources, which reflect the movement of human capital and current trends in social mobility in Central Asia, as exemplified by Kazakhstan.The article presents data from a study conducted among young professionals aged 21 to 29 years with a different level of education. …”
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Murine Typhus: An Important Consideration for the Nonspecific Febrile Illness by Gurjot Basra, Megan A. Berman, Lucas S. Blanton

“…Exposure to reservoir hosts and the flea vector place humans at risk for this disease. Clinician recognition of this entity is required for diagnosis and effective therapy.…”
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3D-QSAR and Docking Studies of a Series of β-Carboline Derivatives as Antitumor Agents of PLK1 by Jahan B. Ghasemi, Valentin Davoudian

“…An alignment-free, three dimensional quantitative structure-activity relationship (3D-QSAR) analysis has been performed on a series of β-carboline derivatives as potent antitumor agents toward HepG2 human tumor cell lines. A highly descriptive and predictive 3D-QSAR model was obtained through the calculation of alignment-independent descriptors (GRIND descriptors) using ALMOND software. …”
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Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense by Fanrui Kong, Zixuan Wang, Chuchu Zhang, Yihua Xiao, Muhammad Abdul Rehman Saeed, Weini Li, Akira Goto, Qingshuang Cai, Shanming Ji

“…Taken together, our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense, providing potential insights into therapeutic strategies for combating bacterial infections in humans.…”
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Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle by H. Stigter, T. Krap, W. L. J. M. Duijst

“…<b>Background/Objectives:</b> The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. …”
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Seasonality and the effectiveness of mass vaccination by Dennis L. Chao, Dobromir T. Dimitrov

“…., an annual rainy season) or human behavior (e.g., school calendars or seasonal migration).If a pathogen is only transmissible for a limited period of time each year,then seasonal outbreaks could infect fewer individuals than expected given the pathogen's in-season transmissibility.Influenza, with its short serial interval and long season,probably spreads throughout a population until a substantial fraction of susceptible individuals are infected.Dengue, with a long serial interval and shorter season,may be constrained by its short transmission season rather than the depletion of susceptibles.Using mathematical modeling, we show that mass vaccination is most efficient,in terms of infections prevented per vaccine administered,at high levels of coverage for pathogens that have relatively long epidemicseasons, like influenza, and at low levels of coverage for pathogens with short epidemic seasons, like dengue.Therefore, the length of a pathogen's epidemic season may need to beconsidered when evaluating the costs and benefits of vaccination programs.…”
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Histological Evaluation of Internal Dental Resorption: An Analysis of a Cohort of 50 Cases by Tania Puentes-Morelos, Víctor Simancas-Escorcia, Arnulfo Tarón-Dunoyer, Carlos M. Ardila, Antonio Díaz-Caballero

“…A descriptive study involved the examination of 50 human teeth extracted due to an unfavorable prognosis for retention in the oral cavity. …”
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Development Assessment of the Coal Industry of China Based on the Minimum Deviation Comprehensive Weight Evaluation Model by Shihua Ren, Dezhi Zheng, Yang Qu, Rongjun Qin, Xiaomiao Jiao, Jinyan Bai

“…And, coal consumption is the measurement index of demand pull and selecting resources, capital, technology, human resources, and the energy system form the measurement index of factor drive. …”
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A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders by Nur Faten Hafizah Rosli, Noor Shafina Mohd Nor, Rose Adzrianee Adnan, Siti Hamimah Sheikh Abdul Kadir

“…In the past few decades, the human skin has been identified as an important peripheral endocrine organ that is the main site for the synthesis of vitamin D through exposure to sunlight. …”
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Immunosenescence of Polymorphonuclear Neutrophils by Inga Wessels, Judith Jansen, Lothar Rink, Peter Uciechowski

“…Furthermore, there are numerous discrepancies between in vivo and in vitro results, as well as between results for murine and human PMN. Most of the reported functional changes can be explained by defective signaling pathways, but further research is required to get a detailed insight into the underlying molecular mechanisms. …”
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