Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation by Marcelo Larami Santoro, Ana Teresa Azevedo Sachetto, Jaqueline Gomes Rosa, Ricardo José Soares Torquato, Débora Andrade-Silva, Dilza Trevisan-Silva, Cynthia Zaccanini de Albuquerque, Solange M. T. Serrano, Vânia Gomes de Moura Mattaraia, Aparecida Sadae Tanaka, Maria Elisa Peichoto

“…Abstract Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for inducing thrombocytopenia in vivo. …”
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Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences by Shelly Sehgal, Sanjana Kaul, M. K. Dhar

“…The amplification promoting sequences were chosen from the Saccharomyces cerevisiae ARS, 5S rRNA regions of Plantago ovata and P. lagopus, proposed sites of replication pausing at Ste20 gene locus of S. cerevisiae, and the bend DNA sequences within fragile site FRA11A in humans. The gene amplification assays showed that plasmid bearing APS from yeast and human beings led to enhanced protein concentration as compared to the wild type. …”
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STREAMING MICROSCOPIC IMAGE DATA TO THE CLOUD STORAGE FOR DETECTION OF ACUTE LYMPHOBLASTIC LEUKEMIA USING CNN by P. Kravchenko, I. Burlachenko

“…However, the problem that remains to this day is that the diagnosis of the disease based on microscopic images of a human blood smear are manual. This method of diagnosis is prone to errors due to many factors, due to inattention, absence of a specialist in the locality, etc. …”
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Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence by ZHENG Qingyong, LI Tengfei, XU Jianguo, ZHOU Yongjia, MA Zhichao, WANG Na, LI Molan, YANG Wenjing, WU Peirun, WANG Haidong, TIAN Jinhui

“…Animal models have played an irreplaceable role in simulating human diseases. However, the integration of evidence from animal experiments has faced numerous challenges, including insufficient emphasis, significant heterogeneity in study designs, high publication bias, and discrepancies with clinical research practices. …”
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Comparison of New Tau PET-Tracer Candidates With [F]T808 and [F]T807 by Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD

“…No specific binding of [ 18 F]T808 was found in transgenic mice expressing mutant human P301L tau. In semiquantitative autoradiography studies on human Alzheimer disease slices, we observed more than 50% tau selective blocking of [ 18 F]T808 in the presence of 1 µmol/L of the novel ligands. …”
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Heterogeneous Photo-Fenton-like Degradation of Oxytetracycline Containing Wastewater by Gülin Ersöz, Ceren Orak

“…It can be absorbed to a limited extent by both humans and animals, so it can be detected at various levels in different water sources. …”
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Becoming a Climate Change Educator: First-grade Pupils’ Action Research by Sandra Kairė, Jovita Vaivadaitė, Augustina Kundrotaitė

“…The development of a personal relationship with climate change brings to the forefront the teacher‘s awareness of the need for climate change education at school to reduce the destructive activities of human beings in relation to the planet and mitigate the effects of human-induced climate change. …”
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Super-utilisateurs ou super-spécialistes ? Cartographie des catalyseurs de la transformation numérique en agence d’architecture by Aurélie de Boissieu

“…Detailed knowledge of these phenomena is crucial in order for architects and future architects to be actors and not victims of these digital transformations.Although the transformation of a practice is due to multiple factors, we suggest focusing on just one of them; that is, the internal organization and, more particularly, the human agents of digital transformation. In order to establish a cartography of the human agents of transformation in architectural studios, we thus question the catalytic roles that they play.The research is based on qualitative data from interviews and participant observation. …”
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Satellite-Based Forest Stand Detection Using Artificial Intelligence by Patrik Kovacovic, Rastislav Pirnik, Julia Kafkova, Mario Michalik, Alzbeta Kanalikova, Pavol Kuchar

“…Forests are vital for human health and well-being and hold significant ecological and economic value for humanity. …”
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Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

