Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy by Kahori Seto, Junichi Shoda, Tomohisa Horibe, Eiji Warabi, Masayuki Kohno, Toru Yanagawa, Hiroki Bukawa, Yasuni Nakanuma, Koji Kawakami

“…It is known that the interleukin-4 receptor α (IL-4Rα) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4Rα-lytic hybrid peptide composed of binding peptide to IL-4Rα and cell-lytic peptide and reported that the designed IL-4Rα-lytic hybrid peptide exhibited cytotoxic and antitumor activity both in vitro and in vivo against the human pancreatic cancer cells expressing IL-4Rα. …”
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Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars by R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda

“…With regard to economic and ethical criteria and to the anatomical and physiological similarity to humans, the pig is the best source of xenografts. …”
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CONCORDANCE OF TECHNOGENESIS WITH ECODEVELOPMENT by S. M. Sukhorukova, A. M. Pogorelyi, S. G. Vysotskiy

“…In this regard technological equipment it is more preferable to the businessman than the human, because the equipment does not care how much the natural environment degrades after its use. …”
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Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus by Henry Liu, Adelie Y.S. Tan, Nasim F. Mehrabi, Clinton P. Turner, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains, Amy M. Smith

“…Our study presents novel and potentially modifiable glial changes in the AD human brain that are critical to our understanding of disease pathogenesis.…”
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An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches by Josefin A. Engelhardt, Merle M. Plassmann, Jana M. Weiss

“…Human serum from 60 blood donors in Stockholm, Sweden, was analyzed. …”
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Assessment and zoning of the geomorphological quality of Vardavard river in Tehran by negar mirzaii, ali ahmadabadi, Seyed morovat eftekhari, elaheh lofti

“…Rivers are always vital arteries of the earth and naturally, they have a gradual and continuous development process which has undergone fundamental changes after the expansion of human settlements and urban development and they have lost some of their natural functions. …”
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Study on the Influence of LED Spectrum on the Visual and Nonvisual Effects in the Interior Zone of Tunnels by Li-Li Dong, Peng Liu, Qi Lou, Wen-Hai Xu

“…This study evaluated the biological effects of spectrum on human visual and nonvisual under mesopic vision category. …”
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Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain by Andrew Silberfeld, James M. Roe, Jacob Ellegood, Jason P. Lerch, Lily Qiu, Yongsoo Kim, Jong Gwan Lee, William D. Hopkins, Joanes Grandjean, Yangming Ou, Olivier Pourquié

“…Left-right asymmetry of the human brain is widespread through its anatomy and function. …”
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A Model System for Concurrent Detection of Antigen and Antibody Based on Immunological Fluorescent Method by Yuan-Cheng Cao

“…This paper describes a combined antigen/antibody immunoassay implemented in a 96-well plate using fluorescent spectroscopic method. First, goat anti-human IgG was used to capture human IgG (model antigen); goat anti-human IgG (Cy3 or FITC) was used to detect the model antigen; a saturating level of model antigen was then added followed by unlabelled goat anti-human IgG (model antibody); finally, Cy3 labelled rabbit anti-goat IgG was used to detect the model antibody. …”
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Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…It also showed significantly improved persistence and comparable tumor control in a microphysiological human in vitro model and a xenograft model of human glioblastoma, but also demonstrated increased off-target recognition of IL-13Rα1.Conclusion Taken together, this work demonstrates the utility of extending CARPOOL to diseases beyond hematological malignancies and represents the largest exploration of signaling combinations in human primary cells to date.…”
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Medieval Overexploitation of Peat Triggered Large-Scale Drowning and Permanent Land Loss in Coastal North Frisia (Wadden Sea Region, Germany) by Hanna Hadler, Antonia Reiß, Timo Willershäuser, Dennis Wilken, Ruth Blankenfeldt, Bente Majchczack, Stefanie Klooß, Ulf Ickerodt, Andreas Vött

“…Along the southern North Sea coast from the Netherlands to Denmark, human cultivation efforts have created a unique cultural landscape. …”
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Czym jest edukacja biologiczna w wychowaniu człowieka? by Ilona Żeber-Dzikowska

“…No one should forget that human education starts already in the period of childhood. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…The liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. …”
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Epidemiology and transmission patterns of Cryptosporidium spp., and Giardia duodenalis within a One Health framework in rural areas of Eastern Algeria by Sadiya Maxamhud, Nassiba Reghaissia, AbdElKarim Laatamna, Eleni Gentekaki, Anastasios D. Tsaousis

“…Several Cryptosporidium species, including C. bovis, C. ryanae, C. andersoni and C. parvum, were identified in human, animal and environmental samples. The zoonotic C. parvum subtype IIaA17G2R1 was detected in human, animal and soil samples. …”
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PARADIGM FOR CONTEMPORARY SYMBOLIC REALITY by Elena Korableva

“…Adequate entry into the modern social context requires analysis of the basic concepts of symbolic reality of human existence, and its contemporary sound. The dialectical materialist methodology allows us to investigate human immersion in contradictive meanings of the era, the skills of interaction with the increased flow of information, the ability to determine information needs and use this information right way as well as the ability to analyze this information. …”
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Rosmini's metaphysical evidence for the existence of God by N. P. Swartz

“…The perfect Being (God) in his totality and completeness is thus not subject to human knowledge or existence. Human reason can only know what is revealed to it through nature. …”
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Re-assembling the Victorians: Steampunk, Cyborgs, and the Ethics of Industry by Helena Esser

“…If Victorian discourse established a binary opposition between the organic and the mechanic in order to negotiate human identity in the rapidly transforming age of Industrialisation, steampunk re-envisions and re-assembles this binary in order to challenge its validity in the digital age. …”
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Divine Evolution: Empedocles’ Anthropology by A. V. Halapsis

“…Cod can become a human (for example, for a deed unworthy of a deity), and a human can become God. …”
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Evaluation of the Most Current and Effective Methods in the Analysis of Chlorinated Dioxins in Ground Beef by Ebere C. Anyanwu, Mohamed H. El-Saeid, Akpan I. Akpan, Mahmoud A. Saled

“…They are lipophilic and can easily biomagnify in the food chain, hence posing a serious threat to human health. The daily consumption of low-level contaminated food, mainly of animal origin, leads to the accumulation of dioxins in the human body. …”
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Los Objetivos del Buen Vivir. Una propuesta alternativa a los Objetivos de Desarrollo Sostenible by Antonio Luis HIDALGO-CAPITÁN, Santiago GARCÍA-ÁLVAREZ, Ana Patricia CUBILLO-GUEVARA, Ana Patricia CUBILLO-GUEVARA, Nancy MEDINA-CARRANCO

“…We understand this concept as that way of life that allows human beings to coexist in harmony with other beings of nature, with other human beings and with ourselves. …”
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