The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders by Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey

“…In this review, we highlight the critical role of the GlyR α2 subunit revealed by knockout mice and our current understanding of GlyR α2 pathomechanisms in human NDDs. Finally, we will consider the current gaps in our knowledge, which include: (i) Limited functional validation for GlyR α2 missense variants associated with human NDDs; (ii) The lack of gain-of-function GlyR α2 mouse models; (iii) Our limited knowledge of GlyR α2 interacting proteins. …”
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Measurement of Quality of Life III. From the IQOL Theory to the Global, Generic SEQOL Questionnaire by Soren Ventegodt, Joav Merrick, Niels Jorgen Andersen

“…Unfortunately, the depth of human existence is to some extent lost in QOL5.We continue to aim towards greater simplicity, precision, and depth in the questions in order to explore the depths of human existence. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…The causal organism is Fasciolopsis buski, a giant intestinal fluke that infects humans and causes diarrhoea, fever, ascites, and intestinal blockage. …”
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IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta. by Marjo K Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja S Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

“…The involvement of the three IP3R genes (ITPR1, ITPR2 and ITPR3) in inherited human diseases has started to shed light on the essential roles of each receptor in different human tissues and cell types. …”
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Endothelial Glycocalyx Shedding Occurs during Ex Vivo Lung Perfusion: A Pilot Study by Timothy M. Sladden, Stephanie Yerkovich, Douglas Wall, Maxine Tan, William Hunt, Jonathan Hill, Ian Smith, Peter Hopkins, Daniel C. Chambers

“…Endothelial glycocalyx products accumulate during both porcine and human EVLP, and this accumulation parallels an accumulation of matrix-degrading enzyme activity. …”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…Porcine has spurred an increased interest in biomedical research models and xenotransplantation, owing to most of its organs share similarities in physiology, cellular composition and size to humans. Therefore, characterization of stem/progenitor cells in porcine organs or tissues may provide a novel avenue to better understand the biology and function of stem cells in humans. …”
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FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…HSALR and TfR1 hu/mu ;DMSXL Tg/Tg mice were used as models of myotonic dystrophy, the latter expresses human TfR1 and a human DMPK RNA with >1,000 CUG repeats. …”
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Biodiversity Change in Cultural Landscapes—The Rural Hotspot Hypothesis by Carsten Neumann, Robert Behling, Gabriele Weiss

“…ABSTRACT A dramatic decrease of biodiversity is currently questioning human‐environment interactions that have shaped ecosystems over thousands of years. …”
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Epidemiological and genomic analysis of Acinetobacter baumannii strains from retailed raw meat by Leila Hamze, Raquel Garcia-Fierro, Antoine Drapeau, Pauline François, Andrea Endimiani, Jean-Yves Madec, Marisa Haenni, Vincent Perreten, Agnese Lupo

“…Acinetobacter baumannii causes hospital-acquired infections in human patients with compromised immune system. Strains associated to nosocomial infections are often resistant to carbapenems and belong to few international clones (IC1-11). …”
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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

“…Similar macrophages could be differentiated from human CD14+ monocytes in the presence of interleukin 34 plus interleukin 4, and a therapeutic effect was observed using a humanized mouse model. …”
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Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner by Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris

“…We demonstrate that CL inhibits the lipopolysaccharide- (LPS-) induced secretion of cytotoxins and expression of glial fibrillary acidic protein (GFAP) by human U118 MG astrocytic cells. CL alone upregulates the phagocytic activity of human astrocytic cells and primary murine astrocytes. …”
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Dynamin-1 is a potential mediator in cancer-related cognitive impairment by Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan

“…Through a stepwise approach, this study investigated the role of DNM1 in CRCI pathogenesis, incorporating both human data and animal models. The human study recruited newly diagnosed, chemotherapy-naïve adolescent and young adult cancer and non-cancer controls to complete a cognitive instrument (FACT-Cog) and blood draws for up to three time points. …”
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Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations. by Chenxing Liu, Myoung Keun Lee, Sahin Naqvi, Hanne Hoskens, Dongjing Liu, Julie D White, Karlijne Indencleef, Harold Matthews, Ryan J Eller, Jiarui Li, Jaaved Mohammed, Tomek Swigut, Stephen Richmond, Mange Manyama, Benedikt Hallgrímsson, Richard A Spritz, Eleanor Feingold, Mary L Marazita, Joanna Wysocka, Susan Walsh, Mark D Shriver, Peter Claes, Seth M Weinberg, John R Shaffer

“…Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. …”
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Trends in the use of information and communication technologies in the teaching of foreign languages and translator training by N. Kovalchuk

“…The analysis showed that there is a considerable lack of sufficient research in the first area, as well as contradictory results in the remaining three (discrepancies in the evaluation of the translation efficiency of different MT systems and of MT compared to humans; unavailability of an effective and economical methodology for the evaluation of texts produced with the use of MT; the absence of a rational methodology for the application of post-editing at different stages of training and under different conditions). …”
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Information: on the question as for the meaningful evolution of the term by O. S. Bakumov, M. I. Marchuk, T. I. Gudz, О. О. Venglinskyi

“…It is concluded that it is impossible to determine the status of human thought as a form of information in today's conditions, as this may be the first step towards violation of immunity of the personal "inner world" of a human.…”
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Evaluation of Leea rubra Leaf Extract for Oxidative Damage Protection and Antitumor and Antimicrobial Potential by Nibedita Das, Sanowar Hossain, Jaytirmoy Barmon, Shahnaj Parvin, Mahadi Hasan, Masuma Akter, Ekramul Islam

“…So, the present study was designed to evaluate the protective role of the extract against oxidative damage to DNA and human erythrocytes as well as antitumor and antibacterial activities against some resistant bacteria. …”
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Studies on humoral immunity in dogs after use of rabies inactivated vaccines formulated with Montanide ISA 70 VG and GEL 01 adjuvants by A. N. Balashov, M. I. Doronin, A. V. Borisov, D. A. Lozovoy, D. V. Mikhalishin, V. A. Starikov

“…As an acute endemic infection, it poses a considerable danger to both animals and humans. The leading role in the transmission of rabies to humans belongs to diseased dogs; stray animals can be potential sources of rabies agent, which increases the risk of transmitting a deadly virus to humans. …”
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Understanding Recruiters’ Acceptance of Artificial Intelligence: Insights from the Technology Acceptance Model by Filomena Almeida, Ana Junça Silva, Sara L. Lopes, Isabel Braz

“…Specifically, the findings show the importance of ethical considerations and maintaining human involvement to ensure a balanced and effective integration of AI tools.…”
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Effect of Washing Bays on Water Quality of Rivers: A Case Study of River Rurigita Muko Sub-County Rubanda District Uganda. by Monday, Innocent

“…Water plays a significant role in maintaining human health and is a fundamental need for all living organisms. …”
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INDICATORS OF EFFICIENCY OF THE PILOTLESS AVIATION COMPLEX by A. S. Benkafo

“…The general principles of an estimation of efficiency of application of pilotless aviation complexes are considered at monitoring of a terrestrial surface in the conditions of presence of unauthenticity of the information on the basis of mathematical  modelling  with  the  account  of  hierarchical  construction  and  influence of  the  human  factor.  The substantiation of indicators of efficiency of information system and likelihood characteristics of an estimation of the information necessary for decision-making is spent.…”
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