“…To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is crucial for the sequence-specific CCA polymerization. In the human enzyme, alterations within these regions have been shown to lead to the manifestation of disease. …”
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Hydrogeochemical characteristics and environmental significance of travertine landscape in Muji area by Rui AN, Miao SUN, Yiwei ZHANG, Bin LI, Wenpeng LI, Kun LIU

“…Among these, manganese, strontium, and cobalt were identified as potential non-carcinogenic health risks to humans, and arsenic was found to pose carcinogenic risks. …”
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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…In human patients with autoimmune, viral, and bacterial diseases, the generation of antibodies (Abs) to foreign antigens and/or autoantibodies to self-antigens usually occurs. …”
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Using deep learning model integration to build a smart railway traffic safety monitoring system by Chin-Chieh Chang, Kai-Hsiang Huang, Tsz-Kin Lau, Chung-Fah Huang, Chun-Hsiung Wang

“…Then, the YOLO v3 model was applied to detect intrusions of railway, especially humans’ intrusion. The above object detection model achieved an Overall accuracy (OA) of over 90% for different classes, and an OA of 95.68% for human detection. …”
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Fully 3D Printed Miniaturized Electrochemical Platform With Plug-and-Play Graphitized Electrodes: Exhaustively Validated for Dopamine Sensing by K S Jaya Lakshmi, Ramya K, Khairunnisa Amreen, Sanket Goel

“…The developed device is finally tested for real-time analysis on human blood and serum samples.…”
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Explanation of Water Indices and Criteria in the Urban Landscape in Order to Improve the Quality of Urban Environments by Zeynab khaleghi, Farah Habib, Hossein Zabihi

“…Such a stimulus has led human beings to recognize different aspects of water, including sensory and perceptual, visual, semantic, functional, physical-aesthetic, environmental, psychological, social, and temporal and this knowledge has provided the backdrop for a variety of water-based designs in the urban landscape. …”
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THE NEW WORLD INFORMATION AND COMMUNICATION ORDER DEBATE AND THE DEVELOPMENT OF INFORMATION AND COMMUNICATION TECHNOLOGY IN NIGERIA by BECKY ADE ALIEGBA

“… While the New World Information and Communication Order (NWICO) debate underlines the centrality of information and communication development to societal transformation in the twenty-first century, it has unarguably led to explosion in human communication in ways previously thought impossible. …”
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Design of a Water Quality Monitoring Network on the Zimkan River in Kermanshah by Iraj Jabbari

“…According to vulnerability of reaches, nine monitoring locations were suggested at three situations: the confluence of tributaries which are subjected to intense human interference; The effect of two main branches of Zimkan in where they are close together at the end of catchment; and before and after the entrance of the main pollutant that it is possible to measure amount of their pollution. …”
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Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer by Jesenia M. Perez, Jolene M. Duda, Joohyun Ryu, Mihir Shetty, Subina Mehta, Pratik D. Jagtap, Andrew C. Nelson, Boris Winterhoff, Timothy J. Griffin, Timothy K. Starr, Stefani N. Thomas

“…We demonstrate that the utilization of patient-specific databases guided by transcriptional profiles increases the depth of human protein identification in PDX models. Our data show that human proteomes of serially passaged PDXs differ significantly from their patient-derived tumor of origin. …”
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Apocalyptic Propaganda: How the U.S. Government Manufactured Consent on The War on Terror by Carin Blom, Tomas Lindgren

“…War and propaganda have been linked together for a long time because of a natural human inhibition against killing other humans. To get citizens to give their consent to go to war and kill, the leader(s) need to influence them. …”
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Comprehensive evaluation and attribution analysis of baseflow variation in a typical karst basin, Southwest China by Chongxun Mo, Changhao Jiang, Shiting Long, Weiyan Cen

“…Climate changes were the main cause of baseflow variation in impact period T3 (1993–1998), while human activities were the main cause of baseflow variation in impact periods T2 and T4 (1979–1992, 1999–2019). …”
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